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The Somatotrophic Axis and the Reproductive Process in Health and Disease

  • Conference proceedings
  • © 1995

Overview

Editors:
  1. Eli Y. Adashi

    1. Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, USA

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  2. Michael O. Thorner

    1. Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Serono Symposia USA (SERONOSYMP)

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Table of contents (24 papers)

  1. Front Matter

    Pages i-xviii
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  2. Growth Hormone and Its Receptor: State of the Art

    1. Front Matter

      Pages 1-1
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    2. Growth Hormone: A Current Perspective

      • M. O. Thorner, M. L. Hartman, C. M. Silva, B. D. Gaylinn, J. A. Aloi, S. E. Kirk et al.
      Pages 3-13

    3. Probing and Designing Growth Hormone-Receptor Interactions

      • James A. Wells, Anthony A. Kossiakoff
      Pages 14-22

    4. Human Growth Hormone Binding Proteins: Regulation and Physiological Significance

      • Gerhard Baumann, Moises Mercado, Norma Davila, Melissa Shaw, Klaus Amburn
      Pages 23-27

    5. Ovarian Prolactin Receptors and Their Placental Ligands

      • Daniel I. H. Linzer, Brian J. Arey
      Pages 28-39

    6. Regulatory Actions of Testosterone on Pulsatile Growth Hormone Secretion in the Human: Studies Using Deconvolution Analysis

      • J. D. Veldhuis, A. Iranmanesh, A. D. Rogol, R. J. Urban
      Pages 40-57

    7. Growth Hormone and IGF-I as Anabolic Partitioning Hormones

      • David R. Clemmons
      Pages 58-65

  3. Pubertal, Menstrual, Gestational, and Menopausal Adaptation

    1. Front Matter

      Pages 67-67
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    2. Growth Hormone Secretory Dynamics During Puberty

      • Alan D. Rogol, Paul M. Martha Jr., Michael Johnson, Johannes D. Veldhuis, Robert M. Blizzard
      Pages 69-82

    3. Impact of Growth Hormone on the Timing and Progression of Puberty: How Are Growth and Sexual Maturation Linked?

      • Paul A. Boepple
      Pages 83-93

    4. Role of Growth Hormone in the Promotion of Linear Skeletal Growth

      • Claes Ohlsson, Jörgen Isgaard, Anders Lindahl, Olle G. P. Isaksson
      Pages 94-106

    5. Growth Hormone Economy in Normally Cycling Women

      • W. S. Evans, R. A. Booth Jr., K. K. Y. Ho, A. C. S. Faria, C. M. Asplin, J. D. Veldhuis et al.
      Pages 107-123

    6. Gestational Physiology of the Growth Hormone Gene Family

      • Nancy E. Cooke, Beverly K. Jones, Alan Salzman, J. Eric Russell, Anita Misra-Press, Margrit Urbanek et al.
      Pages 124-141

    7. Growth Hormone Economy in Menopausal Women: Effects of Age

      • Mark L. Hartman, Jill A. Kanaley, Arthur Weltman
      Pages 142-159

    8. Growth Hormone Economy in Hypogonadism: Effects of Sex Steroids

      • Ken K. Y. Ho, Andrew J. Weissberger, John J. Kelly
      Pages 160-171

  4. Growth Hormone: The Ovarian Connection

    1. Front Matter

      Pages 173-173
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    2. Ovary as a Site of Growth Hormone Reception and Action

      • Eli Y. Adashi
      Pages 175-182

    3. Ovarian IGF System: Interface with the Gonadotropic and Somatotrophic Axes

      • James M. Hammond, Susan Samaras, Randall Grimes, Daniel Hagen, David Guthrie
      Pages 183-201

    4. Is the Intraovarian IGF System a Mediator of Growth Hormone Action?

      • J. K. Findlay
      Pages 202-211
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Keywords

About this book

For many years now, our understanding of the somatotrophic and reproduc­ tive axes has evolved essentially independently, both fields of study reaching a highly advanced, although far from complete, level of under­ standing. Along the way, however, it became apparent that in some circumstances the reproductive and somatotrophic axes may be inter­ dependent. Inklings to this effect were at times feeble and at other times more convincing. Among those inklings are the clinical recognition by pediatric endocrinologists of the apparent association between isolated GH deficiency and delayed puberty, as well as of the apparent permissive, pUberty-promoting property of GH. Equally important is a body of experi­ mental studies establishing the ovary of multiple species as a site of GH reception and action. Arguing against an essential role for GH in the reproductive process is the observation that individuals who have GH resistance of the Laron variety are fertile arid that isolated GH deficiency does not constitute an absolute barrier to the attainment of sexual maturation and fertility. The intraovarian insulin-like growth factor (IGF) hypothesis proposes that IGFs may serve as amplifiers of gonadotropin action. Although the dependence of intraovarian IGFs on systemic GH action has never been unequivocally demonstrated, that leap of faith has often been made. The intraovarian IGF hypothesis serves as the rationale for the adjunctive use of GH in the induction of ovulation.

Editors and Affiliations

  • Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, USA

    Eli Y. Adashi

  • Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA

    Michael O. Thorner

Bibliographic Information

  • Book Title: The Somatotrophic Axis and the Reproductive Process in Health and Disease

  • Editors: Eli Y. Adashi, Michael O. Thorner

  • Series Title: Serono Symposia USA

  • DOI: https://doi.org/10.1007/978-1-4612-2518-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York, Inc. 1995

  • Hardcover ISBN: 978-0-387-94419-7Due: 23 June 1995

  • Softcover ISBN: 978-1-4612-7567-1Published: 27 September 2011

  • eBook ISBN: 978-1-4612-2518-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 332

  • Topics: Endocrinology, Gynecology, Human Physiology, Cell Biology

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