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The synthesis and membrane protective properties of sulfanyl imines derived from neomenthane and isobornane thiols

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Abstract

Neomenthane and isobornane thiol-derived sulfanyl imines were prepared in yields of up to 85%. On the basis of the capacity of the sulfanyl imines obtained to inhibit the H2H2- and AAPH-induced erythrocyte hemolysis and impede the accumulation of secondary products of lipid peroxidation and hemoglobin oxidation, they were shown to display membrane protective and antioxidant properties.

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Abbreviations

AO:

antioxidants

NCS:

N-chlorosuccinimide

LPO:

lipid peroxidation

AAPH:

2,2-azobis(amidinopropane) dihydrochloride

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Authors and Affiliations

  1. Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, ul. Pervomayskaya 48, Syktyvkar, 167982, Russia

    E. S. Izmest’ev, D. V. Sudarikov, S. A. Rubtsova & A. V. Kutchin

  2. Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, ul. Kommunisticheskaya 28, Syktyvkar, 167982, Russia

    O. G. Shevchenko

  3. Syktyvkar State University, Oktyabrsky prosp. 55, Syktyvkar, 167001, Russia

    O. G. Shevchenko

Authors
  1. E. S. Izmest’ev
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  2. D. V. Sudarikov
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  3. O. G. Shevchenko
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  4. S. A. Rubtsova
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  5. A. V. Kutchin
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Corresponding author

Correspondence to D. V. Sudarikov.

Additional information

Original Russian Text © E.S. Izmest’ev, D.V. Sudarikov, O.G. Shevchenko, S.A. Rubtsova, A.V. Kutchin, 2015, published in Bioorganicheskaya Khimiya, 2015, Vol. 41, No. 1, pp. 90–96.

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Izmest’ev, E.S., Sudarikov, D.V., Shevchenko, O.G. et al. The synthesis and membrane protective properties of sulfanyl imines derived from neomenthane and isobornane thiols. Russ J Bioorg Chem 41, 77–82 (2015). https://doi.org/10.1134/S1068162014050070

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  • DOI: https://doi.org/10.1134/S1068162014050070

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