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War in the Body

The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines

  • Book
  • © 2013

Overview

Authors:
  1. W David Wick

    1. Seattle, USA

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  2. Otto O Yang

    1. Geffen School of Medicine, Department of Medicine, UCLA Medical Center, Los Angeles, USA

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    You can also search for this author in PubMed   Google Scholar

  • Explores the rapid and profound evolution of the HIV virus

  • Considers the divergent viewpoints on why and how the virus evolves

  • Addresses the ramifications of this evolution on the immune system, as well as vaccines

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xix
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  2. Introduction

    • W. David Wick, Otto O. Yang
    Pages 1-36

  3. The Biology, Modeling, and Predictions

    1. Front Matter

      Pages 37-37
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    2. The HIV Infection Model

      • W. David Wick, Otto O. Yang
      Pages 39-47

    3. The CTL Model

      • W. David Wick, Otto O. Yang
      Pages 49-53

    4. Simulating an HIV Infection In Vivo

      • W. David Wick, Otto O. Yang
      Pages 55-63

    5. The Escape Formula

      • W. David Wick, Otto O. Yang
      Pages 65-69

    6. Early and Late Escapes

      • W. David Wick, Otto O. Yang
      Pages 71-79

    7. Understanding Escape

      • W. David Wick, Otto O. Yang
      Pages 81-96

    8. More Topics About Escape from Immune Control

      • W. David Wick, Otto O. Yang
      Pages 97-111

    9. HIV’s Cloaking Device: The Fascinating Story of Nef

      • W. David Wick, Otto O. Yang
      Pages 113-122

    10. Retroviral Sex and Escape

      • W. David Wick, Otto O. Yang
      Pages 123-134

    11. The N e Business, Again, and a Proposed Experiment

      • W. David Wick, Otto O. Yang
      Pages 135-146

    12. Can a T-Cell Vaccine Block Escape?

      • W. David Wick, Otto O. Yang
      Pages 147-160

    13. The STEP Trial, Monkey Trials, and the Future of T-Cell Vaccines

      • W. David Wick, Otto O. Yang
      Pages 161-168

    14. Afterword: The RV144 Trial and the Current Status of HIV Vaccine Research

      • W. David Wick, Otto O. Yang
      Pages 169-173

  4. The Mathematics

    1. Front Matter

      Pages 175-175
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    2. Short Tutorial on Dynamical Models

      • W. David Wick, Otto O. Yang
      Pages 177-181

    3. Deterministic Modeling: A Cautionary Example

      • W. David Wick, Otto O. Yang
      Pages 183-185

    4. The Infection Model Defined

      • W. David Wick, Otto O. Yang
      Pages 187-190
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Keywords

About this book

In the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus's evolution, and the implications of these for vaccine development. The issue will be explored and explained through "ecological genetics," which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of "population genetics," which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.

Reviews

From the reviews:

“Provide a critical overview of the mathematical modeling performed so far to understand HIV immunity and escape, and advance an innovative alternative approach for stochastic simulation. … War in the Body is not a how-to guide, tutorial, or cook-book, but a research monograph, with thought exercises to cultivate problem-solving skills and foster developing plausible, stable numerical simulations.” (Complexity, March, 2014)

Authors and Affiliations

  • Seattle, USA

    W David Wick

  • Geffen School of Medicine, Department of Medicine, UCLA Medical Center, Los Angeles, USA

    Otto O Yang

About the authors

Dr. Yang is a well known T-Cell and HIV expert at UCLA. Dr. Wick is recently retired. His last position was Senior Scientist in the Infectious Diseases Division of the Fred Hutchison Center, in Seattle, where he worked on immune response to HIV and vaccines.

Bibliographic Information

  • Book Title: War in the Body

  • Book Subtitle: The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines

  • Authors: W David Wick, Otto O Yang

  • DOI: https://doi.org/10.1007/978-1-4614-7294-0

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-7293-3Published: 10 July 2013

  • Softcover ISBN: 978-1-4899-9255-0Published: 05 August 2015

  • eBook ISBN: 978-1-4614-7294-0Published: 10 July 2013

  • Edition Number: 1

  • Number of Pages: XIX, 298

  • Number of Illustrations: 47 b/w illustrations, 4 illustrations in colour

  • Topics: Virology, Immunology, Vaccine

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