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Plasmalemmal vacuolar-type H+-ATPase in cancer biology

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Abstract

Vacuolar-type H+-adenosine triphosphatase (V-ATPase) is one of the most fundamental enzymes in nature. V-ATPases are responsible for the regulation of proton concentration in the intracellular acidic compartments. It has similar structure with the mitochondrial F0F1-ATP synthase (F-ATPase).† The V-ATPases are composed of multiple subunits and have various physiological functions, including membrane and organelle protein sorting, neurotransmitter uptake, cellular degradative processes, and cytosolic pH regulation. The V-ATPases have been involved in multidrug resistance. Recently, plasma membrane V-ATPases have been involved in regulation of extracellular acidity, essential for cellular invasiveness and proliferation in tumor metastasis. The current knowledge regarding the structure and function of V-ATPase and its role in cancer biology is discussed.

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  1. Department of Physiology, Texas Tech University, Health Sciences Center, 79430, Lubbock, TX

    Souad R. Sennoune, Defeng Luo & Raul Martinez-Zaguilán

  2. Southwest Cancer Center, Texas Tech University, Health Sciences Center, 79430, Lubbock, TX

    Raul Martinez-Zaguilán

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  1. Souad R. Sennoune
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F in F0F1 ATPase is the coupling energy factor.

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Sennoune, S.R., Luo, D. & Martinez-Zaguilán, R. Plasmalemmal vacuolar-type H+-ATPase in cancer biology. Cell Biochem Biophys 40, 185–206 (2004). https://doi.org/10.1385/CBB:40:2:185

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