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Thyroid Autoimmunity

  • Book
  • © 1987

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Editors:
  1. A. Pinchera

    1. University of Pisa, Pisa, Italy

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  2. S. H. Ingbar

    1. Harvard Medical School, Boston, USA

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  3. J. M. McKenzie

    1. University of Miami, Miami, USA

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  4. G. F. Fenzi

    1. University of Pisa, Pisa, Italy

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Table of contents (123 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Graves’ Disease a Paradigm For Autoimmunity

    • D. D. Adams, A. Knight, J. G. Knight, P. Laing
    Pages 1-10

  3. Nature of Thyroid Autoantigens: The TSH Receptor

    • John Chan, Michele De Luca, Pilar Santisteban, Osamu Isozaki, Sid Shifrin, Salvatore M. Aloj et al.
    Pages 11-26

  4. Progress in Understanding the Thyroid Microsomal Antigen

    • Leslie J. Degroot, Luc Portmann, Noboru Hamada
    Pages 27-34

  5. A Possible Role of Bacterial Antigens in the Pathogenesis of Autoimmune Thyroid Disease

    • Sidney H. Ingbar, Mordechai Weiss, Gary W. Cushing, Dennis L. Kasper
    Pages 35-44

  6. “ATRA 1”: a New Autoantigen in Autoimmune Thyroid Disease

    • B. Rapoport, H. Hirayu, P. Seto, R. P. Magnusson, S. Filetti
    Pages 45-52

  7. Monoclonal Antibodies in the Study of Thyriod Autoantigens and Autoantibodies

    • J. Ruf, B. Czarnocka, M. E. Toubert, C. Alquier, C. De Micco, M. Henry et al.
    Pages 53-62

  8. Lats/Tsab: Then And Now

    • J. M. McKenzie
    Pages 63-68

  9. Pathogenic Roles of TSH-Receptor Antibodies in Graves’ Disease

    • Shigenobu Nagataki
    Pages 69-76

  10. Physiopathological Relevance of Thyroid Stimulating Antibody (TSAb) Measurements in Graves’ Disease

    • Jacques Orgiazzi, Anne-Marie Madec, Rene Mornex
    Pages 77-82

  11. TSH Receptor Autoantibodies Affecting Thyroid Cell Function

    • G. F. Fenzi, P. Vitti, C. Marcocci, L. Chiovato, E. Macchia
    Pages 83-90

  12. Heterogeneity of TSH Receptor-directed Antibodies (TRAb) and Their Significance

    • Margita Zakarija
    Pages 91-98

  13. Humoral Factors in Graves’ Ophthalmopathy

    • Roberto Toccafondi, Carlo M. Rotella, Roberto Zonefrati, Annalisa Tanini
    Pages 99-108

  14. Immunoregulatory Abnormalities in Autoimmune Thyroid Disease

    • Robert Volpé, Vas V. Row
    Pages 109-115

  15. Intrathyroidal Lymphocytes, Thyroid Autoantibodies and Thyroid Destruction

    • S. M. McLachlan, C. A. S. Pegg, M. C. Atherton, S. Middleton, P. Rooke, C. Thompson et al.
    Pages 117-124

  16. Cellular Mechanism for Autoimmune Damage in Thyroid-Associated Ophthalmopathy

    • J. How, Y. Hiromatsu, P. Wang, M. Salvi, J. R. Wall
    Pages 125-133

  17. Thyroid Infiltrating T Lymphocytes in Hashimoto’s Thyroiditis: Phenotypic and Functional Analysis at Single Cell Level

    • G. F. Del Prete, A. Tiri, S. Mariotti, A. Pinchera, S. Romagnani, M. Ricci
    Pages 135-144

  18. An In Vitro Model for Thyroid Autoimmunity

    • B. E. Wenzel, R. Gutekunst, S. Grammerstorf, P. C. Scriba
    Pages 145-152

  19. Genetic Aspects Of Graves’disease

    • A. M. McGregor, S. Ratanachaiyavong, C. Gunn, K. W. Lee, P. S. Barnett, C. Darke et al.
    Pages 153-158

  20. Thyroid and Related Autoimmune Disorders: Challenging the Dogmas

    • Gian Franco Bottazzo, Ian Todd, Antonino Belfiore Rita Mirakian, Ricardo Pujol-Borrell
    Pages 159-173
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Keywords

About this book

In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.

Editors and Affiliations

  • University of Pisa, Pisa, Italy

    A. Pinchera, G. F. Fenzi

  • Harvard Medical School, Boston, USA

    S. H. Ingbar

  • University of Miami, Miami, USA

    J. M. McKenzie

Bibliographic Information

  • Book Title: Thyroid Autoimmunity

  • Editors: A. Pinchera, S. H. Ingbar, J. M. McKenzie, G. F. Fenzi

  • DOI: https://doi.org/10.1007/978-1-4613-0945-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1987

  • Softcover ISBN: 978-1-4612-8258-7Published: 18 October 2011

  • eBook ISBN: 978-1-4613-0945-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 638

  • Topics: Immunology

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