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Interleukin-8 and its receptor CXCR2 in atherosclerosis

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Abstract

The participation of inflammatory cells in atherosc lerosis is a well-known process that involves numerous molecules including chemotactic cytokines (chemokines) for their entry into the vessel wall. Although the C-C chemokine monocyte chemoattractant protein-1 and its receptor, CCR2, have been implicated in atherosclerosis, the role of the classic C-X-C chemokine, interleukin-8 (KC/growth-related oncogene α in mice) and its receptor XCCR2 has not been studied in the pathogenesis of atherosclerosis. Our research has shown that CXC R2 is strongly expressed on macrophages (Mф) in atherosclerotic lesion. This CXCR2 expression is proatherogenic in that CXCR2 deficiency significantly reduces the progression of advanced atherosclerosis in mice. Although the mechanism still needs to be worked out, it appears that CXCR2 expression on lesion Mф is essential for these cells to be retained in the lesion.

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  1. William A. Boisvert

    Present address: Department of Immunology, The Scrippes Research Institute, 10550 N. Toney Pines Road, 92037, La Joln, CA

Authors and Affiliations

  1. Department of Immunology, The Scrippes Research Institute, 10550 N. Toney Pines Road, 92037, La Joln, CA

    Linda K. Curnss

  2. Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA

    Linda K. Curnss

  3. Department of Medicine VA Medical Center, University of California, San Diego, CA

    Robert A. Terkeltaub

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Boisvert, W.A., Curnss, L.K. & Terkeltaub, R.A. Interleukin-8 and its receptor CXCR2 in atherosclerosis. Immunol Res 21, 129–137 (2000). https://doi.org/10.1385/IR:21:2-3:129

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