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History of phototherapy in dermatology

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Abstract

Over many centuries, treatment with sunlight or “heliotherapy” was used in the treatment of skin diseases. More than 3500 years ago, ancient Egyptian and Indian healers used the ingestion of plant extracts or seeds in addition to sunlight for treating “leucoderma”. Modern phototherapy began with Nobel Prize winner Niels Finsen who developed a “chemical rays” lamp with which he treated patients with skin tuberculosis. However, it took several decades until phototherapy was introduced anew into the dermatological armamentarium. It was the development of photochemotherapy (PUVA) in 1974 that marked the beginning of a huge upsurge in photodermatology. The subsequent development of high intensity UV sources with defined spectra facilitated an optimized therapy for psoriasis and led to an expansion of indications for photo(chemo)therapy also in combination with topical and systemic agents. The introduction of extracorporeal photopheresis in 1987 for cutaneous T-cell lymphoma and of topical photodynamic therapy widely expanded the therapeutic possibilities in dermato-oncology.

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References

  1. M. A. Pathak, and T. B. Fitzpatrick, The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD, J. Photochem. Photobiol., B, 1992, 14, 3–22.

    Article  CAS  Google Scholar 

  2. A. H. Downes, and T. P. Blunt, Researches on the effect of light upon bacteria and other organisms, Proc. R. Soc. London, 1877, 26, 488–500.

    Google Scholar 

  3. T. A. Palm, The geographical distribution and aetiology of rickets. The Practitioner, October and November, 1890.

  4. N. R. Finsen, Om Lysets Indvirkninger paa Huden [On the effects of light on the skin], Hospitalstidende, 1893, 36, 721–728.

    Google Scholar 

  5. N. R. Finsen, Om Anvendelse i Medicinen af koncentrerede kemiske Lysstraaler. [On the application in medicine of concentrated chemical rays of light], Gyldendalske Boghandels Forlag, Copenhagen, 1896.

    Google Scholar 

  6. N. R. Finsen, and H. Forchhammer, Resultate der Lichtbehandlung bei unseren ersten 800 Fällen von Lupus vulgaris. [Results of light therapy in our first 800 cases of lupus vulgaris], Mitt. Fins. Med. Lichtinst., 1904, 5/6, 1–48.

    Google Scholar 

  7. R. Roelandts, A new light on Niels Finsen, a century after his nobel prize, Photodermatol., Photoimmunol. Photomed., 2005, 21, 115–117.

    Article  Google Scholar 

  8. W. H. Goeckerman, Treatment of psoriasis, Northwest Med., 1925, 24, 229–231.

    Google Scholar 

  9. J. T. Ingram, The approach to psoriasis, Br. Med. J., 1953, 12(2), 591–594.

    Article  Google Scholar 

  10. A. Wiskemann, Die neuere Entwicklung der Lichttherapie. [Recent developments in light therapy], Dermatol. Wochenschr., 1963, 20(147), 377–383.

    Google Scholar 

  11. I. R. Fahmy, H. Abu-Shady, A. A. Schönberg, Crystalline principle from Ammi majus L., Nature, 1947, 160(4066), 468.

    Article  CAS  Google Scholar 

  12. I. R. Fahmy, H. Abu-Shady, Ammi majus Linn: The isolation and properties of ammoidin, ammidin and majudin, and their effect in the treatment of leukoderma, Q. J. Pharm. Pharmacol., 1948, 21(4), 499–503.

    CAS  Google Scholar 

  13. A. M. El-Mofty, A preliminary clinical report on the treatment of leukoderma with Ammi majus Linn, J. Egypt. Med. Assoc., 1948, 31, 651–665.

    Google Scholar 

  14. B. Allyn, Studies on phototoxicity in man and laboratory animals. Paper presented at the Twenty-First Annual Meeting of the American Academy of Dermatology, Chicago, December 1962.

    Google Scholar 

  15. L. Oddoze, P. Témime, J. P. Marchand, and M. Benne, L‘association “meladinine” per os et rayons U.V. dans le traitement du psoriasis. [Combined oral meladinine and ultraviolet rays in the treatment of psoriasis], Bull. Soc. Fr. Dermatol. Syphiligr., 1967, 74(5), 609–610.

    CAS  Google Scholar 

  16. S. M. Mortazawi, Meladinine und UVA bei Vitiligo, Psoriasis, Parapsoriasis und Akne vulgaris. [Meladinine and UVA in vitiligo, psoriasis, parapsoriasis and acne vulgaris], Dermatol. Monatsschr., 1972, 158, 908–909.

    Google Scholar 

  17. J. A. Parrish, T. B. Fitzpatrick, L. Tanenbaum, and M. A. Pathak, Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light, N. Engl. J. Med., 1974, 291(23), 1207–1211.

    Article  CAS  Google Scholar 

  18. K. W. Wolff, T. B. Fitzpatrick, J. A. Parrish, F. Gschnait, B. Gilchrest, H. Hönigsmann, M. A. Pathak, and L. Tanenbaum, Photochemotherapy for psoriasis with orally administered methoxsalen, Arch. Dermatol., 1976, 112(7), 943–950.

    Article  CAS  Google Scholar 

  19. H. Hönigsmann, and K. Wolff, Results of therapy for psoriasis using retinoid and photochemotherapy (RePUVA), Pharmacol. Ther., 1989, 40(1), 67–73.

