Overview
- Explores the effects of helminth infection on the immune response
- Provides an intellectual framework for identifying potentially new treatments for diseases associated with inflammation
- Discusses novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Keywords
About this book
The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is complex and includes effector functions that mediate resistance, contributing to expulsion and in some cases destruction, of the parasite. But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs. The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis. In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.
Editors and Affiliations
Bibliographic Information
Book Title: The Th2 Type Immune Response in Health and Disease
Book Subtitle: From Host Defense and Allergy to Metabolic Homeostasis and Beyond
Editors: William C. Gause, David Artis
DOI: https://doi.org/10.1007/978-1-4939-2911-5
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2016
Hardcover ISBN: 978-1-4939-2910-8
Softcover ISBN: 978-1-4939-4573-3
eBook ISBN: 978-1-4939-2911-5
Edition Number: 1
Number of Pages: XIV, 172
Topics: Parasitology, Immunology, Medical Microbiology