Abstract
An automated sample pretreatment of human blood plasma for liquid chromatographic determination of three antidepressant drugs, dibenzepine; a tricyclic antidepressant (TCA), reboxetine; a selective noradrenaline reuptake inhibitor (SNRI) and fluvoxamine; a selective serotonin reuptake inhibitor (SSRI), based on supported liquid membrane (SLM) for unsurpassed sample clean-up and analyte enrichment, has been developed. The chromatograms after enrichment of plasma blank and aqueous blank are virtually indistinguishable. The entire analytical procedure revealed good linearity and low detection limits of 5, 15 and 20 ng mL−1 for dibenzepine, reboxetine and fluvoxamine, respectively. No carry-over effects were noted. The repeatability of extraction at three concentrations in the range 40–150 ng mL−1 for the three drugs was between ca. 3% and 7% as relative standard deviation. The reproducibility relative standard deviation during three different days (replacing the membrane each day) was not significantly higher.
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Enlund AM, Westerlund D (2000) J Chromatogr A 895:17–25
Sutherland FCW, Badenhorst D, de Jader AD, Scanes T, Hundt HKL, Swart KJ, Hundt AF (2001) J Chromatogr A 914:45–51
Maya MT, Domingos CR, Guerreiro MT, Morais JA (2000) J Pharm Biomed Anal 23:989–996
Alvarez J, Bothua D, Collignon I, Advenier C, Varoquaux OS (1998) J Chromatogr B 707:175–180
Wong SHY, Kranzler HR, Dellafera S, Fernandes R (1994) Biomed Chromatogr 8:278–282
Pullen RH, Fatmi AA (1992) J Chromatogr B 574:101–107
Härtter S, Weigmann H, Hiemke C (2000) J Chromatogr B 740:135–140
Kristoffersen L, Bugge A, Lundanes E, Slordal L (1999) J Chromatogr B 734:229–246
Raggi MA, Mandrioli R, Casamenti G, Bugamelli F, Volterra V (1998) J Pharm Biomed Anal 18:193–199
Härtter S, Wetzel H, Hiemke C (1992) Clin Chem 38:2082–2086
Jinno K, Kawazoe M, Hayashida M (2000) Chromatographia 52:309–313
Saito Y, Kawazoe M, Jinno K, Hayashida M (2000) Analyst 125:807–809
Addison RS, Franklin ME, Hooper WD (1998) J Chromatogr B 716:153–160
Fontanille P, Jourdil N, Villier C, Bessard G (1997) J Chromatogr B 692:337–343
Eap CB, Gaillard N, Powell K, Baumann P (1996) J Chromatogr B 682:265–272
Ulrich S, Martens J (1997) J Chromatogr B 696:217–234
Namera A, Watanabe T, Yashiki M, Iwasaki Y, Kojima T (1998) J Anal Toxicol 22:396–400
Jinno K, Kawazoe M, Saito Y, Takeichi T, Hayashida M (2001) Electrophoresis 22:3785–3790
Raggi MA, Bugamelli F, Sabbioni C, Ferranti A, Fanali S, Volterra V (2002) J Pharm Biomed Anal 27:209–215
Hackett LP, Dusci LJ, Ilett KF (1998) Therapeutic Drug Monitoring 20:30–34
Banger M, Hermes B, Hartter S, Hiemke C (1997) Pharmacopsychiatry 30:128–132
Poklis A, Edinboro LE, Lee JS, Crooks CR (1997) J Toxicol Clin Toxicol 35:77–82
Audunsson GA (1986) Anal Chem 58:2714
van de Merbel NC (1999) J Chromatogr A 856:55–82
Jönsson JÅ, Mathiassion L (2000) J Chromatogr A 902:205–225
Jönsson JÅ, Mathiasson L (2001) J Separation Sci 24:495–507
Jönsson JÅ (2003) Chromatographia Supplement 57:S317–S324
Lindegård B, Björk H, Jönsson JÅ, Mathiasson L (1994) Anal Chem 66:4490–4497
Jönsson JÅ, Andersson M, Melander C, Norberg J, Thordarson E, Mathiasson L (2000) J Chromatogr A 870:151–157
Pálmarsdóttir S, Thordarson E, Edholm L-E, Jönsson JÅ, Mathiasson L (1997) Anal Chem 69:1732–1737
Fleishaker JC (2000) Clin Pharmacokinetics 39:413–427
Fleishaker JC (2000) Rev Contemp Pharmacotherapy 11:283–293
van Harten J (1995) Clin Pharmacokinetics 29 Suppl 1:1–9
Shen Y, Grönberg L, Jönsson JÅ (1994) Anal Chim Acta 292:31–39
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Barri, T., Jönsson, J. Supported Liquid Membrane Work-Up of Blood Plasma Samples Coupled On-Line to Liquid Chromatographic Determination of Basic Antidepressant Drugs. Chromatographia 59, 161–165 (2004). https://doi.org/10.1365/s10337-003-0147-y
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DOI: https://doi.org/10.1365/s10337-003-0147-y