    Article  Google Scholar 

  20. T. Fischer, and J. Alsins, Treatment of psoriasis with trioxsalen baths and dysprosium lamps, Acta Derm. Venereol., 1976, 56(5), 383–390.

    CAS  Google Scholar 

  21. J. A. Parrish, and K. F. Jaenicke, Action spectrum for phototherapy of psoriasis, J. Invest. Dermatol., 1981, 76(5), 359–362.

    Article  CAS  Google Scholar 

  22. H. van Weelden, H. Baart de la Faille, E. Young, J. C. van der Leun, A new development in UVB phototherapy of psoriasis, Br. J. Dermatol., 1988, 119(1), 11–9.

    Article  Google Scholar 

  23. C. Green, J. Ferguson, T. Lakshmipathi, and B. E. Johnson, 311 nm UVB phototherapy–an effective treatment for psoriasis, Br. J. Dermatol., 1988, 119(6), 691–696.

    Article  CAS  Google Scholar 

  24. R. S. Stern, PUVA follow-up study. The risk of squamous cell and basal cell cancer associated with psoralen and ultraviolet A therapy: a 30-year prospective study, J. Am. Acad. Dermatol., 2012, 66(4), 553–562.

    Article  CAS  Google Scholar 

  25. R. M. Hearn, A. C. Kerr, K. F. Rahim, J. Ferguson, and R. S. Dawe, Incidence of skin cancers in 3867 patients treated with narrow-band ultraviolet B phototherapy, Br. J. Dermatol., 2008, 159(4), 931–935.

    Article  CAS  Google Scholar 

  26. J. Krutmann, W. Czech, T. Diepgen, R. Niedner, A. Kapp, E. Schöpf, High-dose UVA1 therapy in the treatment of patients with atopic dermatitis, J. Am. Acad. Dermatol., 1992, 26 2 Pt 1, 225–230.

    Article  CAS  Google Scholar 

  27. E. B. Kroft, N. J. Berkhof, P. C. van de Kerkhof, R. M. Gerritsen, E. M. de Jong, Ultraviolet A phototherapy for sclerotic skin diseases: a systematic review, J. Am. Acad. Dermatol., 2008, 59(6), 1017–1030.

    Article  Google Scholar 

  28. R. Edelson, C. Berger, and F. Gasparro, et al., Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results, N. Engl. J. Med., 1987, 316, 297–303.

    Article  CAS  Google Scholar 

  29. F. Trautinger, R. Knobler, and R. Willemze, et al., EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome, Eur. J. Cancer, 2006, 42, 1014–1030.

    Article  Google Scholar 

  30. H. T. Greinix, B. Volc-Platzer, and W. Rabitsch, et al., Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease, Blood, 1998, 92, 3098–3104.

    Article  CAS  Google Scholar 

  31. H. T. Greinix, R. M. Knobler, and N. Worel, et al., The effect of intensified extracorporeal photochemotherapy on long-term survival in patients with severe acute graft versus-host disease, Haematologica, 2006, 91, 405–408.

    Google Scholar 

  32. R. Dall‘Amico, and L. Murer, Extracorporeal photochemotherapy: a new therapeutic approach for allograft rejection, Transfus. Apheresis Sci., 2002, 26, 197–204.

    Article  Google Scholar 

  33. O. Raab, Über die Wirkung Fluorescierenden Stoffe auf Infusorien. [On the efffect of fluorescent substances on infusoria], Z. Biol., 1904, 39, 524–546.

    Google Scholar 

  34. H. von Tappeiner, and A. Jodlbauer, Über die Wirkung der photodynamischen (fluorescierenden) Stoffe auf Protozoen und Enzyme. [On the effect of photodynamic (fluorescent) substances on protozoa and enzymes], Dtsch. Arch. Klin. Med., 1904, 80, 427–487.

    Google Scholar 

  35. H. Jesionek, H. von Tappeiner, Zur Behandlung der Hautcarcinome mit fluoreszierenden Stoffen. [On the treatment of skin carcinomas with fluorescent substances], Dtsch. Arch. Klin. Med., 1905, 82, 223–226.

    Google Scholar 

  36. T. J. Dougherty, J. E. Kaufman, A. Goldfarb, K. R. Weishaupt, D. Boyle, and A. Mittleman, Photoradiation therapy for the treatment of malignant tumors, Cancer Res., 1978, 38(8), 2628–2635.

    CAS  Google Scholar 

  37. J. C. Kennedy, R. H. Pottier, and D. C. Pross, Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience, J. Photochem. Photobiol., B, 1990, 6, 143–148.

    Article  CAS  Google Scholar 

  38. P. Babilas, S. Karrer, A. Sidoroff, M. Landthaler, and R. M. Szeimies, Photodynamic therapy in dermatology—an update, Photodermatol., Photoimmunol. Photomed., 2005, 21(3), 142–149.

    Article  CAS  Google Scholar 

  39. K. C. Smith, Photobiology and photomedicine: the future is bright, J. Invest. Dermatol., 1981, 77(1), 2–7.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Medical University of Vienna, Vienna, Austria

    Herbert Hönigsmann

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Correspondence to Herbert Hönigsmann.

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This article is published as part of a themed issue on current topics in photodermatology.

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Hönigsmann, H. History of phototherapy in dermatology. Photochem Photobiol Sci 12, 16–21 (2013). https://doi.org/10.1039/c2pp25120e

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