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Composite materials for medical purposes based on polyvinylpyrrolidone modified with ketoprofen and silver nanoparticles

  • Physical Chemistry of Nanoclusters and Nanomaterials
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Abstract

A method for obtaining composite medical materials based on polyvinylpyrrolidone (PVP K15) modified with ketoprofen in a medium of supercritical carbon dioxide and with Ag nanoparticles prepared by metal vapor synthesis is developed. A system in which ketoprofen and Ag nanoparticles with an average size of ∼16 nm are uniformly distributed over the bulk of PVP is obtained. It is found that the yield of ketoprofen from the composite in the physiological solution is higher than that for an analogous system obtained by mechanical mixing of the components.

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Authors and Affiliations

  1. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, 119991, Russia

    L. N. Nikitin, A. Yu. Vasil’kov, A. V. Naumkin, V. L. Podshibikhin, S. S. Abramchuk, M. I. Buzin, A. A. Korlyukov & A. R. Khokhlov

  2. Faculty of Chemistry, Moscow State University, Moscow, 119992, Russia

    A. Yu. Vasil’kov

  3. Department of Material Science and Chemical Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Torino, Italy

    M. Banchero & L. Manna

Authors
  1. L. N. Nikitin
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  2. A. Yu. Vasil’kov
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  3. M. Banchero
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  4. L. Manna
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  5. A. V. Naumkin
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  6. V. L. Podshibikhin
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  7. S. S. Abramchuk
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  8. M. I. Buzin
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  9. A. A. Korlyukov
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  10. A. R. Khokhlov
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Corresponding author

Correspondence to L. N. Nikitin.

Additional information

Original Russian Text © L.N. Nikitin, A.Yu. Vasil’kov, M. Banchero, L. Manna, A.V. Naumkin, V.L. Podshibikhin, S.S. Abramchuk, M.I. Buzin, A.A. Korlyukov, A.R. Khokhlov, 2011, published in Zhurnal Fizicheskoi Khimii, 2011, Vol. 85, No. 7, pp. 1296–1301.

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Nikitin, L.N., Vasil’kov, A.Y., Banchero, M. et al. Composite materials for medical purposes based on polyvinylpyrrolidone modified with ketoprofen and silver nanoparticles. Russ. J. Phys. Chem. 85, 1190–1195 (2011). https://doi.org/10.1134/S0036024411070223

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  • DOI: https://doi.org/10.1134/S0036024411070223

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