Abstract
Drug delivery systems (DDS) can be designed to enrich the pharmacological and therapeutic properties of several drugs. Many of the initial obstacles that impeded the clinical applications of conventional DDS have been overcome with nanotechnology-based DDS, especially those formed by chitosan (CS). CS is a linear polysaccharide obtained by the deacetylation of chitin, which has potential properties such as biocompatibility, hydrophilicity, biodegradability, non-toxicity, high bioavailability, simplicity of modification, aqueous solubility, and excellent chemical resistance. Furthermore, CS can prepare several DDS as films, gels, nanoparticles, and microparticles to improve delivery of drugs, such as photosensitizers (PS). Thus, CS-based DDS are broadly investigated for photodynamic therapy (PDT) of cancer and fungal and bacterial diseases. In PDT, a PS is activated by light of a specific wavelength, which provokes selective damage to the target tissue and its surrounding vasculature, but most PS have low water solubility and cutaneous photosensitivity impairing the clinical use of PDT. Based on this, the application of nanotechnology using chitosan-based DDS in PDT may offer great possibilities in the treatment of diseases. Therefore, this review presents numerous applications of chitosan-based DDS in order to improve the PDT for cancer and fungal and bacterial diseases.
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Safari J, Zarnegar Z. Advanced drug delivery systems: nanotechnology of health design a review. J Saudi Chem Soc. 2014;18:85–99.
Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science. 2004;303:1818–22.
Ita K. Transdermal delivery of drugs with microneedles—potential and challenges. Pharmaceutics. 2015;7:90–105.
Suri S, Fenniri H, Singh B. Nanotechnology-based drug delivery systems. J Occup Med Toxicol. 2007;2:16–22.
Tiwari G, Tiwari R, SriwastawavB BL, Pandey S, Pandey P, Bannerjee SK. Drug delivery systems: an updated review. Int J Pharm Investig. 2012;2:2–11.
Gelperina S, Kisich K, Iseman MD, Heifets L. The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis. Am J Respir Crit Care Med. 2005;172:1487–90.
Bhagwat RR, Vaidhya IS. Novel drug delivery systems: an overview. Int J Pharm Sci Rev Res. 2013;4:970–82.
Calixto G, Duque C, Aida KL, Santos VR, Massunari L, Chorilli M. Development and characterization of p1025-loaded bioadhesive liquid-crystalline system for the prevention of Streptococcus mutans biofilms. Int J Nanomedicine. 2018;13:31–41.
Victorelli F, Calixto G, Ramos MAS, Bauab TM, Chorilli M. Metronidazole-loaded polyethyleneimine and chitosan-based liquid crystalline system for treatment of staphylococcal skin infections. J Biomed Nanotechnol. 2018;14:227–38.
Calixto G, Victorelli F, Dovigo L, Chorilli M. Polyethyleneimine and chitosan polymer-based mucoadhesive liquid crystalline systems intended for buccal drug delivery. AAPS PharmSciTech. 2018;19:820–36.
Frade ML, Annunzio SR, Calixto G, Victorelli F, Chorilli M, Fontana CR. Assessment of chitosan-based hydrogel and photodynamic inactivation against Propionibacterium acnes. Molecules. 2018;23:473.
Aida KL, Kreling PF, Caiaffa KS, Calixto G, Chorilli M, Spolidorio DMP, et al. Antimicrobial peptide-loaded liquid crystalline precursor bioadhesive system for the prevention of dental caries. Int J Nanomedicine. 2018;13:3081–91.
Rodero CF, Calixto G, Santos KC, Sato MR, Ramos MAS, Miro MS, et al. Curcumin-loaded liquid-crystalline systems for controlled drug release and improved treatment of vulvovaginal candidiasis. Mol Pharm. 2018;15:4491–504.
Ramos MAS, Calixto G, Toledo LG, Bonifacio BV, Santos LC, Chorilli M, et al. Liquid crystal precursor mucoadhesive system as a strategy to improve the prophylactic action of Syngonanthus nitens (Bong.) Ruhland against infection by Candida krusei. Int J Nanomedicine. 2015;10:7455–66.
Salmazi R, Calixto G, Bernegossi J, Ramos MAS, Bauab TM, Chorilli M. A curcumin-loaded liquid crystal precursor mucoadhesive system for the treatment of vaginal candidiasis. Int J Nanomedicine. 2015;10:4815–24.
Ramos MAS, Toledo LG, Calixto G, Bonifacio BV, Araujo MGF, Santos LC, et al. Syngonanthus nitens Bong. (Rhul.)-loaded nanostructured system for vulvovaginal candidiasis treatment. Int J Mol Sci. 2016;17:1.
Chytil P, Koziolová E, Etrych T, Ulbrich K. HPMA copolymer–drug conjugates with controlled tumor-specific drug release. Macromol Biosci. 2018;18:1–15.
Abdelaziz HM, Gaber M, Abd-Elwakil MM, Mabrouk MT, Elgohary MM, Kamel NM, et al. Inhalable particulate drug delivery systems for lung cancer therapy: nanoparticles, microparticles, nanocomposites and nanoaggregates. J Control Release. 2018;269:374–92.
Gupta S, Kesarla R, Omri A. Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems. ISRN Pharm. 2013;2013:1–16.
Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, et al. Drug delivery systems: advanced technologies potentially applicable in personalized treatments. EPMA J. 2010;1:164–209.
Peng H, Huang Q, Yue H, Li Y, Wu M, Liu W, et al. The antitumor effect of cisplatin-loaded thermosensitive chitosan hydrogel combined with radiotherapy on nasopharyngeal carcinoma. Int J Pharm. 2019;556:97–105.
Martínez-Martínez M, Rodríguez-Berna G, Bermejo M, Gonzalez-Alvarez I, Gonzalez-Alvarez M, Merino V. Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin. Eur J Pharm Biopharm. 2019. https://doi.org/10.1016/j.ejpb.2019.01.009.
Riaz Rajoka MS, Zhao L, Mehwish HM, Wu Y, Mahmood S. Chitosan and its derivatives: synthesis, biotechnological applications, and future challenges. Appl Microbiol Biotechnol. 2019. https://doi.org/10.1007/s00253-018-9550-z.
TiyaboonchaI W. Chitosan nanoparticles: a promising system for drug delivery. NUJS. 2013;11:51–66.
Ueno H, Mori T, Fujinaga T. Topical formulations and wound healing applications of chitosan. Adv Drug Deliv Rev. 2001;52:105–15.
Wang XH, Li DP, Wang WJ, Feng QL, Cui FZ, Xu YX, et al. Crosslinked collagen/chitosan matrix for artificial livers. Biomaterials. 2003;24:3213–20.
Tsai M, Chen R, Bai S, Chen W. The storage stability of chitosan/tripolyphosphate nanoparticles in a phosphate buffer. Carbohydr Polym. 2011;84:756–61.
