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Captopril and Hypertension

  • Book
  • © 1980

Overview

Editors:
  1. David B. Case

    1. New York Hospital/Cornell Medical Center, New York, USA

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  2. Edmund H. Sonnenblick

    1. Albert Einstein College of Medicine, The Bronx, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. John H. Laragh

    1. New York Hospital/Cornell Medical Center, New York, USA

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Part of the book series: Topics in Cardiovascular Disease (TCAD)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi
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  2. Humoral and Physiological Mechanisms in Hypertension

    1. Front Matter

      Pages 1-1
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    2. Blood Pressure Homeostasis

      • Robert A. Vukovich, James R. Knill
      Pages 3-13

    3. Mechanisms of Hypertension Induced by Electrolyte-Active Steroids

      • Emmanuel L. Bravo, Harriet P. Dustan, Robert C. Tarazi
      Pages 15-23

    4. The Relationship of the Renal Medulla to the Hypertensive State

      • E. Eric Muirhead
      Pages 25-38

    5. The Influence of Various Neurological Defects on the Release of Renin in Normal Man

      • W. S. Peart
      Pages 39-56

    6. Angiotensin as a Determinant of Renal Perfusion and Function

      • Norman K. Hollenberg
      Pages 57-75

    7. Systemic Vascular Resistance

      • Jay N. Cohn
      Pages 77-86

  3. Angiotensin-Converting Enzyme

    1. Front Matter

      Pages 87-87
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    2. Physiological, Biochemical, and Immunologic Aspects of Angiotensin-Converting Enzyme

      • Richard L. Soffer, Edmund H. Sonnenblick
      Pages 89-102

    3. Design of New Antihypertensive Drugs

      • David W. Cushman, Hong Son Cheung, Emily F. Sabo, Miguel A. Ondetti
      Pages 103-113

    4. Captopril (Capoten®; SQ 14,225) (d-3-Mercapto-2-methylpropanoyl-l-proline)

      • Bernard Rubin, Michael J. Antonaccio, Zola P. Horovitz
      Pages 115-135

    5. Toxicologic and Drug Metabolic Studies of SQ 14,225 in Animals

      • G. R. Keim
      Pages 137-147

    6. Captopril

      • Hans R. Brunner, Haralambos Gavras, B. Waeber, G. A. Turini, J. P. Wauters
      Pages 149-170

  4. Clinical Use of Converting Enzyme Inhibitors

    1. Front Matter

      Pages 171-171
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    2. The Renin System in High Blood Pressure, from Disbelief to Reality

      • John H. Laragh
      Pages 173-184

    3. Experiences with Blockade of the Renin System in Human Hypertension Using Converting Enzyme Inhibitor SQ 20,881 and Saralasin

      • David B. Case, Hans J. Keim, John M. Wallace, John H. Laragh
      Pages 185-199

    4. The Use of SQ 20,881 Converting Enzyme Inhibitor (Teprotide) for Diagnostic Purposes in Hypertension

      • Haralambos Gavras, Irene Gavras, Stephen Textor, Charles P. Tifft, Glenn R. Kershaw, Hans R. Brunner
      Pages 201-210

    5. Clinical Experience with Blockade of the Renin-Angiotensin-Aldosterone System by an Oral Converting Enzyme Inhibitor (SQ 14,225, Captopril) in Hypertensive Patients

      • David B. Case, Steven A. Atlas, John H. Laragh, Jean E. Sealey, Patricia A. Sullivan, Doris N. McKinstry
      Pages 211-230

  5. Back Matter

    Pages 231-236
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Keywords

About this book

This monograph was developed from a collection of papers that were origi­ nally presented at a symposium entitled "Pathogenesis of Hypertension" held at the Henry Chauncy Conference Center, Princeton. New Jersey. These manuscripts were subsequently revised, updated, and reorganized in a manner suitable for this publication. The symposium was planned to stimu­ late interest among investigators and clinicians alike in the potential for a new class of drugs called converting enzyme inhibitors in clinical medicine. The meeting was sponsored by the Squibb Institute for Medical Research, whose pioneering biochemical and pharmaceutical research had led to the development of the first orally active converting enzyme inhibitor. It is hoped that this monograph will cohesively pull together the thesis that the identification, quantification, and containment of the renin factor in hypertension can be a powerful diagnostic and therapeutic strategy in clinical medicine. In addition, the sequence of studies presented in this manuscript will serve to demonstrate how basic biochemical and physio­ logical research produces fundamental and critical information on which subsequent major advances in clinical pharmacology and medicine can be based.

Editors and Affiliations

  • New York Hospital/Cornell Medical Center, New York, USA

    David B. Case, John H. Laragh

  • Albert Einstein College of Medicine, The Bronx, USA

    Edmund H. Sonnenblick

Bibliographic Information

  • Book Title: Captopril and Hypertension

  • Editors: David B. Case, Edmund H. Sonnenblick, John H. Laragh

  • Series Title: Topics in Cardiovascular Disease

  • DOI: https://doi.org/10.1007/978-1-4615-9179-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1980

  • Softcover ISBN: 978-1-4615-9181-8Published: 12 December 2012

  • eBook ISBN: 978-1-4615-9179-5Published: 17 April 2013

  • Edition Number: 1

  • Number of Pages: XII, 236

  • Number of Illustrations: 11 b/w illustrations

  • Topics: Cardiology

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