Abstract
Metabolomics, the youngest branch of “omics” sciences, intended for studying a comprehensive set of low molecular weight substances (metabolites) of various biological objects. Metabolite profiles represent a molecular phenotype of biological systems and reflect information encoded at the genome level and realized at the transcriptome and proteome levels. Analysis of the human blood metabolic profile is a universal and promising tool for clinical applications because it is a sensitive measure of both endogenous and exogenous (environmental) factors influencing the human body. In this review we discuss technical implementation of blood metabolic profiling methods and statistic analysis of metabolite profiles for effective diagnostics and risk assessments of diseases.
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Original Russian Text © O.P. Trifonova, P.G. Lokhov, A.I. Archakov, 2013, published in Biomeditsinskaya Khimiya.
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Trifonova, O.P., Lokhov, P.G. & Archakov, A.I. Metabolic profiling of human blood. Biochem. Moscow Suppl. Ser. B 7, 179–186 (2013). https://doi.org/10.1134/S1990750813030128
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DOI: https://doi.org/10.1134/S1990750813030128