Shimono N, Takatori T, Ueda M, Mori M, Higashi Y, Nakamura Y. Chitosan dispersed system for colon-specific drug delivery. Int J Pharm. 2002;245:45–54.
Agnihotri AS, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro-and nanoparticles in drug delivery. J Control Release. 2004;100:5–28.
Bernkop-Schnürch A, Dünnhaupt S. Chitosan-based drug delivery systems. Eur J Pharm Biopharm. 2012;81:463–9.
Dasha M, Chiellini F, Ottenbrite RM, Chiellini E. Chitosan—a versatile semi-synthetic polymer in biomedical applications. Prog Polym Sci. 2011;36:981–1014.
Schipper NG, Olsson S, Hoogstraate JA, deBoer AG, Vårum KM, Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement. Pharm Res. 1997;14:923–9.
Illum L, Jabbal-Gill I, Hinchcliffe M, Fisher AN, Davis SS. Chitosan as a novel nasal delivery system for vaccines. Adv Drug Deliv Rev. 2001;51:81–96.
Prabaharan M. Chitosan derivatives as promising materials for controlled drug delivery. J Biomater Appl. 2008;23:5–36.
Prabaharan M, Mano JF. Hydroxypropyl chitosan bearing β-cyclodextrin cavities: synthesis and slow release of its inclusion complex with a model hydrophobic drug. Macromol Biosci. 2005;5:965–73.
Nagpal K, Singh SK, Mishra DN. Chitosan nanoparticles: a promising system in novel drug delivery. Chem Pharm Bull. 2010;58:1423–30.
Kean T, Thanou M. Biodegradation, biodistribution and toxicity of chitosan. Adv Drug Deliv Rev. 2010;62:3–11.
Park JH, Saravanakumar G, Kim K, Kwon IC. Targeted delivery of low molecular drugs using chitosan and its derivatives. Adv Drug Deliv Rev. 2010;62:28–41.
Chatelet C, Damour O, Domard A. Influence of the degree of acetylation on some biological properties of chitosan films. Biomaterials. 2001;22:261–8.
Kumar MNVR. A review of chitin and chitosan applications. React Funct Polym. 2000;46:1–27.
Kumar MNVR, Muzzarelli RAA, Muzzarelli C, Sashiwa H, Domb AJ. Chitosan chemistry and pharmaceutical perspectives. Chem Rev. 2004;104:6017–84.
Koide SS. Chitin-chitosan: properties, benefits and risks. Nutr Res. 1998;18:1091–101.
Fontana CR, dos Santos Junior DS, Bosco JM, Spolidorio DM, Rosemary ACM. Evaluation of chitosan gel as antibiotic and photosensitizer delivery. Drug Deliv. 2008;15:417–22.
de Freitas LM, Soares CP, Fontana CR. Synergistic effect of photodynamic therapy and cisplatin: a novel approach for cervical cancer. J Photochem Photobiol B. 2014;140:365–73.
Fernandes SRG, Fernandes R, Sarmento B, Pereira PMR, Tomé JPC. Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy. Org Biomol Chem. 2019. https://doi.org/10.1039/c8ob02902d.
Ronqui MR, Coletti FA, Starck TM, de Freitas LM, Miranda ET, Fontana CR. Synergistic antimicrobial effect of photodynamic therapy and ciprofloxacin. J Photochem Photobiol B. 2016;158:122–9.
Sharma M, Dev SK, Kumar M, Shukla AK. Microspheres as suitable drug carrier in sustained release drug delivery: an overview. Asian J Pharm Pharmacol. 2018;4:102–8.
Kumar MNVR. Nano and microparticles as controlled drug delivery devices. J Pharm Pharm Sci. 2000;3:234–58.
Vasir JK, Tambwekar K, Garg S. Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm. 2003;255:13–32.
Min Q, Liu J, Li J, Wan Y, Wu J. Chitosan-polylactide/hyaluronic acid complex microspheres as carriers for controlled release of bioactive transforming growth factor-β1. Pharmaceutics. 2018;10:239.
dos Santos B, Maciel M, Tavares AA, de Araújo Fernandes CQB, de Sousa WB, Lia Fook M, et al. Synthesis and preparation of chitosan/clay microspheres: effect of process parameters and clay type. Materials. 2018;11:2523.
Galindo-Rodríguez SA, Puel F, Briançon S, Allémann E, Doelker E, Fessi H. Comparative scale-up of three methods for producing ibuprofen-loaded nanoparticles. Eur J Pharm Sci. 2005;25:357–67.
Huynh NT, Passirani C, Saulnier P, Benoit JP. Lipid nanocapsules: a new platform for nanomedicine. Int J Pharm. 2009;379:201–9.
de Freitas LM, Calixto GMF, Chorilli M, Giusti JSM, Bagnato VS, Soukos NS, et al. Polymeric nanoparticle-based photodynamic therapy for chronic periodontitis in vivo. Int J Mol Sci. 2016;17:769.
Wu J, Wang Y, Yang H, Liu X, Lu Z. Preparation and biological activity studies of resveratrol loaded ionically cross-linked chitosan-TPP nanoparticles. Carbohydr Polym. 2017;175:170–7.
Cerchiara T, Abruzzo A, di Cagno M, Bigucci F, Bauer-Brandl A, Parolin C, et al. Chitosan based micro-and nanoparticles for colon-targeted delivery of vancomycin prepared by alternative processing methods. Eur J Pharm Biopharm. 2015;92:112–9.
Karki S, Kim H, Na SJ, Shin D, Jo K, Lee J. Thin films as an emerging platform for drug delivery. Asian J Pharm Sci. 2016;11:559–74.
Devi N, Dutta J. Preparation and characterization of chitosan-bentonite nanocomposite films for wound healing application. Int J Biol Macromol. 2017;104:1897–904.
Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K. The development of microgels/nanogels for drug delivery applications. Prog Polym Sci. 2008;33:448–77.
Zha L, Banik B, Alexis F. Stimulus responsive nanogels for drug delivery. Soft Matter. 2011;7:5908–16.
García MC, Cuggino JC. Stimulus-responsive nanogels for drug delivery. In Stimuli responsive polymeric Nanocarriers for drug delivery applications. 2018;l:321–341.
WU S-W, et al. Strengthening injectable thermo-sensitive NIPAAm-g-chitosan hydrogels using chemical cross-linking of disulfide bonds as scaffolds for tissue engineering. Carbohydr Polym. 2018;192:308–16.
CHEN Y, et al. Preparation of the chitosan/poly (glutamic acid)/alginate polyelectrolyte complexing hydrogel and study on its drug releasing property. Carbohydr Polym. 2018;191:8–16.
Raab O. Uber die Wirkung fluorescierender Stoffe auf Infusoria. Z Biol. 1900;39:524 26.
Jesionek A, Tcppeiner v H. Dtsch Arch Klin Med. 1905;85:223–39.
Jodlbauer A, Tappeiner von H, Munch Med Wochenschr. Uber die Wirkung photodynamischer (fluoreszierender) Stoffe auf Bakterien. 1904;51:1096–7.
