Summary
The efficacy, tolerance and effect on serum lipids of acebutolol were compared with those of atenolol over a 6- month period in a large group of patients with mild arterial hypertension.
Both drugs were equally effective in reducing blood pressure, and tolerance was generally excellent. High density lipoprotein (HDL)-cholesterol concentrations were reduced to a similar extent by both treatments at 2 months and this change was reflected in measurements of the total cholesterol concentrations. However, no significant changes occurred in serum triglyceride levels and at 6 months all serum lipid parameters had returned to baseline values.
These observations suggest that cardioselective β-blockers have no adverse effects on serum lipids at 6 months, after a temporary reduction of HDL-cholesterol at 2 months.
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References
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De Backer, G. Multicentre Study of the Efficacy and Tolerance of Acebutolol versus Atenolol in the Long Term Treatment of Mild Arterial Hypertension. Drugs 36 (Suppl 2), 51–56 (1988). https://doi.org/10.2165/00003495-198800362-00009
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DOI: https://doi.org/10.2165/00003495-198800362-00009