Abstract
To document the remodeling of the asymmetric branching pattern of the coronary right ventricular branches (RVBs) in right ventricular hypertrophy (RVH), we computed an asymmetry ratio, S, for the diameters and lengths of all vessels, defined as the ratio of the daughter diameters and lengths, respectively. We have previously induced RVH in pigs by pulmonary stenosis for five weeks. At autopsy, silicone elastomer casts of the right coronary arteries were made and the morphometric data on the branching pattern and vascular geometry of the RVB were collected. Data on smaller vessels were obtained from histological specimens while data on larger vessels were obtained from vascular casts. The results show that the diameter asymmetry ratio was significantly decreased in RVH hearts. The asymmetry ratios of diameters and lengths were used to compute the asymmetry ratios for vascular resistance and flow of the various daughter vessels. It was found that the degree of asymmetry of the resistance and flow were decreased, which implies that the flow heterogeneity at a bifurcation is decreased in the RVH hearts. © 2000 Biomedical Engineering Society.
PAC00: 8719Uv, 8719Hh
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REFERENCES
1_ Bassingthwaighte, J., R. B. King, and S. A. Roger. Fractal nature of regional myocardial blood flow heterogeneity. Circ. Res.65:578-590, 1989.
2_ Costa, K. D., and A. D. McCulloch. Relationship between regional geometry and mechanics in a three-dimensional finite element model of the left ventricle. Adv. Bioeng.28:11-12, 1994.
3_ Delhass, T., T. Arts, F. W. Prinzen, and R. S. Reneman. Regional fiber stress-fiber strain area as an estimate of regional blood flow and oxygen demand in the canine heart. J. Physiol. (London)477:481-496, 1994.
4_ Einzig, S., J. J. Leonard, M. R. Tripp, R. V. Lucas, C. R. Swayze, and I. J. Fox. Changes in regional myocardial blood flow and variable development of hypertrophy after aortic banding in puppies. Cardiovasc. Res.15:711-723, 1981.
5_ Glass, G., P. D. Peckham, and J. R. Sanders. Consequences of failure to meet assumptions underlying the analysis of variance and covariance. Rev. Ed. Psychol.42:237-288, 1972.
6_ Giddens, D. P., C. K. Zarins, and S. Glagov. Response of arteries to near-wall fluid dynamic behavior. Appl. Mech. Rev.43:S98-S102, 1990.
7_ Hoffman, J. I. E.Heterogeneity of myocardial blood flow. Basic Res. Cardiol.90:103-111, 1995.
8_ Kamiya, A., and T. Togawa. Adaptive regulation of wall shear stress to flow change in the canine carotid artery. Am. J. Physiol.239:H14-H21, 1980.
9_ Kassab, G. S., and Y. C. Fung. Topology and dimensions of the pig coronary capillary network. Am. J. Physiol.267:H319-H325, 1994.
10_ Kassab, G. S., and Y. C. Fung. The pattern of coronary arteriolar bifurcations and the uniform shear hypothesis. Ann. Biomed. Eng.23:13-20, 1995.
11_ Kasaab, G. S., J. Berkley, and Y. C. Fung. Analysis of pig's coronary arterial blood flow with detailed anatomical data. Ann. Biomed. Eng.25:204-217, 1997.
12_ Kassab, G. S., D. Lin, and Y. C. Fung. Morphometry of the pig coronary venous system. Am. J. Physiol.267:H2100-H2113, 1994.
13_ Kassab, G. S., C. A. Rider, N. J. Tang, and Y. C. B. Fung. Morphometry of pig coronary arterial trees. Am. J. Physiol.265:H350-H365, 1993.
14_ Kassab, G. S., K. Imoto, F. C. White, C. A. Rider, Y. C. B. Fung, and C. M. Bloor. Coronary arterial tree remodeling in right ventricular hypertrophy. Am. J. Physiol.265:H366-H375, 1993.
15_ Lipowsky, H. H., S. Kovalcheck, and B. W. Zweifach. The distribution of blood rheological parameters in the microcirculation of cat mesentery. Circ. Res.43:738-749, 1978.
16_ Maxwell, S. E., and H. D. Delaney. Designing Experiments and Analyzing Data: A Model Comparison Perspective. Pacific Grove, CA: Brooks/Cole, 1990.
17_ Murray, C. D.The physiological principle of minimum work. I. The vascular system and the cost of blood volume. Proc. Natl. Acad. Sci. USA12:207-214, 1926.
18_ Prinzen, F. W., C. H. Augustijn, T. Arts, M. A. Allessie, and R. S. Reneman. Redistribution of myocardial fiber strain and blood flow by asynchronous activation. Am. J. Physiol.259:H300-H308, 1990.
19_ Thoma, R. Untersuchungen Uber die Histogenese und Histomechanik des Gefasssystems. Stuttgart: Enke, 1893.
20_ White, F. C., Y. Nakatani, L. Nimmo, and C. M. Bloor. Compensatory angiogenesis during progressive right ventricular hypertrophy. Am. J. Cardiovasc. Pathol.4:51-68, 1992.
21_ Yen, R. T., and Y. C. Fung. Inversion of the Fahraeus effect and effect of mainstream flow on capillary hematocrit. J. Appl. Physiol.: Respir., Environ. Exercise Physiol.42:578-586, 1978.
22_ Zamir, M.The role of shear forces in arterial branching. J. Gen. Biol.67:213-222, 1976.
23_ Zamir, M.Shear forces and blood vessel radii in the cardiovascular system. J. Gen. Physiol.69:449-461, 1977.
24_ Zarins, C. K., M. A. Zatina, D. P. Giddens, D. N. Ku, and S. Glagov. Shear stress regulation of artery lumen diameter in experimental atherogenesis. J. Vasc. Surg.5:413-420, 1987.
25_ Zhou, Y., G. S. Kassab, and S. Molloi. On the design of the coronary arterial tree: A generalization of Murray's law. Phys. Med. Biol.44:2929-2945, 1999.
26_ Zhuang, F. Y., Y. C. Fung, and R. T. Yen. Analysis of blood flow in cat's lung with detailed anatomical and elasticity data. J. Appl. Physiol.: Respir., Environ. Exercise Physiol.55:1341-1448, 1983.
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Kassab, G.S., Schatz, A., Imoto, K. et al. Remodeling of the Bifurcation Asymmetry of Right Coronary Ventricular Branches in Hypertrophy. Annals of Biomedical Engineering 28, 424–430 (2000). https://doi.org/10.1114/1.280
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DOI: https://doi.org/10.1114/1.280