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Polyphenols in cerebral ischemia

Novel targets for neuroprotection

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Abstract

Plant polyphenols are dietary components that exert a variety of biochemical and pharmacological effects. Recently, considerable interest has been focused on polyphenols because of their antioxidant, anti-inflammatory, and antiproliferative activities. Oxidative stress is thought to be a key event in the pathogenesis of cerebral ischemia. Overproduction of reactive oxygen species during ischemia/reperfusion could cause an imbalance between oxidative and antioxidative processes. Reactive oxygen species can damage lipids, proteins, and nucleic acids, thereby inducing apoptosis or necrosis. There is increasing evidence supporting the hypothesis that plant polyphenols can provide protection against neurodegenerative changes associated with cerebral ischemia. This article reviews the neuroprotective effects of plant extracts and their constituents that have been used in animal models of cerebral ischemia. The use of polyphenols as therapeutic agents in stroke has been suggested.

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Authors and Affiliations

  1. Department of Biochemistry and Pathology, University of Missouri-Columbia, Columbia, MO

    Agnes Simonyi, Phullara B. Shelat & Grace Y. Sun

  2. Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, MO

    Qun Wang, Rebecca L. Miller, Mozow Yusof & Albert Y. Sun

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  1. Agnes Simonyi
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  2. Qun Wang
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Correspondence to Agnes Simonyi.

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Simonyi, A., Wang, Q., Miller, R.L. et al. Polyphenols in cerebral ischemia. Mol Neurobiol 31, 135–147 (2005). https://doi.org/10.1385/MN:31:1-3:135

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