Santezi C, Reina BR, Dovigo LN. Curcumin-mediated photodynamic therapy for the treatment of oral infections—a review. Photodiagn Photodyn Ther. 2018;21:409–15.
Wainwright M, Maisch T, Nonell S, Plaetzer K, Almeida A, Tegos GP, et al. Photoantimicrobials-are we afraid of the light? Lancet Infect Dis. 2017;17:1–14.
Kharkwal GB, Sharma SK, Huang YY, Dai T, Hamblin MR. Photodynamic therapy for infections: clinical applications. Lasers Surg Med. 2011;43:755–67.
Allison RR, Moghissi K. Photodynamic therapy (pdt): pdt mechanisms. Clin Endosc. 2013;46:24–9.
Scherer KM, Bisby RH, Botchway SW, Parker AW. New approaches to photodynamic therapy from types I, II and III to type IV using one or more photons. Anti Cancer Agents Med Chem. 2017;17:171–89.
Chen C, Wang J, Li X, Liu X, Han X. Recent advances in developing photosensitizers for photodynamic cancer therapy. Comb Chem High Throughput Screen. 2017;20:414–22.
Sibata CH, Colussi VC, Oleinick NL, Kinsella TJ. Photodynamic therapy: a new concept in medical treatment. Braz J Med Biol Res. 2000;33:869–880, 2000.
Machado AEH. Photodynamic therapy: principles, application potential and perspectives. Quim Nova. 2000;23:237–43.
Allison RR, Downie GH, Cuenca R, Hu X, Carter JHC, Sibata CH. Photosensitizers in clinical PDT. Photodiagnosis Photodyn Ther. 2004;1:27–42.
Nagata JY, Hioka N, Kimura E, Batistela VR, Terada RS, Graciano AX, et al. Antibacterial photodynamic therapy for dental caries: evaluation of the photosensitizers used and light source properties. Photodiagnosis Photodyn Ther. 2012;9:122–31.
Yin R, Hamblin MR. Antimicrobial photosensitizers: drug discovery under the spotlight. Curr Med Chem. 2015;22(18):2159–85.
Baskaran R, Junghan L, Yang S. Clinical development of photodynamic agents and therapeutic applications. Biomater Res. 2018;22:3–8.
Simplicio FI, Maionchi F, Hioka N. Photodynamic therapy: pharmacological aspects, applications, and recent developments in drug development. Quim Nova. 2002;25:801–7.
Triesscheijn M, Baas P, Schellens JHM, Stewart FA. Photodynamic therapy in oncology. Oncologist. 2006;11:1034–44.
Zheng Huang MD. An update on the regulatory status of PDT photosensitizers in China. Photodiagn Photodyn Ther. 2008;5:285–7.
Allison RR, Sibata CH. Oncologic photodynamic therapy photosensitizers: a clinical review. Photodiagn Photodyn Ther. 2010;7:61–75.
Sekkat N, van den Bergh H, Nyokong T, Lange N. Like a bolt in the blue: phthalocyanines in biomedical optics. Molecules. 2012;17:98–144.
Ormond AB, Freeman HS. Dye sensitizers for photodynamic therapy. Materials. 2013;6:817–40.
De Oliveira KT, de Souza JM, Gobo NRS, de Assis FF, Brocks TJ. Fundamental concepts and applications of porphyrins, chlorines and Phthalocyanines photosensitizers in photonic therapies. Rev Virtual Quim. 2015;7:310–35.
De Oliveira KT, Momo PB, de Assis FF, Ferreira MAB, Brocksom TJ. Chlorins: natural sources, synthetic developments and main applications. Curr Org Synth. 2014;11:42.
Kawczyk-Krupka A, Wawrzyniec K, Musiol SK, Potempa M, Bugaj AM, Sieron A. Treatment of localized prostate cancer using WST-09 and WST-11 mediated vascular targeted photodynamic therapy-a review. Photodiagn Photodyn Ther. 2015;12:567–74.
Azzouzi AR, Vincendeau S, Barret E, Cicco A, Kleinclauss F, van der Poel HG, et al. Padeliporfin vascular-targeted photodynamic therapy versus active surveillance in men with low-risk prostate cancer (CLIN1001 PCM301): an open-label, phase 3, randomised controlled trial. Lancet Oncol. 2017;18:181–91.
Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003;3:380–7.
Mroz P, Yaroslavsky A, Kharkwal GB, Hamblin MR. Cell death pathways in photodynamic therapy of cancer. Cancers. 2011;3:2516–39.
Brown SB, Brown EA, Walker I. The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol. 2004;5:497–8.
Abrahamse H, Hamblin MR. New photosensitizers for photodynamic therapy. Biochem J. 2016;473:347–64.
Hamblin MR. Potentiation of antimicrobial photodynamic inactivation by inorganic salts. Expert Rev Anti-Infect Ther. 2017;15:1059–69.
Hamblin MR. Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes. Curr Opin Microbiol. 2016;33:67–73.
Baltazar LM, Krausz AE, Souza AC, Adler BL, Landriscina A, Musaev T, et al. Trichophyton rubrum is inhibited by free and nanoparticle encapsulated curcumin by induction of nitrosative stress after photodynamic activation. PLoS One. 2015;10:1–14.
Havlickova B, Czaika VA, Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycoses. 2008;51:2–15.
Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC. Hidden killers: human fungal infections. Sci Transl Med. 2012;19:1–10.
Cowen LE, Sanglard D, Howard SJ, Rogers PD, Perlin DS. Mechanisms of antifungal drug resistance. Cold Spring Harb Perspect Med. 2015;5:1–22.
Kathiravan MK, Salake AB, Chothe AS, Dudhe PB, Watode RP, Mukta MS, et al. The biology and chemistry of antifungal agents: a review. Bioorg Med Chem. 2012;20:5678–98.
Cowen LE. The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. Nat Rev Microbiol. 2008;6:187–98.
Perlin DS, Rautemaa-Richardson R, Alastruey-Izquierdo A. The global problem of antifungal resistance: prevalence, mechanisms, and management. Lancet Infect Dis. 2017;17:1–10.
Morschhauser J, Barker K, Liu T, Bla B, Homayouni R, Rogers P. The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans. PLoS Pathog. 2007;3:1603–16.
Vale-Silva LA, Coste AT, Ischer F, et al. Azole resistance by loss of function of the sterol Δ(5),(6)-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulence. Antimicrob Agents Chemother. 2012;56:1960–8.
Bonhomme J, d’Enfert C. Candida albicans biofilms: building a heterogeneous, drug-tolerant environment. Curr Opin Microbiol. 2013;16:398–3.
Andrade MC, Ribeiro APD, Dovigo LN, Brunetti IL, Giampaolo ET, Bagnato VS, et al. Effect of different pre-irradiation times on curcumin-mediated photodynamic therapy against planktonic cultures and biofilms of Candida spp. Arch Oral Biol. 2013;58:200–10.
