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Identifying protein interactors in gonadotropin action

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Abstract

Systems biology integrates a variety of diverse approaches to the study of the cellular pathways comprised of protein networks. Following an initial ligand-receptor binding event, transduction of the signal is modified in a variety of ways via downstream protein interactions. Protein interactions can occur between two proteins or, alternatively, an interaction between two proteins can be facilitated by an adapter protein. Protein interactions can affect the spatial and temporal distribution of ligand-receptor complexes in cells, attenuating or prolonging signaling. With regard to gonadotropin receptors, protein interactions have been primarily studied in terms of desensitization and termination of signal transduction, or for their role in trafficking. The purpose of this review is to describe protein interactions that mediate gonadotropin receptor functions and to highlight some emerging interactions, as well as some of the caveats inherent in the attempt to uncover these pathways.

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Authors and Affiliations

  1. Department of Biomedical Sciences, State University of New York at Albany, Albany, NY

    James A. Dias PhD

  2. New York State Department of Health, Wadsworth Center, David Axelrod Institute for Public Health, 120 New Scotland Avenue, 12208, Albany, New York

    James A. Dias PhD, Cheryl A. Nechamen & Raghad Atari

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  1. James A. Dias PhD
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  2. Cheryl A. Nechamen
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  3. Raghad Atari
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Correspondence to James A. Dias PhD.

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Dias, J.A., Nechamen, C.A. & Atari, R. Identifying protein interactors in gonadotropin action. Endocr 26, 241–247 (2005). https://doi.org/10.1385/ENDO:26:3:241

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  • DOI: https://doi.org/10.1385/ENDO:26:3:241

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