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Photoresponsive cAMP signal transduction in cyanobacteria

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Abstract

The molecular mechanism of cAMP-mediated signal transduction from light reception to the physiological response via regulation of gene expression in cyanobacteria is described based on our recent works. Cyanobacteria are known as the organisms that acquired oxygen-evolving, higher plant type photosynthesis. We have found that the cellular cAMP level in the filamentous cyanobacteria Anabaena was oppositely regulated by red and far-red light, i.e., decreasing and increasing, respectively, suggesting that a phytochrome-like red/far-red photoreversible pigment regulates the activity of a certain adenylate cyclase. On the other hand, in the unicellular cyanobacterium Synechocystis cellular cAMP content was increased by blue light irradiation, which led to stimulation of cell motility. The cAMP signaling pathway is known to play an important role in the regulation of various biological activities by altering enzyme activities or controlling gene expression levels in both prokaryotes and eukaryotes. We have isolated genes for adenylate cyclases and cAMP receptor proteins and characterized their molecular properties. Disruption of these genes resulted in the loss of cell motility. It is concluded that the light signal was transmitted by cAMP signal cascade in cyanobacteria.

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  1. Masayuki Ohmori

    Present address: Center for System Biology and Ecology, Faculty of Science, Toho University, Hunabashi, 274, Japan

  2. Shinobu Okamoto

    Present address: Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011, Japan

Authors and Affiliations

  1. Department of Life Sciences (Biology), Graduate School of Arts and Sciences The University of Tokyo, Meguro, Tokyo, 153-8902, Japan

    Masayuki Ohmori & Shinobu Okamoto

  2. Department of Molecular Biology, Saitama University, Saitama, 338-8570, Japan

    Masayuki Ohmori

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Ohmori, M., Okamoto, S. Photoresponsive cAMP signal transduction in cyanobacteria. Photochem Photobiol Sci 3, 503–511 (2004). https://doi.org/10.1039/b401623h

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  • DOI: https://doi.org/10.1039/b401623h

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