Dovigo LN, Carmello JC, De Sousa CCA, Vergani CE, Brunetti IL, Bagnato VS, et al. Curcumin-mediated photodynamic inactivation of Candida albicans in a murine model of oral candidiasis. Med Mycol. 2013;51:243–51.
Sanitá PV, Pavarina AC, Dovigo LN, Ribeiro APD, Carvalho M, Mima EGDO. Curcumin-mediated anti-microbial photodynamic therapy against Candida dubliniensis biofilms. Lasers Med Sci. 2017;33:709–17.
Dovigo LN, Carmello JC, Carvalho MT, Mima EG, Vergani CE, Bagnato VS, et al. Photodynamic inactivation of clinical isolates of Candida using Photodithazine ®. Biofouling. 2013;29:1–11.
Carmello JC, Dovigo LN, Mima EG, Jorge JH, De Souza CAC, Bagnato VS, et al. In vivo evaluation of photodynamic inactivation using Photodithazine® against Candida albicans. Photochem Photobiol Sci. 2015;14:1319–28.
Carmello JC, Alves F, Basso F, De Souza CAC, Bagnato VS, Mima EGO, et al. Treatment of oral candidiasis using Photodithazine®- mediated photodynamic therapy in vivo. Plosone. 2016;11:1–18.
Alves F, Alonso GC, Carmello JC, Mima EGO, Bagnato VS, Pavarina AC. Antimicrobial photodynamic therapy mediated by Photodithazine® in the treatment of denture stomatitis: a case report. Photodiagn Photodyn Ther. 2018;21:168–71.
Alves F, Mima EGO, Passador RCP, Bagnato VS, JORGE JH, Pavarina AC. Virulence factors of fluconazole-susceptible and fluconazole-resistant Candida albicans after antimicrobial photodynamic therapy. Lasers Med Sci. 2017;32:815–26.
Machado-de-Sena RM, Corrêa L, Kato IT, Prates RA, Senna AM, Santos CC, et al. Photodynamic therapy has antifungal effect and reduces inflammatory signals in Candida albicans-induced murine vaginitis. Photodiagn Photodyn Ther. 2014;11:275–82.
Alves F, Mima EG, Dovigo LN, Bagnato VS, Jorge JH, DE Sousa CAC, et al. The influence of photodynamic therapy parameters on the inactivation of Candida spp: in vitro and in vivo studies. Laser Phys. 2014;24:1–8.
Černáková L, Chupáčová J, Židlíková K, Bujdáková H. Effectiveness of the photoactive dye Methylene Blue versus Caspofungin on the Candida parapsilosis biofilm in vitro and ex vivo. Photochem Photobiol. 2015;91:1181–90.
Cernáková L, Dižová S, Bujdáková H. Employment of methylene blue irradiated with laser light source in photodynamic inactivation of biofilm formed by Candida albicans strain resistant to fluconazole. Med Mycol. 2017;55:748–53.
Pinto AP, Rosseti IB, Carvalho ML, Da Silva BGM, Alberto-Silva C, Costa MS. Photodynamic antimicrobial chemotherapy (PACT), using Toluidine blue O inhibits the viability of biofilm produced by Candida albicans at different stages of development. Photodiagn Photodyn Ther. 2018;21:182–9.
Da Silva BGM, Carvalho ML, Rosseti IB, Zamuner S, Costa MS. Photodynamic antimicrobial chemotherapy (PACT) using toluidine blue inhibits both growth and biofilm formation by Candida krusei. Lasers Med Sci. 2018;33:983–90.
Carpenter BL, Situ X, Scholle F, Bartelmess J, Weare WW, Ghiladi RA. Antiviral, antifungal and antibacterial activities of a BODIPY-based photosensitizer. Molecules. 2015;20:10604–21.
Soares BM, Alves OA, Ferreira MV, Amorim JC, Sousa GR, Silveira Lde B, et al. Cryptococcus gattii: in vitro susceptibility to photodynamic inactivation. Photochem Photobiol. 2011;87:357–64.
Srikanta D, Santiago-Tirado FH, Doering TL. Cryptococcus neoformans: historical curiosity to modern pathogen. Yeast. 2014;31:47–60.
Smijs TG, Pavel S. The susceptibility of dermatophytes to photodynamic treatment with special focus on Trichophyton rubrum. Photochem Photobiol. 2011;87:2–13.
Baltazar LM, Soares BM, Carneiro HC, Avila TV, Gouveia LF, Souza DG, et al. Photodynamic inhibition of Trichophyton rubrum: in vitro activity and the role of oxidative and nitrosative bursts in fungal death. J Antimicrob Chemother. 2013;68:354–61.
Paz-Cristobal MP, Gilaberte Y, Alejandre C, Pardo J, Revillo MJ, Rezusta A. In vitro fungicidal photodynamic effect of hypericin on Trichophyton spp. Mycopathologia. 2014;178:221–5.
Souza LW, Souza SV, Botelho AC. Distal and lateral toenail onychomycosis caused by Trichophyton rubrum: treatment with photodynamic therapy based on methylene blue dye. An Bras Dermatol. 2014;89:184–6.
Shamali N, Preuß A, Saltsman I, Mahammed A, Gross Z, Däschlein G, et al. In vitro photodynamic inactivation (PDI) of pathogenic germs inducing onychomycosis. Photodiagn Photodyn Ther. 2018;24:358–65.
Kim JR, Michielsen S. Photodynamic activity of nanostructured fabrics grafted with xanthene and thiazine dyes against opportunistic fungi. J Photochem Photobiol B. 2015;150:50–9.
Arboleda A, Miller D, Cabot F, Taneja M, Aguilar MC, Alawa K, et al. Assessment of rose bengal versus riboflavin photodynamic therapy for inhibition of fungal keratitis isolates. Am J Ophthalmol. 2014;158:64–70.
Gaitanis G, Velegraki A, Mayser P, Bassukas ID. Skin diseases associated with Malassezia yeasts: facts and controversies. Clin Dermatol. 2013;31:455–63.
Takahashi H, Nakajima S, Sakata I, Iizuka H. Antifungal effect of TONS504-photodynamic therapy on Malassezia furfur. J Dermatol. 2014;41:895–7.
Sueoka K, Chikama T, Pertiwi YD, Ko JA, Kiuchi Y, Sakaguchi T, et al. Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi. Lasers Med Sci. 2018. https://doi.org/10.1007/s10103-018-2654-y.
Verlee A, Mincke S, Stevens CV. Recent developments in antibacterial and antifungal chitosan and its derivatives. Carbohydr Polym. 2017;16:268–83.
Palma-Guerrero J, Lopez-Jimenez J, Pérez-Berná AJ, Huang IC, Jansson HB, Salinas J, et al. Membrane fluidity determines sensitivity of filamentous fungi to chitosan. Mol Microbiol. 2010;75:1021–32.
