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Cancer Metabolomics

Methods and Applications

  • Book
  • © 2021

Overview

Editors:
  1. Shen Hu

    1. University of California, Los Angeles, Los Angeles, USA

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  • This book will cover the most advanced metabolomics technology
  • This book will cover state-of-the-art statistical methodology for metabolomics data analysis
  • This book will cover the most recent development on cancer biomarker discovery using metabolomics
  • This book It will highlight some of the most recent novel discovery in cancer metabolism

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1280)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xv
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  2. Chemical Isotope Labeling LC-MS for Metabolomics

    • Shuang Zhao, Liang Li
    Pages 1-18

  3. NMR-Based Metabolomics

    • G. A. Nagana Gowda, Daniel Raftery
    Pages 19-37

  4. Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research

    • Jianing Wang, Chunyan Wang, Xianlin Han
    Pages 39-55

  5. Comprehensive Two-Dimensional Gas Chromatography Mass Spectrometry-Based Metabolomics

    • Md Aminul Islam Prodhan, Craig McClain, Xiang Zhang
    Pages 57-67

  6. Single-Cell Metabolomics by Mass Spectrometry Imaging

    • Maria Emilia Dueñas, Young Jin Lee
    Pages 69-82

  7. Detection of N6-Methyladenine in Eukaryotes

    • Baodong Liu, Hailin Wang
    Pages 83-95

  8. Microbial Metabolomics: From Methods to Translational Applications

    • Rui Guo, Xialin Luo, Xu Xin, Lian Liu, Xijun Wang, Haitao Lu
    Pages 97-113

  9. Tracer-Based Cancer Metabolomic Analysis

    • Jianzhou Liu, Jing Huang, Gary Guishan Xiao
    Pages 115-130

  10. Functional Metabolomics and Chemoproteomics Approaches Reveal Novel Metabolic Targets for Anticancer Therapy

    • Chang Shao, Wenjie Lu, Haiping Hao, Hui Ye
    Pages 131-147

  11. Ion Chromatography with Mass Spectrometry for Metabolomic Analysis

    • Eoon Hye Ji, Jason Lee, Shen Hu
    Pages 149-159

  12. Quantitative Analysis of Oncometabolite 2-Hydroxyglutarate

    • Bi-Feng Yuan
    Pages 161-172

  13. Methods of Lipidomic Analysis: Extraction, Derivatization, Separation, and Identification of Lipids

    • Ya Xie, Zongyuan Wu, Zuojian Qin, Bangfu Wu, Xin Lv, Fang Wei et al.
    Pages 173-187

  14. Capillary Electrophoresis-Mass Spectrometry for Cancer Metabolomics

    • Xiangdong Xu
    Pages 189-200

  15. NMR-Based Metabolomics in Cancer Research

    • Rui Hu, Tao Li, Yunhuang Yang, Yuan Tian, Limin Zhang
    Pages 201-218

  16. Regulation of Glycolysis in Head and Neck Cancer

    • Sibi Raj, Ashok Kumar, Dhruv Kumar
    Pages 219-230

  17. Fatty Acid Metabolism and Cancer

    • Zhenning Jin, Yang D. Chai, Shen Hu
    Pages 231-241

  18. HIF-1α Metabolic Pathways in Human Cancer

    • Naseim Elzakra, Yong Kim
    Pages 243-260

  19. Metabolomics of Glioma

    • Sizhe Feng, Yutong Liu
    Pages 261-276

  20. Metabolomics of Oral/Head and Neck Cancer

    • Gaofei Yin, Junwei Huang, Wei Guo, Zhigang Huang
    Pages 277-290
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Keywords

About this book

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics.  In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism. 

Editors and Affiliations

  • University of California, Los Angeles, Los Angeles, USA

    Shen Hu

About the editor

Dr. Shen Hu is a Professor at the University of California, Los Angeles, and currently directs the Oral Biology Graduate Program. He received his PhD in Bioanalytical Chemistry from Wuhan University and MBA from the Anderson School of Management at the University of California, Los Angeles. Dr. Hu’s research interests are in cancer metabolomics, stem cell biology and single cell analysis. His laboratory is developing diagnostic tools for early cancer detection and therapeutic drugs targeting the metabolic pathways of cancer. 

Bibliographic Information

  • Book Title: Cancer Metabolomics

  • Book Subtitle: Methods and Applications

  • Editors: Shen Hu

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-030-51652-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-51651-2Published: 01 April 2021

  • eBook ISBN: 978-3-030-51652-9Published: 01 April 2021

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XV, 312

  • Number of Illustrations: 14 b/w illustrations, 66 illustrations in colour

  • Topics: Cancer Research, Molecular Medicine

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