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Relaxing and Contracting Factors

Biological and Clinical Research

  • Book
  • © 1988

Overview

Editors:
  1. Paul M. Vanhoutte

    1. Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, USA

    View editor publications

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Part of the book series: The Endothelium (TEEN)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xxv
    Download chapter PDF

  2. Endothelium-Dependent Relaxation in Systemic Arteries

    • Robert F. Furchgott
    Pages 1-26

  3. Endothelium-Dependent Contractions in Veins and Arteries

    • Paul M. Vanhoutte
    Pages 27-39

  4. The Nature of Endothelium-Derived Relaxing Factor

    • T. M. Griffith, A. H. Henderson
    Pages 41-64

  5. Metabolism of Arachidonic Acid and Release of Endothelium-Derived Relaxing Factors

    • Roger A. Johns, Michael J. Peach
    Pages 65-89

  6. Modulation of the Release and Biological Activity of Endothelium-Derived Relaxing Factor by Oxygen-Derived Free Radicals

    • Gabor M. Rubanyi, Paul M. Vanhoutte
    Pages 91-105

  7. Endothelial Cells in Culture and Production of Endothelium-Derived Relaxing Factor

    • T. M. Cocks, J. A. Angus, J. H. Campbell, G. R. Campbell
    Pages 107-135

  8. Endothelial Cells in Culture and Production of Endothelium-Derived Constricting Factors

    • Robert F. Highsmith, David Aichholz, Oliver FitzGerald, Richard Paul, Gabor M. Rubanyi, Kristine Hickey
    Pages 137-158

  9. Basal Release of Endothelium-Derived Relaxing Factor

    • William Martin
    Pages 159-178

  10. Calcium Transport Mechanisms in Endothelial Cells Regulating the Synthesis and Release of Endothelium-Derived Relaxing Factor

    • Gabor M. Rubanyi, Arnold Schwartz, Paul M. Vanhoutte
    Pages 179-188

  11. Release of Endothelium-Derived Relaxing Factor(s) by Physicochemical Stimuli

    • Eberhard Bassenge, Rudi Busse, Ulrich Pohl
    Pages 189-217

  12. Role of Cyclic GMP in Endothelium-Dependent Relaxation of Vascular Smooth Muscle

    • Robert M. Rapoport, Ferid Murad
    Pages 219-239

  13. Modulation by the Endothelium of Agonist-Induced Contractions of Vascular Smooth Muscle

    • R. C. Miller, V. Schini, P. Schoeffter
    Pages 241-265

  14. Endothelium-Derived Relaxing Factor Relaxes Vascular Smooth Muscle by Cyclic GMP-Mediated Effects on Calcium Movements

    • P. Collins, M. J. Lewis, A. H. Henderson
    Pages 267-283

  15. Heterogeneity in Endothelium-Dependent Relaxations Acute, Chronic, and Evolutionary Modulations

    • Virginia M. Miller, Paul M. Vanhoutte
    Pages 285-307

  16. Endothelium-Dependent Regulation of Resting Levels of Cyclic GMP and Cyclic AMP and Tension in Pulmonary Arteries and Veins

    • Louis J. Ignarro, Russell E. Byrns, Keith S. Wood
    Pages 309-332

  17. Endothelium-Dependent Reponses of Cerebral Arteries

    • Z. S. Katusic, J. T. Shepherd
    Pages 333-345

  18. Endothelium, Blood Flow, and Vascular Responses in Large Coronary and Iliac Arteries of the Conscious Dog

    • Mark A. Young, Stephen F. Vatner
    Pages 347-360

  19. Endothelium-Dependent Responses in Large Arteries and in the Microcirculation

    • J. A. Angus, T. M. Cocks, C. E. Wright, K. Satoh, G. R. Campbell
    Pages 361-387

  20. Endothelium-Dependent Responses in the Peripheral Microcirculation

    • T. M. Griffith, D. H. Edwards, R. L. Davies, T. J. Harrison, K. T. Evans
    Pages 389-416
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Keywords

About this book

It is an exciting task to be the editor of the first monograph covering a new area of the biomedical sciences. Since the first report in 1980 by Robert Furchgott and colleagues (see Chapter 1) of the evidence of endothelium-dependent relaxation in isolated arteries, there are ever­ increasing numbers of vascular physiologists and pharmacologists who are scraping away the endothelium to look into its role in cardiovascular con­ trol. And the more one looks, the more one discovers. Not only is the list of substances that can induce endothelium-dependent relaxations im­ pressively long, but these intriguing cells can also secrete vasoconstrictor substances. The ability of the endothelium to modulate the degree of con­ traction of the underlying smooth muscle is an ancestral property of the blood vessel wall, illustrating the logic of nature, since the endothelial cells are located in the best possible strategic location to continuously monitor the properties (chemical or physical) of the blood. And more and more data emerge suggesting that in several cardiovascular diseases per­ turbations in endothelium-dependent responses are one of the early signs of the abnormal process. Thus, the importance of endothelium-dependent responses, triggered by the intellectual curiosity of one of the pioneers of vascular physiology and pharmacology, is now recognized not only by basic scientists, but also by all concerned with the cardiovascular diseases. The purpose of this monograph is to provide them with a reference work, so that they know where to start.

Editors and Affiliations

  • Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, USA

    Paul M. Vanhoutte

Bibliographic Information

  • Book Title: Relaxing and Contracting Factors

  • Book Subtitle: Biological and Clinical Research

  • Editors: Paul M. Vanhoutte

  • Series Title: The Endothelium

  • DOI: https://doi.org/10.1007/978-1-4612-4588-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Humana Press Inc. 1988

  • Hardcover ISBN: 978-0-89603-128-9Published: 24 August 1988

  • Softcover ISBN: 978-1-4612-8939-5Published: 22 January 2012

  • eBook ISBN: 978-1-4612-4588-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXVI, 544

  • Topics: Human Physiology

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