Dovigo LN, Pavarina AC, Mima EG, Giampaolo ET, Vergani CE, Bagnato VS. Fungicidal effect of photodynamic therapy against fluconazole-resistant Candida albicans and Candida glabrata. Mycoses. 2011;54:123–30.
Baltazar LM, Ray A, Santos DA, Cisalpino PS, Friedman AJ, Nosanchuk JD. Antimicrobial photodynamic therapy: an effective alternative approach to control fungal infections. Front Microbiol. 2015;6:1–11.
Chen CP, Chen CT, Tsai T. Chitosan nanoparticles for antimicrobial photodynamic inactivation: characterization and in vitro investigation. Photochem Photobiol. 2012;88:570–6.
Chien HF, Chen CP, Chen YC, Chang PH, Tsai T, Chen CT. The use of Chitosan to enhance photodynamic inactivation against Candida albicans and its drug-resistant clinical isolates. Int J Mol Sci. 2013;14:7445–56.
Fabio CA, Yolanda MB, Carmen GM, Francisco C, Antonio Julián B, Leonor PL, et al.Use of photodynamic therapy and chitosan for inactivacion of Candida albicans in a murine model. 2016; 45:627–33.
Zeina B, Greenman J, Purcell WM, Das B. Killing of cutaneous microbial species by photodynamic therapy. Br J Dermatol. 2001;144:274–8.
Woolhouse M, Gaunt E. Ecological origins of novel human pathogens. Crit Rev Microbiol. 2007;33:1–12.
Smith KF, Guégan JF. Changing geographic distributions of human pathogens. Annu Rev Ecol Evol Syst. 2010;41:231–50.
Kashef N, Hamblin MR. Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation. Drug Resist Updat. 2017;31:31–42.
WHO, World Health Organization. Available from: Antimicrobial resistance Fact Sheet: http://www.who.int/mediacentre/factsheets/fs194/en/. Accessed 15 Jan 2018.
Dai T, Gupta A, Murray CK, Vrahas MS, Tegos GP, Hamblin MR. Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond? Drug Resist Updat. 2012;15:223–36.
Casas A, Di Venosa G, Hasan T, Batlle A. Mechanisms of resistance to photodynamic therapy. Curr Med Chem. 2011;18:2486–515.
Weiss K, Tillotson GS. The controversy of combination vs monotherapy in the treatment of hospitalized community-acquired pneumonia. Chest. 2005;128:940–6.
Cole ST. Who will develop new antibacterial agents? Philos Trans R Soc B. 2014;369:20130430.
Meimandi M, Talebi Ardakani MR, Esmaeil Nejad A, Yousefnejad P, Saebi K, Tayeed MH. The effect of photodynamic therapy in the treatment of chronic periodontitis: a review of literature. J Lasers Med Sci. 2017;8:S7–11.
Yuan Y, Liu ZQ, Jin H, Sun S, Liu TJ, Wang X, et al. Photodynamic antimicrobial chemotherapy with the novel amino acid-porphyrin conjugate 4I: in vitro and in vivo studies. PLoS One. 2017;12:E0176529.
Maisch T, Hackbarth S, Regensburger J, Felgenträger A, Bäumler W, Landthaler M, et al. Photodynamic inactivation of multi-resistant bacteria (PIB)–a new approach to treat superficial infections in the 21st century. J Dtsch Dermatol Ges. 2011;9:360–6.
Tim M. Strategies to optimize photosensitizers for photodynamic inactivation of bacteria. J Photochem Photobiol B. 2015;150:2–10.
Branco TM, Valério NC, Jesus VIR, Dias CJ, Neves MG, Faustino MA, et al. Single and combined effects of photodynamic therapy and antibiotics to inactivate Staphylococcus aureus on skin. Photodiagn Photodyn Ther. 2018;21:285–93.
Gao Y, Mai B, Wang A, Li M, Wang X, Zhang K, et al. Antimicrobial properties of a new type of photosensitizer derived from phthalocyanine against planktonic and biofilm forms of Staphylococcus aureus. Photodiagn Photodyn Ther. 2018;21:316–26.
Zhang QZ, Zhao KQ, Wu Y, Li XH, Yang C, Guo LM, et al. 5-Aminolevulinic acid-mediated photodynamic therapy and its strain-dependent combined effect with antibiotics on Staphylococcus aureus biofilm. PLoS One. 2017;12:E0174627.
Deleo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010;375:1557–68.
Gould IM. VRSA—doomsday superbug or damp squib? Lancet Infect Dis. 2010;10:816–8.
St. Denis T, Dai T, Izikson L, Astrakas C, Anderson RR, Hamblin MR, et al. All you need is light: antimicrobial photoinactivation as na evolving and emerging discovery strategy against infectious disease. Virulence. 2011;2:6.
Iluz N, Maor Y, Keller N, Malik Z. The synergistic effect of PDT and oxacillin on clinical isolates of Staphylococcus aureus. Lasers Surg Med. 2018;50:535–51.
Park JH, Ahn MY, Kim YC, Kim SA, Moon YH, Ahn SG, et al. In vitro and in vivo antimicrobial effect of photodynamic therapy using a highly pure chlorin e6 against Staphylococcus aureus Xen29. Biol Pharm Bull. 2012;35:509–14.
Uliana MP, Pires L, Pratavieira S, Brocksom TJ, de Oliveira KT, Bagnato VS, et al. Photobiological characteristics of chlorophyll a derivatives as microbial PDT agents. Photochem Photobiol Sci. 2014;13:1137–45.
Mai B, Wang X, Liu Q, Leung AW, Wang X, Xu C, et al. The antibacterial effect of sinoporphyrin sodium photodynamic therapy on Staphylococcus aureus planktonic and biofilm cultures. Lasers Surg Med. 2016;48:400–8.
Winkler K, Simon C, Finke M, Bleses K, Birke M, Szentmáry N, et al. Photodynamic inactivation of multidrug-resistant Staphylococcus aureus by chlorin e6 and red light (λ=670nm). J Photochem Photobiol B. 2016;162:340–7.
Giannelli M, Landini G, Materassi F, Chellini F, Antonelli A, Tani A, et al. Effects of photodynamic laser and violet-blue led irradiation on Staphylococcus aureus biofilm and Escherichia coli lipopolysaccharide attached to moderately rough titanium surface: in vitro study. Lasers Med Sci. 2017;32:857–64.
Bhavya ML, Hebbar HU. Efficacy of blue LED in microbial inactivation: effect of photosensitization and process parameters. Int J Food Microbiol. 2019;290:296–304.
Araújo TSD, Rodrigues PLF, Santos MS, de Oliveira JM, Rosa LP, Bagnato VS, et al. Reduced methicillin-resistant Staphylococcus aureus biofilm formation in bone cavities by photodynamic therapy. Photodiagn Photodyn Ther. 2018;21:219–23.
