Skip to main content
SpringerLink
Log in

A Reappraisal of Quinolone Tolerability

The Experience of their Musculoskeletal Adverse Effects

  • Leading Article
  • Published:
Drug Safety Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Williams JD. Quo vadis with bacterial resistance? Drugs 1995; 49 Suppl. 2: 1–9

    Article  PubMed  Google Scholar 

  2. Ball P, Tillotson G. Tolerability of fluoroquinolone antibiotics: past, present and future. Drug Saf 1995 Dec; 13(6): 343–58

    Article  PubMed  CAS  Google Scholar 

  3. Blum MD, Graham DJ, McCloskey CA. Temafloxacin syndrome: review of 95 cases. Clin Infect Dis 1994; 18: 946–50

    Article  PubMed  CAS  Google Scholar 

  4. Rubinstein E. Tolerance of sparfloxacin. Sparfloxacin Symposium. Rhone Poulenc Rorer; 1995 Jun 24–25; Seville

    Google Scholar 

  5. Huston KA. Achilles tendinitis and tendon rupture due to fluoroquinolone antibiotics. N Engl J Med 1994; 331: 748

    Article  PubMed  CAS  Google Scholar 

  6. Lee WT, Collins JF. Ciprofloxacin associated bilateral tendon rupture. Aust NZ J Med 1992; 22: 500

    CAS  Google Scholar 

  7. MacEwan SR, Davey PG. Ciprofloxacin and tenosynovitis. Lancet 1988; ii: 900

    Article  Google Scholar 

  8. Ribard P, Audisio F, Kahn MF, et al. Seven Achilles tendonitis including 3 complicated by rupture during fluoroquinolone therapy. J Rheumatol 1992; 19: 1479–81

    PubMed  CAS  Google Scholar 

  9. Szarfman A, Chen M, Blum MD. More on fluoroquinolone antibiotics and tendon rupture [letter]. N Engl J Med 1995; 332: 193

    Article  PubMed  CAS  Google Scholar 

  10. Schaad U, Salam MA, Aujard Y, et al. Use of fluoroquinolones in pediatrics: consensus report of an International Society of Chemotherapy Commission. Pediatr Infect Dis J 1995; 14: 1–9

    Article  PubMed  CAS  Google Scholar 

  11. Chysky V, Kapila K, Jullman G, et al. Safety of ciprofloxacin in children: worldwide clinical experience based on compassionate use: emphasis on joint evaluation. Infection 1991; 19: 289–96

    Article  PubMed  CAS  Google Scholar 

  12. Pradhan KM, Arora NK, Jena A, et al. Safety of ciprofloxacin therapy in children: magnetic resonance images, body fluid levels of fluoride and linear growth. Acta Paediatr 1995; 84: 555–60

    Article  PubMed  CAS  Google Scholar 

  13. Schaad UB, Sander E, Wedgwood J, et al. Morphologic studies for skeletal toxicity after prolonged ciprofloxacin therapy in two juvenile cystic fibrosis patients. Pediatr Infect Dis J 1992; 11: 1047–9

    Article  PubMed  CAS  Google Scholar 

  14. Bouissou H, Caujolle D, Caujolle F, et al. Toxicologie experimentale. Tissus cartilagineux et acide nalidixique. C R Acad Sci Hebd Seances Acad Sci D 1978; 286: 1743–6

    PubMed  CAS  Google Scholar 

  15. Gough A, Barsoum NJ, Mitchell L, et al. Juvenile canine druginduced arthropathy: clinicopathological studies on articular lesions caused by oxolinic and pipemidic acids. Toxicol Appl Pharmacol 1979; 51: 177–87

    Article  PubMed  CAS  Google Scholar 

  16. Ingham B, Brentnall DW, Dale EA, et al. Arthropathy induced by antibacterial fused N-alkyl-4-pyridone-3-carboxylic acids. Toxicol Lett 1977; 1: 21–6

    Article  CAS  Google Scholar 

  17. McDonald DF, Short HB. Usefulness of nalidixic acid in treatment of urinary infection. Antimicrob Agents Chemother 1964; 4: 628–31

    Google Scholar 

  18. Ribard P, Kahn MF. Rheumatological side-effects of quinolones. In: Kahn MF, editor. Baillière’s clinical rheumatology: drug-induced rheumatic diseases. London: Baillière Tindall, 1991: 175–91

    Google Scholar 

  19. Chevalier X, Albengres E, Voisin MC, et al. A case of destructive polyarthropathy in a 17-year-old youth following pefloxacin treatment. Drug Saf 1992; 7: 310–4

