Abstract
Continuous generation of hydrogen peroxide catalyzed by low concentrations of 1,1-dimethylhydrazine (heptyl), a rocket fuel component, in air-saturated water was shown by the method of enhanced chemiluminescence in a luminol-p–iodophenol–peroxidase system. The concentration dependence and the influence of heat and light on the formation of hydrogen peroxide in water under the influence of dimethylhydrazine at concentrations that are considerably lower than the maximum allowable concentrations were studied and the physico-chemical mechanism of this process was considered. It is supposed that dimethylhy-drazine at ultra-low concentrations is associated with air nanobubbles and represents a long-lived complex, which catalyzes the hydrogen peroxide formation under the influence of heat and light. We propose a new concept of the toxicity of dimethylhydrazine at very low concentrations due to impaired homeostasis of the formation of reactive oxygen species in aqueous solutions that enter humans and animals.
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Abbreviations
- UDMH:
-
unsymmetrical 1,1-dimethylhydrazine
- MAC:
-
maximum allowable concentration
References
Ya. T. Shatrov, V. I. Bruskov, G, B, Zavilgelsky, et al., New Aspects of Research on the Consequences of Using Heptyl in Rocket and Space Technology (Pelikan, Moscow, 2008) [in Russian].
L. E. Panin and A. Yu. Perova, Byull. Sib. Otd. Ross. Akad. Med. Nauk 1, 124 (2006).
A. D. Smolenkov, I. A. Rodin, and O. A. Shpigun, J. Anal. Chem. 67 (2), 98 (2012).
L. S. Yaguzhinskii, On the Toxicity of Heptyl (Inst. Inorg. Chem., Russ. Acad.Sci., Chernogolovka, 2014) [in Russian].
Yu. I. Misiichuk, G. F. Tereshchenko, G. P. Lebedev, et al., Ekol. Khim. 7, 42 (1998).
G. Ya. Evlashevskii, Byull. Sib. Med. 4, 21 (2002).
L. E. Panin, N. E. Kostina, and L. V. Shestopalova, Byull. Sib. Otd. Ross. Akad. Med. Nauk 4, 73 (2005).
L. E. Panin, E. Yu. Kleimenova, and G. S. Russkikh, Byull. Sib. Otd. Ross. Akad. Med. Nauk 4, 42 (2005).
A Reference Book on Toxicology and Hygienic Norms (MSCs) for Potentially Hazardous Substances, Ed. by V. S. Kushneva and R. B. Gorshkova (AT, Moscow, 1999) [in Russian].
E. E. Sotnikov and A. S. Moskovkin, J. Anal. Chem. 61, 139 (2006).
L. Carlsen, O. A. Kenesova, and S. E. Batyrbekova, Chemosphere 67, 1108 (2007).
G. Lunn and E. B. Sansone, Chemosphere 29, 1577 (1994).
G. L. Elizarova, L. G. Matvienko, O. P. Pestunova, et al., Kinet. Kataliz 39, 49 (1998).
O. P. Pestunova, G. L. Elizarova, Z. R. Ismagilov, et al., Catal. Today 75, 219 (2002).
E. C. Fleming, J. C. Pennington, B. G. Wachob, et al., J. Hazard Mater. 51, 151 (1996).
O. A. Makhotkina, E. V. Kuznetsova, and S. V. Preis, Appl. Catal. B: Environ. 6, 85 (2006).
E. Rotlerts, F. Younger, and S. Frankel, J. Biol. Chem. 191, 277 (1951).
Kh. Avakyan, Farmakol. Toksikol. 53, 70 (1990).
L. S. Yaguzhinskii, V. I. Bruskov, E. G. Smirnova, et al., Dvoinye Tekhnol. 3, 61 (2006).
I. N. Shtarkman, S. V. Gudkov, A. V. Chernikov, et al., Biokhimiya 73, 576 (2008).
S. V. Gudkov, V. I. Bruskov, M. E. Astashev, et al., J. Phys. Chem. B 115, 7693 (2011).
V. I. Bruskov, O. E. Karp, S. A. Garmash, et al., Free Radic. Res. 46, 1280 (2012).
V. I. Bruskov, N. R. Popova, V. E. Ivanov, et al., Biochem. Biophys. Res. Commun. 443, 957 (2014).
A. B. Gapeyev, N. A. Lukyanova, and S. V. Gudkov, Cent. Eur. J. Biol. 9, 915 (2014).
S. V. Gudkov, M. E. Astashev, V. I. Bruskov, et al., Entropy 16, 6166 (2014).
S. A. Garmash, V. S. Smirnova, O. E. Karp, et al., J. Environ. Radioact. 127, 163 (2014).
S. V. Gudkov, O. E. Karp, S. A. Garmash, et al., Biophysics (Moscow) 57, 1 (2012).
V. I. Bruskov, Zh. K. Masalimov, and A. V. Chernikov, Dokl. Biochem. Biophys. 384, 181 (2002).
V. I. Bruskov, L. V. Malakhova, Z. K. Masalimov, et al., Nucleic Acids Res. 30, 1354 (2002).
S. V. Gudkov, V. E. Ivanov, O. E. Karp, et al., Biophysics (Moscow) 59, 700 (2014).
V. I. Bruskov, S. V. Gudkov, V. S. Senin, et al., in AirSaturated Water: An Open Nonequilibrium, Active Medium, Ed. by A. B. Rubin, E. E. Fesenko, and G. R. Ivanitsky (Sinkhrobuk, Pushchino, 2013), pp. 8–10.
N. F. Bunkin, Zh. Eksp. Teor. Fiz. 101, 512 (1992).
N. F. Bunkin, N. V. Suyazov, A. V. Shkirin, et al., J. Chem. Phys. 130, 134308 (2009).
M. A. Margulis, Usp. Fiz. Nauk 130, 263 (2000).
V. H. Arakeri, Curr. Sci. 85, 911 (2003).
A. Tomasi, E. Albano, B. Botti, et al., Toxicol. Pathol. 15, 178 (1987).
Y. T. Didenko, W. B. McNamara, and K. S. Suslick, Nature 407, 877 (2000).
Y. T. Didenko and K. S. Suslick, Nature 418, 394 (2002).
I. A. Rodin, D. N. Moskvin, A. D. Smolenkov, and O. A. Shpigun, Russ. J. Phys. Chem. A 82 (6), 911 (2008).
A. K. Pikaev, Reaction Capacity of Primary Products of Water Radiolysis (Energoizdat, Moscow, 1982) [in Russian].
N. K. Zenkov, V. Z. Lankin, and E. B. Men’shchikova, Oxidative Stress: Biochemical and Pathophysiological Aspects (MAIK Nauka/Interperiodica, Moscow, 2001) [in Russian].
M. L. Circu and T. Y. Aw, Free Radic. Biol. Med. 48, 749 (2010).
G. B. Zavilgelsky, V. Y. Kotova, and I. V. Manukhov, Mutat. Res. 634, 172 (2007).
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Original Russian Text © V.I. Bruskov, L.S. Yaguzhinsky, Z.K. Masalimov, A.V. Chernikov, V.I. Emelyanenko, S.V. Gudkov, 2015, published in Biofizika, 2015, Vol. 60, No. 4, pp. 673–680.
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Bruskov, V.I., Yaguzhinsky, L.S., Masalimov, Z.K. et al. The continuous generation of hydrogen peroxide in water containing very low concentrations of unsymmetrical dimethylhydrazine. BIOPHYSICS 60, 553–558 (2015). https://doi.org/10.1134/S0006350915040065
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DOI: https://doi.org/10.1134/S0006350915040065