Liu J, Yu M, Zeng G, Cao J, Wang Y, Ding T, et al. Dual antibacterial behaviors of curcumin-upconversion photodynamic nanosystem for efficient eradicating drug-resistant bacteria in deep joint infection. J Mater Chem B. 2018;6:7854–61.
Zhao KQ, Wu Y, Yi YX, Feng SJ, Wei RY, Ma Y, et al. An in vitro model to study the effect of 5-aminolevulinic acid-mediated photodynamic therapy on Staphylococcus aureus biofilm. J Vis Exp. 2018;134:E57604–e57604.
Chevalier S, Bouffartigues E, Bodilis J, Maillot O, Lesouhaitier O, Feuilloley MGJ, et al. Structure, function and regulation of Pseudomonas aeruginosa porins. FEMS Microbiol Rev. 2017;41:698–722.
Miyoshi-Akiyama T, Tada T, Ohmagari N, Viet Hung N, Tharavichitkul P, Pokhrel BM, et al. Emergence and spread of epidemic multidrug-resistant Pseudomonas aeruginosa. Genome Biol Evol. 2017;9:3238–45.
Viedma E, Juan C, Acosta J, Zamorano L, Otero JR, Sanz F, et al. Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum β-lactamases GES-1 and GES-5 in Spain. Antimicrob Agents Chemother. 2009;53:4930–3.
Park JH, Moon YH, Bang IS, Kim YC, Kim SA, Ahn SG, et al. Antimicrobial effect of photodynamic therapy using a highly pure chlorin e6. Lasers Med Sci. 2010;25:705–10.
Yang SM, Lee DW, Park HJ, Kwak MH, Park JM, Choi MG. Hydrogen peroxide enhances the antibacterial effect of methylene blue-based photodynamic therapy on biofilm-forming bacteria. Photochem Photobiol. 2018. https://doi.org/10.1111/php.13056.
Pereira AHC, Pinto JG, Freitas MAA, Fontana LC, Pacheco Soares C, Ferreira-Strixino J. Methylene blue internalization and photodynamic action against clinical and ATCC Pseudomonas aeruginosa and Staphyloccocus aureus strains. Photodiagn Photodyn Ther. 2018;22:43–50.
Prochnow EP, Martins MR, Campagnolo CB, Santos RC, Villetti MA, Kantorski KZ. Antimicrobial photodynamic effect of phenothiazinic photosensitizers in formulations with ethanol on Pseudomonas aeruginosa biofilms. Photodiagn Photodyn Ther. 2016;13:291–6.
Tan Y, Cheng Q, Yang H, Li H, Gong N, Liu D, et al. Effects of ALA-PDT on biofilm structure, virulence factor secretion, and QS in Pseudomonas aeruginosa. Photodiagnosis Photodyn Ther. 2018;24:88–94.
Topaloglu N, Guney M, Aysan N, Gulsoy M, Yuksel S. The role of reactive oxygen species in the antibacterial photodynamic treatment: photoinactivation vs proliferation. Lett Appl Microbiol. 2016;62:230–6.
Orlandi VT, Rybtke M, Caruso E, Banfi S, Tolker-Nielsen T, Barbieri P. Antimicrobial and anti-biofilm effect of a novel BODIPY photosensitizer against Pseudomonas aeruginosa PAO1. Biofouling. 2014;30:883–91.
De Freitas LM, Lorenzón EM, Santos-Filho NA, Zago LHDP, Uliana MP, De Oliveira KT, et al. Antimicrobial photodynamic therapy enhanced by the peptide aurein 1.2. Sci Rep. 2018;8:4212.
Dworniczek E, Piwowarczyk J, Seniuk A, Gościniak G. Enterococcus–virulence and susceptibility to photodynamic therapy of clinical isolates from Lower Silesia, Poland. Scand J Infect Dis. 2014;46:846–53.
Chibebe Junior J, Fuchs BB, Sabino CP, Junqueira JC, Jorge AO, Ribeiro MS, et al. Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model. PLoS One. 2013;8:E55926.
Ragàs X, Dai T, Tegos GP, Agut M, Nonell S, Hamblin MR. Photodynamic inactivation of Acinetobacter baumannii using phenothiazinium dyes: in vitro and in vivo studies. Lasers Surg Med. 2010;42:384–90.
Caruso E, Banfi S, Barbieri P, Leva B, Orlandi VT. Synthesis and antibacterial activity of novel cationic BODIPY photosensitizers. J Photochem Photobiol B. 2012;114:44–51.
Edwards L, Turner D, Champion C, Khandelwal M, Zingler K, Stone C, et al. Photoactivated 2, 3-distyrylindoles kill multi-drug resistant bacteria. Bioorg Med Chem Lett. 2018;28:1879–86.
Misba L, Zaidi S, Khan AU. A comparison of antibacterial and antibiofilm efficacy of phenothiazinium dyes between Gram positive and Gram negative bacterial biofilm. Photodiagn Photodyn Ther. 2017;18:24–33.
de Annunzio SR, de Freitas LM, Blanco A, da Costa MM, Carmona-Vargas CC, de Oliveira KT, et al. Susceptibility of Enterococcus faecalis and Propionibacterium acnes to antimicrobial photodynamic therapy. J Photochem Photobiol B. 2018;178:545–50.
Hosseinnejad M, Jafari SM. Evaluation of different factors affecting antimicrobial properties of chitosan. Int J Biol Macromol. 2016;85:467–75.
Shrestha A, Kishen A. The effect of tissue inhibitors on the antibacterial activity of chitosan nanoparticles and photodynamic therapy. J Endod. 2012;38:1275–8.
Verlee A, Mincke S, Stevens CV. Recent developments in antibacterial and antifungal chitosan and its derivatives. Carbohydr Polym. 2017;164:268–83.
Tsai T, Chien H, Wang T, Huang C, Ker Y, Chen C. Chitosan augments photodynamic inactivation of gram-positive and gram-negative bacteria. Antimicrob Agents Chemother. 2011;55:1883–90.
Kong M, Chen XG, Xing K, Park HJ. Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol. 2010;144:51–63.
Helander IM, Nurmiaho-Lassila EL, Ahvenainen R, Rhoades J, Roller S. Chitosan disrupts the barrier properties of the outer membrane of Gram-negative bacteria. Int J Food Microbiol. 2001;71:235–44.
Xing R, Yu H, Liu S, Zhang W, Zhang Q, Li Z, et al. Antioxidant activity of differently regioselective chitosan sulfates in vitro. Bioorg Med Chem. 2005;13:1387–92.
Rabea EI, Badawy ME, Stevens CV, Smagghe G, Steurbaut W, et al. Chitosan as antimicrobial agent: applications and mode of action. Biomacromolecules. 2003;4:1457–65.
Peña A, Sánchez NS, Calahorra M. Effects of chitosan on Candida albicans: conditions for its antifungal activity. Biomed Res Int. 2013;2013:527549.
Upadya M, Shrestha A, Kishen A. Role of efflux pump inhibitors on the antibiofilm efficacy of calcium hydroxide, chitosan nanoparticles, and light-activated disinfection. J Endod. 2011;37:1422–6.
