Adsorption of ^99mTc on aluminum oxide

Abstract

Adsorption of ^99mTc under static and dynamic conditions on aluminum oxides subjected to various acid treatments at pH from 7.29 to 1.26 (until the reaction of the oxide with the acid fully ceased) was studied. In batch experiments, the maximal adsorption of ^99mT_c, more than 30% of the radionuclide activity, is attained with the oxide that absorbed 2 × 10⁻⁴ mol g⁻¹ acid. The “rate” of linear migration of ^99mT_c in a chromatographic column in the course of elution with a 0.9% NaCl solution under the conditions of limiting saturation of the oxide with the acid is 0.49–0.52 cm ml⁻¹. It is concluded that the observed deceleration of the ^99mT_c elution from the generator column is due to its “braking” by active sites of the oxide. Upon reduction of ^99mT_c with bivalent tin, its adsorption increases to 93.53%. The results obtained are of interest for the development of procedures for depositing ^99mT_c onto the surface of nanosized colloidal particles of aluminum oxide for their subsequent use in medical diagnostics.