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Health State Preference Assessment in Diabetic Peripheral Neuropathy

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Abstract

Objective: To assess patient preferences for health states associated with diabetic peripheral neuropathy (DPN).

Design and intervention: Seven health states describing varying stages of disease severity in DPN were developed: mild neuropathy, painful neuropathy, severe neuropathy, minor ulcer, severe ulcer, minor amputation and major amputation. Using a computer interview, both rating scale (RS) and standard gamble (SG) preference scores were elicited from 52 patients with diabetes mellitus.

Setting: A US university medical centre and a Veterans Affairs clinic.

Study participants: Adult patients with type 1 and type 2 diabetes mellitus between the ages of 18 and 80 years. Patients were excluded if they had been diagnosed with DPN.

Results: Preference scores decreased in accordance with greater symptomatic and functional impairment. Median RS scores ranged from 0.89 to 0.23 for the seven health states. Median SG scores ranged from 0.96 to 0.65.

Conclusions: Patient preferences for health states decrease as a function of increasing disease severity in DPN. The result is robust across the RS and SG methods of preference measurement. These results may be useful in informing policy analyses for resource allocation in patients with diabetes mellitus.

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Acknowledgements

The authors wish to acknowledge Darren Augenstein and Louis Garrison, Jr. for their help in the design and analysis of the study. Financial support for this study was provided in part by a contract from Roche Pharmaceuticals. The funding agreement ensured the authors’ independence in designing the study, interpreting the data, writing and publishing the report. At the time of the study, the following authors were completing a post-doctoral fellowship sponsored by Roche and administered by the University of Washington: Doris P. Lew, E. Beth Devine and David L. Veenstra.

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Authors and Affiliations

  1. Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Box 357630, Seattle, Washington, 98195-7630, USA

    Sean D. Sullivan, Doris P. Lew, E. Beth Devine & David L. Veenstra

  2. Department of Health Services, University of Washington, Seattle, Washington, USA

    Sean D. Sullivan & Gayle E. Reiber

  3. Kaiser Permanente Drug Information and Professional Services, Oakland, California, USA

    Doris P. Lew

  4. Roche Pharmaceuticals - Health Economics and Strategic Pricing, Nutley, New Jersey, USA

    Zafar Hakim

  5. Department of Epidemiology, University of Washington, Seattle, Washington, USA

    Gayle E. Reiber

  6. Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA

    Gayle E. Reiber

Authors
  1. Sean D. Sullivan
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  2. Doris P. Lew
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  3. E. Beth Devine
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  4. Zafar Hakim
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  5. Gayle E. Reiber
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  6. David L. Veenstra
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Correspondence to Sean D. Sullivan.

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Sullivan, S.D., Lew, D.P., Devine, E.B. et al. Health State Preference Assessment in Diabetic Peripheral Neuropathy. Pharmacoeconomics 20, 1079–1089 (2002). https://doi.org/10.2165/00019053-200220150-00004

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  • DOI: https://doi.org/10.2165/00019053-200220150-00004

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