Shrestha C. Effect of photodynamic therapy using hexyl aminolevulinate and Amphinex–in vitro and in vivo studies. http://hdl.handle.net/11250/263552 (2011).
Sperandio FF, Huang YY, Hamblin MR. Antimicrobial photodynamic therapy to kill Gram-negative bacteria. Recent Pat Antiinfect Drug Discov. 2013;8:108–20.
Shrestha TB, Seo GM, Basel MT, Kalita M, Wang H, Villanueva D, et al. Stem cell-based photodynamic therapy. Photochem Photobiol Sci. 2012;11:1251–8.
Shrestha A, Kishen A. Polycationic chitosan-conjugated photosensitizer for antibacterial photodynamic therapy. Photochem Photobiol. 2012;88:577–83.
Da Silva L, Finer Y, Friedman S, Basrani B, Kishen A. Biofilm formation within the interface of bovine root dentin treated with conjugated chitosan and sealer containing chitosan nanoparticles. J Endod. 2013;39:249–53.
Nagahara A, Mitani A, Fukuda M, Yamamoto H, Tahara K, Morita I, et al. Antimicrobial photodynamic therapy using a diode laser with a potential new photosensitizer, indocyanine green-loaded nanospheres, may be effective for the clearance of Porphyromonas gingivalis. J Periodontal Res. 2013;48:591–9.
Choi SS, Lee HK, Chae HS. Synergistic in vitro photodynamic antimicrobial activity of methylene blue and chitosan against Helicobacter pylori 26695. Photodiagnosis Photodyn Ther. 2014;11:526–32.
Chen CP, Hsieh CM, Tsai T, Yang JC, Chen CT. Optimization and evaluation of a Chitosan/hydroxypropyl methylcellulose hydrogel containing toluidine blue O for antimicrobial photodynamic inactivation. Int J Mol Sci. 2015;16:20859–72.
Darabpour E, Kashef N, Mashayekhan S. Chitosan nanoparticles enhance the efficiency of methylene blue-mediated antimicrobial photodynamic inactivation of bacterial biofilms: an in vitro study. Photodiagn Photodyn Ther. 2016;14:211–7.
Peng PC, Hsieh CM, Chen CP, Tsai T, Chen CT. Assessment of photodynamic inactivation against periodontal bacteria mediated by a chitosan hydrogel in a 3D gingival model. Int J Mol Sci. 2016;17(11).
Camacho-Alonso F, Julián-Belmonte E, Chiva-García F, Martínez-Beneyto Y. Bactericidal efficacy of photodynamic therapy and Chitosan in root canals experimentally infected with enterococcus faecalis: an in vitro study. Photomed Laser Surg. 2017;35:184–9.
Theodoratou E, Timofeeva M, Li X, Meng X, Ioannidis JPA. Nature, nurture, and cancer risks: genetic and nutritional contributions to cancer. Send to Annu Rev Nutr. 2017;37:293–320.
Chilakamarthi U, Giribabu L. Photodynamic therapy: past, present and future. Chem Rec. 2017;17:775–802.
De Grand AM, Frangioni JV. An operational near-infrared fluorescence imaging system prototype for large animal surgery. Technol Cancer Res Treat. 2003;2:553–62.
Diaz EM Jr, Sturgis EM, Laramore GE, Sabichi AL, Lippman SM, Clayman G. Holland-freicancer Medicine. 6th edition. Hamilton: BC Decker; 2003.
King PD, Perry MC. Hepatotoxicity of chemotherapy. Oncologist. 2001;6:162–76.
Lee SJ, Koo H, Jeong H, Huh MS, Choi Y, Jeong SY, et al. Comparative study of photosensitizer loaded and conjugated glycol chitosan nanoparticles for cancer therapy. J Control Release. 2011;152:21–9.
Ghaz-Jahanian MA, Abbaspour-Aghdam F, Anarjan N, Berenjian A, Jafarizadeh-Malmiri H. Application of chitosan-based nanocarriers in tumor-targeted drug delivery. Mol Biotechnol. 2015;57:201–18.
Simone CB, Cengel KA. Photodynamic therapy for lung cancer and malignant pleural mesothelioma. Semin Oncol. 2014;41:820–30.
Baldea I, Filip A. Photodynamic therapy in melanoma—an update. J Physiol Pharmacol. 2012;63:109–18.
Dolmans DEJGJ, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003;3:380–7.
Gao H, Shi L, Yin H, Wang H, Shen J, Wang C, et al. Evaluation of the effect of photodynamic therapy with hematoporphyrin monomethyl ether on VX2 tumors implanted in the rectal submucosa of rabbits. J Photochem Photobiol B. 2016;163:162–9.
Yano T, Kasai H, Horimatsu T, Yoshimura K, Teramukai S, Morita S. A multicenter phase II study of salvage photodynamic therapy using talaporfin sodium (ME2906) and a diode laser (PNL6405EPG) for local failure after chemoradiotherapy or radiotherapy for esophageal cancer. Oncotarget. 2017;8:22135–44.
Zhang X, Cai L, He J, Li X, Li L, Chen X, et al. Influence and mechanism of 5-aminolevulinic acid-photodynamic therapy on the metastasis of esophageal carcinoma. Photodiagn Photodyn Ther. 2017;20:78–85.
Srdanović S, Gao YH, Chen DY, Yan YJ, Margetić D, Chen ZL. The photodynamic activity of 131-[2′-(2-pyridyl)ethylamine] chlorin e6 photosensitizer in human esophageal cancer. Bioorg Med Chem Lett. 2018;28:1785–91.
Cramer G, Shin M, Hagan S, Katz SI, Simone CB 2nd, Busch TM, et al. Modeling epidermal growth factor inhibitor-mediated enhancement of photodynamic therapy efficacy using 3D mesothelioma cell culture. Photochem Photobiol. 2018:1–9.
Cheng YS, Peng YB, Yao M, Teng JP, Ni D, Zhu ZJ, et al. Cisplatin and photodynamic therapy exert synergistic inhibitory effects on small-cell lung cancer cell viability and xenograft tumor growth. Biochem Biophys Res Commun. 2017;487:567–72.
Van Doeveren TEM, Karakullukçu MB, van Veen RLP, Lopez-Yurda M, Schreuder WH, Tan IB. Adjuvant photodynamic therapy in head and neck cancer after tumor-positive resection margins. Laryngoscope. 2018;128:657–63.
Hodgkinson N, Kruger CA, Mokwena M, Abrahamse H. Cervical cancer cells (hela) response to photodynamic therapy using a zinc phthalocyanine photosensitizer. J Photochem Photobiol B. 2017;177:32–8.
De Freitas LM, Serafim RB, de Sousa JF, Moreira TF, Dos Santos CT, Baviera AM, et al. Photodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells. BMC Cancer. 2017;17:1–12.
