Skip to main content
SpringerLink
Log in

Changes in Cardiac, Respiratory and Motor Activity of Rat Fetuses Evoked by Injections of a Cholinesterase Inhibitor Physostigmine

  • Short Communications
  • Published:
Journal of Evolutionary Biochemistry and Physiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Stashina, E.V., Gavrilov, N.A., and Shabanov, P.D., Neurobehavioral effects of cholinergic drugs in the prenatal period, Rev. Clin. Pharmacol. Drug Ther., 2017, vol. 15 (3), pp. 5–21. doi: https://doi.org/10.17816/RCF1535-21

    Article  Google Scholar 

  2. Dwyer, J.B., McQuown, S.C., and Leslie, F.M., The dynamic effects of nicotine on the developing brain, Pharmacol Ther., 2009, vol. 122 (2), pp. 125–139.

    Article  CAS  Google Scholar 

  3. Steingart, R.A., Abu-Roumi, M., Newman, M.E., Silverman, W.F., Slotkin, T.A., and Yanai, J., Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts, Brain Res. Dev. Brain. Res., 2000, vol. 122 (2), pp. 125–131.

    Article  CAS  Google Scholar 

  4. Sizonov, V.A. and Dmitrieva, L.E., Heart rhythm disturbances caused by injection of a cholinesterase inhibitor physostigmine to rats during the early ontogeny, Bull. Exp. Biol. Med., 2018, vol. 165 (1), pp. 52–56.

    Article  Google Scholar 

  5. Letal’nye dozy vysokotoksichnykh veshchestv (Lethal doses of highly toxic substances), URL: http://chemister.ru/Toxicology/ld50.htm.

  6. Timofeeva, O.P. and Vdovichenko, N.D., A study of cardiac, respiratory and motor activities in rat fetuses, J. Evol. Biochem. Physiol., 2009, vol. 45 (6), pp. 559–566.

    Article  CAS  Google Scholar 

  7. Timofeeva, O.P., Vdovichenko, N.D., and Kuznetsov, S.V., Effect of a change in activity level of catecholaminergic systems on motor, respiratory and cardiac activities in rat embryos, J. Evol. Biochem. Physiol., 2012, vol. 48 (3), pp. 264–273.

    Google Scholar 

Download references

Funding

This work was implemented within the state assignment “Mechanisms of the formation of physiological functions during phylo- and ontogenesis as affected by endogenous and exogenous factors” (AAAA-A18-118012290373-7).

Author information

Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    N. D. Vdovichenko & O. P. Timofeeva

Authors
  1. N. D. Vdovichenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. P. Timofeeva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. D. Vdovichenko.

Ethics declarations

All applicable international, national and institutional principles of handling and using experimental animals for scientific purposes were observed.

This study did not involve human subjects as research objects.

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2019, Vol. 55, No. 4, pp. 295–298.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vdovichenko, N.D., Timofeeva, O.P. Changes in Cardiac, Respiratory and Motor Activity of Rat Fetuses Evoked by Injections of a Cholinesterase Inhibitor Physostigmine. J Evol Biochem Phys 55, 329–332 (2019). https://doi.org/10.1134/S0022093019040082

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0022093019040082

Search

Navigation