Overview
- Editors:
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Marc Feldmann
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Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College London, London, UK
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Jonathan R. Lamb
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MRC Tuberculosis and Related Infections, Hammersmith Hosptial, London, UK
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James N. Woody
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Tissue Bank, Naval Medical Research Institute, Bethesda, USA
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Table of contents (40 chapters)
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T Cell Receptor
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- Oreste Acuto, Marina Fabbi, Ellis L. Reinherz
Pages 3-14
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- Kathryn Haskins, Neal Roehm, Charles Hannum, Janice White, Ralph Kubo, Philippa Marrack et al.
Pages 15-23
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- Nicholas R. J. Gascoigne, Yueh-hsiu Chien, Phillip Patten, Daniel M. Becker, Tullia Lindsten, Joshua Kavaler et al.
Pages 25-34
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- Mary K. L. Collins, A. Maija Kissonerghis, M. Jenny Dunne, Michael J. Owen
Pages 35-46
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HLA Antigens and Their Recognition
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- John Trowsdale, Penelope Austin, Susan Carson, Adrian Kelly, Jonathan Lamb, John Young
Pages 49-57
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- William E. Biddison, Stephen Shaw
Pages 59-69
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- Erik Qvigstad, Erik Thorsby
Pages 83-90
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- T. Sasazuki, Y. Nishimura, K. Tsukamoto, K. Hirayama, T. Sone
Pages 91-103
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- Lesley E. Wallace, Melanie A. Houghton, Alan B. Rickinson
Pages 105-114
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Clones Recognizing Extrinsic Antigens
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Front Matter
Pages 115-116
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- J. R. Lamb, M. Feldmann, N. Green, R. A. Lerner, E. D. Zanders
Pages 117-124
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- David J. Volkman, Thomas B. Nutman, Eric A. Ottesen, Anthony S. Fauci
Pages 125-133
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- Ann D. M. Rees, Glenda L. Knott, Paul N. Nelson, Nicola Dobson, Ruth Mathews, Peter W. Andrew
Pages 135-145
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- F. Sinigaglia, D. Scheidegger, A. Lanzavecchia, M. Pletscher, R. J. Scheper, G. Garotta
Pages 163-170
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Role of Cell Surface Molecules in T Cell Function
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Front Matter
Pages 171-172
About this book
Most complex biological systems, such as enzyme pathways, are effec tively controlled near the beginning of the process. There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav ing a paramount influence on the ensuing events. Thus, analysis of the early stages of the immune responses has been a preoccupation of many immunologists. This has been considerably aided by the capac ity to expand these early events, and 'immortalize' them as clones of T cells, for detailed analysis. The discovery by Morgan, Ruscetti, and Gallo (Science 193, 1007, 1976) of T-cell growth factor (now termed interleukin-2 or IL-2) has had a major impact in immunology that is far from over. The greater ease of handling murine tissues experimentally, with the availability of more precisely defined reagents such as inbred strains, has meant that, to date, most of the work on long-term T-cell cultures has been per formed in the mouse, as summarized by Fathman and Fitch (eds. , Iso lation, Characterization and Utilization of T Lymphocyte Clones, Aca demic Press, NY, 1982). However, the limitations of working with human tissues are counterbalanced by the great long-term importance of understanding disorders of human immune regulation, especially since it is becoming evident that these are far from rare. Immune deficiencies such as agammaglobulinemia and T-cell deficiencies are not common, but immune hyperresponsiveness occurring in allergy and allergiC diseases (e. g.
Editors and Affiliations
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Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College London, London, UK
Marc Feldmann
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MRC Tuberculosis and Related Infections, Hammersmith Hosptial, London, UK
Jonathan R. Lamb
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Tissue Bank, Naval Medical Research Institute, Bethesda, USA
James N. Woody
