Abstract
In this study, a new Co(II)-containing coordination polymer with the chemical formula [Co(ox)(dimb)] (1, ox = oxalic acid, dimb = 1,4-di(1H-imidazol-1-yl)butane) is successfully prepared by the reaction of Co(NO3)2·6H2O, oxalic acid, and 1,4-di(1H-imidazol-1-yl)butane in a mixed solvent of DMF and water under the solvothermal conditions. As-prepared crystalline complex 1 is characterized by the elemental analysis and single crystal X-ray diffraction. Furthermore, the mechanical grinding method is used to produce nanostructured 1 with the average size distribution of around 326 nm. To detect the in vivo protective effect of nano 1 on CVB3-induced myocarditis, the histopathology evaluation is performed. To reveal the underlying relationship between the cell inflammatory response and the mechanism of the compound protective activity, the level of IL-1 and TNF-α in the myocardial tissue is measured by ELISA.
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Funding
This work was supported by grants from Research Projects of Institutions of Higher Learning in Inner Mongolia (NJZY17195) and Inner Mongolia Natural Science Foundation [2017MS(LH)0824].
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Text © The Author(s), 2020, published in Zhurnal Strukturnoi Khimii, 2020, Vol. 61, No. 3, pp. 518–523.
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A New Co(II)-Containing Coordination Polymer Constructed by the Mixed-Ligand Approach: Crystal Structure and Alleviation of CVB3-Induced Myocarditis by Inhibiting Inflammatory Cytokines Production
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Huo, W.X., Liu, X.T., Zhang, Z.F. et al. A New Co(II)-Containing Coordination Polymer Constructed by the Mixed-Ligand Approach: Crystal Structure and Alleviation of CVB3-Induced Myocarditis by Inhibiting Inflammatory Cytokines Production. J Struct Chem 61, 496–501 (2020). https://doi.org/10.1134/S0022476620030166
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DOI: https://doi.org/10.1134/S0022476620030166