Inoue K. 5-Aminolevulinic acid-mediated photodynamic therapy for bladder cancer. Int J Urol. 2017;24:97–101.
Ohulchanskyy TY, Roy I, Goswami LN, Chen Y, Bergey EJ, Pandey RK, et al. Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer. Nano Lett. 2007;7:2835–42.
Sun Y, Chen ZL, Yang XX, Huang P, Zhou XP, Du XX. Magnetic chitosan nanoparticles as a drug delivery system for targeting photodynamic therapy. 2009;20:1–8.
Jabr-Milane LS, van Vlerken LE, Yadav S, Amiji MM. Multi-functional nanocarriers to overcome tumor drug resistance. Cancer Treat Rev. 2008;34:592–602.
Kim K, Kim JH, Park H, Kim YS, Park K, Nam H, et al. Tumor-homing multifunctional nanoparticles for cancer theragnosis: simultaneous diagnosis, drug delivery, and therapeutic monitoring. J Control. 2010;146:219–27.
Calixto GM, Bernegossi J, de Freitas LM, Fontana CR, Chorilli M. Nanotechnology-based drug delivery systems for photodynamic therapy of cancer: a review. Molecules. 2016;21:342.
Costa Idos S, Abranches RP, Garcia MT, Pierre MB. Chitosan-based mucoadhesive films containing 5-aminolevulinic acid for buccal cancer's treatment. J Photochem Photobiol B. 2014;140:266–75.
Filip A, Clichici S, Muresan A, Daicoviciu D, Tatomir C, Login C, et al. Effects of pdt with 5-aminolevulinic acid and chitosan on walker carcinosarcoma. Exp Oncol. 2008;30:212–9.
Shen L, Huang Y, Chen D, Qiu F, Ma C, Jin X, et al. Ph-responsive aerobic nanoparticles for effective photodynamic therapy. Theranostics. 2017;7:4537–50.
Battogtokh G, Gotov O, Kang JH, Hong EJ, Shim MS, Shin D, et al. Glycol chitosan-coated near-infrared photosensitizer-encapsulated gold nanocages for glioblastoma phototherapy. Nanomedicine. 2018;30544-6:S1549–9634.
Keyal U, Luo Q, Bhatta AK, Luan H, Zhang P, Wu Q, et al. Zinc pthalocyanine-loaded chitosan/mpeg-PLA nanoparticles-mediated photodynamic therapy for the treatment of cutaneous squamous cell carcinoma. J Biophotonics. 2018;e201800114:1–15.
Tsai WH, Yu KH, Huang YC, Lee CI. EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles. Int J Nanomedicine. 2018;13:903–16.
Belali S, Karimi AR, Hadizadeh M. Cell-specific and ph-sensitive nanostructure hydrogel based on chitosan as a photosensitizer carrier for selective photodynamic therapy. Int J Biol Macromol. 2018;110:437–48.
Lin X, Yan SZ, Qi SS, Xu Q, Han SS, Guo LY, et al. Transferrin-modified nanoparticles for photodynamic therapy enhance the antitumor efficacy of hypocrellin A. Front Pharmacol. 2017;8:1–16.
Jeong YI, Cha B, Lee HL, Song YH, Jung YH, Kwak TW, et al. Simple nanophotosensitizer fabrication using water-soluble chitosan for photodynamic therapy in gastrointestinal cancer cells. Int J Pharm. 2017;532:194–203.
Garcia MTJ, de Paula Freitas C, Graciano TB, Coutinho TS, Cressoni CB, de Lima Pereira SA, et al. Chitosan-based mucoadhesive gel for oral mucosal toluidine blue O delivery: the influence of a non-ionic surfactant. Photodiagn Photodyn Ther. 2017;20:48–54.
Wei PR, Kuthati Y, Kankala RK, Lee CH. Synthesis and characterization of chitosan-coated near-infrared (NIR) layered double hydroxide-indocyanine green nanocomposites for potential applications in photodynamic therapy. Int J Mol Sci. 2015;16:20943–68.
Ferreira DP, Conceição DS, Calhelha RC, Sousa T, Socoteanu R, Ferreira ICFR, et al. Porphyrin dye into biopolymeric chitosan films for localized photodynamic therapy of cancer. Carbohydr Polym. 2016;151:160–71.
Voon SH, Tiew SX, Kue CS, Lee HB, Kiew LV, Misran M, et al. Chitosan-coated poly(lactic-co-glycolic acid)-diiodinated boron-dipyrromethene nanoparticles improve tumor selectivity and stealth properties in photodynamic cancer therapy. J Biomed Nanotechnol. 2016;12:1431–52.
Ferreira DP, Conceição DS, Fernandes F, Sousa T, Calhelha RC, Ferreira IC, et al. Characterization of a Squaraine/Chitosan system for photodynamic therapy of cancer. J Phys Chem B. 2016;120:1212–20.
Jia HR, Jiang YW, Zhu YX, Li YH, Wang HY, Han X, et al. Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cellular influx for photodynamic cancer therapy. J Control Release. 2017;255:231–41.
Sun L, Jiang W, Zhang H, Guo Y, Chen W, Jin Y, et al. Photosensitizer-loaded multifunctional chitosan nanoparticles for simultaneous in situ imaging, highly efficient bacterial biofilm eradication, and tumor ablation. ACS Appl Mater Interfaces. 2018. https://doi.org/10.1021/acsami.8b19522.
Zhang X, Li L, Liu Q, Wang Y, Yang J, Qiu T, et al. Co-delivery of Rose Bengal and doxorubicin nanoparticles for combination photodynamic and chemo-therapy. J Biomed Nanotechnol. 2019;15:184–95.
Acknowledgments
We thank Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) by grants FAPESP #2018/23015-7 and FAPESP #2018/09088-1, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Programa de Apoio ao Desenvolvimento Científico (PADC).
Abbreviations
5-ALA, 5-aminolevulinic acid; aPDT, antimicrobial photodynamic therapy; AuNPs, gold nanoparticles; Ce6, chlorin e6; CFU/mL, colony forming units per milliliter; CS, Chitosan; DDS, drug delivery systems; ER, erythrosine; ICG, indocyanine green; MB, methylene blue; NAC, N-acetyl cysteine; NIPAAm, poly(N-isopropylacrylamide); NP(s), nanoparticle(s); PDI, photodynamic inactivation; PDT, photodynamic therapy; PGA, poly(glutamic acid); PS(s), photosensitizer(s); RB, Rose Bengal; RNS, reactive nitrogen species; ROS, reactive oxygen species; TBO, Toluidine blue O; TPP, tripolyphosphate; VM, vancomycin
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Calixto, G.M.F., de Annunzio, S.R., Victorelli, F.D. et al. Chitosan-Based Drug Delivery Systems for Optimization of Photodynamic Therapy: a Review. AAPS PharmSciTech 20, 253 (2019). https://doi.org/10.1208/s12249-019-1407-y
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DOI: https://doi.org/10.1208/s12249-019-1407-y