Abstract
Major advances in the identification of genes expressed in malformation-associated epileptic disorders have been made. Some of these changes reflect the complex gene interactions necessary for proper neurodevelopment, whereas others suggest specific synaptic aberrations that could result in a hyperexcitable, and ultimately, epileptic condition. Here we review reported changes in gene expression associated with a malformed brain, with particular emphasis on how these changes provide clues to seizure genesis.
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Paredes, M.F., Baraban, S.C. A review of gene expression patterns in the malformed brain. Mol Neurobiol 26, 109–116 (2002). https://doi.org/10.1385/MN:26:1:109
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DOI: https://doi.org/10.1385/MN:26:1:109