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Effective microorganism substance (EM-S) reduces development and aggravation of atopic dermatitis-like skin lesions in NC/Nga mice

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Abstract

In a previous study, our group showed that the effective microorganism substance (EM-S) produced by fermentation of medicinal plants with effective microorganisms has an antiinflammatory effect on atopic dermatitis-like lesions in NC/Nga mice. However, the possible antiinflammatory effect and skin barrier function of EM-S for inflammatory cell infiltration, Interleukin-4 (IL-4) production, C-C chemokine receptor 10 (CCR10), and filaggrin (FLG) expression were not reported. Therefore, effects of EM-S on the development of atopic dermatitislike skin lesions in NC/Nga mice were evaluated. Efficacy of EM-S was judged by measurement of scratching behavior, T-cell subset infiltration, cytokine production, and FLG expression. Topical application of EM-S significantly reduced scratching behavior in NC/Nga mice caused by house dust mite antigen (Dermatophagoides farinse extract, DfE) sensitization. IL-4 production and CD4+ and CD45+ cell infiltrations were significantly reduced by EM-S. CCR10 expression was also significantly inhibited by EM-S. EM-S treatment also increased the level of FLG reduced by DfE sensitization. These results demonstrate EM-S, when applied topically, may be an effective substance for management of atopic dermatitis patients.

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Authors and Affiliations

  1. Department of Biochemistry, Chonbuk National University Medical School, 561-756, Jeonju, Republic of Korea

    Kwang-Hyun Park

  2. Jeonju Biomaterials Institute, 561-360, Jeonju, Republic of Korea

    Seung-II Jeong

  3. Jeonju University Atopy & Health Research Institute, 560-759, Jeonju, Republic of Korea

    Ji Ye Mok & and Seon Il Jang

  4. School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University, 560-759, Jeonju, Republic of Korea

    Jung-Keun Cho, Ji Min Park, In Hwa Jeon, Hyeon Soo Kim & and Seon Il Jang

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  1. Kwang-Hyun Park
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  2. Seung-II Jeong
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  3. Ji Ye Mok
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  4. Jung-Keun Cho
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  5. Ji Min Park
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  6. In Hwa Jeon
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  8. and Seon Il Jang
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Correspondence to and Seon Il Jang.

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Park, KH., Jeong, SI., Mok, J.Y. et al. Effective microorganism substance (EM-S) reduces development and aggravation of atopic dermatitis-like skin lesions in NC/Nga mice. J. Korean Soc. Appl. Biol. Chem. 54, 211–220 (2011). https://doi.org/10.3839/jksabc.2011.035

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  • DOI: https://doi.org/10.3839/jksabc.2011.035

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