    Article  PubMed  CAS  Google Scholar 

  20. Pertuiset E, Lenoir G, Jehanne M, et al. Tolérance articulaire de la péfloxacine et de l’ofloxacine chez les enfants et adolescents atteints de mucoviscidose. Rev Rhum Mal Osteoartic 1989; 56: 735–40

    PubMed  CAS  Google Scholar 

  21. Schaad UB, Stoupis C, Wedgwood J, et al. et al. Clinical, radiologic and magnetic resonance monitoring for skeletal toxicity in pediatric patients with cystic fibrosis receiving a three-month course of ciprofloxacin. Pediatr Infect Dis J 1991; 10: 723–9

    PubMed  CAS  Google Scholar 

  22. Tatsumi H, Senda H, Yatera S, et al. Toxicological studies on pipemidic acid. V. Effect on diarthrodial joints of experimental animals. J Toxicol Sci 1978; 3: 357–67

    Article  PubMed  CAS  Google Scholar 

  23. Burkhardt JE, Hill MA, Turek JJ, et al. Ultrastructural changes in articular cartilages of immature beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathol 1992; 29: 230–8

    Article  PubMed  CAS  Google Scholar 

  24. Stahlmann R, Merker HJ, Hinz N, et al. Ofloxacin in juvenile non-human primates and rats. Arthropathia and drug plasma concentrations. Arch Toxicol 1990; 64: 193–204

    Article  PubMed  CAS  Google Scholar 

  25. Burkhardt JE, Hill MA, Carlton WW, et al. Histologic and histochemical changes in articular cartilages of immature beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathol 1990; 27: 162–70

    Article  PubMed  CAS  Google Scholar 

  26. Machida M, Kusajima H, Aijima H, et al. Toxokinetic study of norfloxacin-induced arthropathy in juvenile animals. Toxicol Appl Pharmacol 1990; 105: 403–12

    Article  PubMed  CAS  Google Scholar 

  27. Hayem G, Petit PX, Levacher M, et al. Cytofluorometric analysis of chondrotoxicity of fluoroquinolone antimicrobial agents. Antimicrob Agents Chemother 1994; 38: 243–7

    Article  PubMed  CAS  Google Scholar 

  28. Thuong-Guyot M, Domarle O, Pocidalo JJ, et al. Effects of fluoroquinolones on cultured articular chondrocytes. Flow cytometric analysis of free radical production. J Pharmacol Exp Ther 1994; 271: 1544–9

    PubMed  CAS  Google Scholar 

  29. Bendele AM, Hulman JF, Harvey AK, et al. Passive role of articular chondrocytes in quinolone-induced arthropathy in guinea pigs. Toxicol Pathol 1990; 18: 304–12

    Article  PubMed  CAS  Google Scholar 

  30. Stahlmann R, Förster C, Shakibaei M, et al. Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone induced arthropathy. Antimicrob Agents Chemother 1995; 39: 2013–8

    Article  PubMed  CAS  Google Scholar 

  31. Perrot S, Ziza JM, De Bourran-Cauet G, et al. Nouvelle complication liée aux quinolones: la rupture du tendon d’Achille. Presse Med 1991; 20: 1234

    PubMed  CAS  Google Scholar 

  32. Kato M, Takeda S, Kashida Y, et al. Histological examination of Achilles tendon lesions induced by quinolone antibacterial agents in juvenile rats. Toxicol Path 1995; 23: 385–92

    Article  CAS  Google Scholar 

  33. Bailey RR, Kirk JA, Peddie B A. Norfloxacin induced rheumatic disease. NZ Med J 1983; 96: 590

    CAS  Google Scholar 

  34. Bailey RR, Peddie BA. Enoxacin for the treatment of urinary tract infection. NZ Med J 1985; 98: 286–8

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinique de Rhumatologie, CHU Bichat-Claude Bernard, Paris, France

    Gilles Hayem

  2. Service de Médecine Interne, CHU Bichat-Claude Bernard, Paris, France

    Claude Carbon

  3. INSERM U 13, CHU Bichat-Claude Bernard, Paris, France

    Gilles Hayem & Claude Carbon

Authors
  1. Gilles Hayem
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Claude Carbon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hayem, G., Carbon, C. A Reappraisal of Quinolone Tolerability. Drug-Safety 13, 338–342 (1995). https://doi.org/10.2165/00002018-199513060-00003

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00002018-199513060-00003

Keywords

Search

Navigation