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Epigenetic Advancements in Cancer

  • Book
  • © 2016

Overview

Editors:
  1. Manoj K. Mishra

    1. Department of Biological Sciences, Alabama State University, Montgomery, USA

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  2. Kumar S. Bishnupuri

    1. School of Medicine, Washington University, St. Louis, USA

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  • Explores epigenetic landscape that occur in various cancer cells and the role of these changes in cancer initiation and progression

  • Discusses recent technological advancements that allow epigenetic alterations in cancer to be studied across the entire genome

  • Covers a spectrum of human cancers, including prostate, ovarian, breast, gastric, pancreatic, and more

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xi
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  2. Epigenetic Control of Genes Involved in Cancer Initiation and Progression

    • Sabita N. Saldanha, Shivani Soni
    Pages 1-26

  3. Epigenetic Changes and Potential Targets in Pancreatic Cancer

    • Rajesh Singh, James W. Lillard Jr., Shailesh Singh
    Pages 27-63

  4. Epigenetic and Cancer: An Evaluation of the Impact of Dietary Components

    • James A. Stokes III, Sanjay Kumar, Karyn Scissum-Gunn, Udai P. Singh, Manoj K. Mishra
    Pages 65-78

  5. Gene Expression, Epigenetic Regulation, and Cancer

    • Shuntele N. Burns
    Pages 79-96

  6. Epigenetics of Colorectal Cancer

    • Kumar S. Bishnupuri, Manoj K. Mishra
    Pages 97-121

  7. Epigenesis in Colorectal Cancer: A Lethal Change in the Cell

    • Rashmi K. Ambasta, Dhiraj Kumar, Piyush Sawhney, Rajat Gupta, Parul Yadav, Pooja Pabari et al.
    Pages 123-144

  8. Epigenetics and Angiogenesis in Cancer

    • Niraj Kumar Jha, Saurabh Kumar Jha, Satyaprakash, Rohan Kar, Deepak Rathore, Rashmi K. Ambasta et al.
    Pages 145-176

  9. Epigenetic Post transcriptional Mutation in Neuro-Oncology

    • Ankit Tripathi, Renu Sharma, Noopur Kejriwal, Rashmi K. Ambasta, Pravir Kumar
    Pages 177-205

  10. Epigenetics of Breast Cancer: DNA Methylome and Global Histone Modifications

    • Gulistan Mese, Ozden Yalcin-Ozuysal
    Pages 207-228

  11. Enhancer of Zeste Homology 2 (Ezh2), an Epigenetic Regulator: A Possibility for Prostate Cancer Treatment

    • Sanjay Kumar, James A. Stokes III, Udai P. Singh, Kumar S. Bishnupuri, Manoj K. Mishra
    Pages 229-244

  12. Back Matter

    Pages 245-246
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Keywords

About this book

This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression.
 
Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease.

Editors and Affiliations

  • Department of Biological Sciences, Alabama State University, Montgomery, USA

    Manoj K. Mishra

  • School of Medicine, Washington University, St. Louis, USA

    Kumar S. Bishnupuri

About the editors

Manoj K. Mishra, Ph.D., is Associate Professor of Biology and founding Director of the cancer biology research and training program at Alabama State University. He has published over 25 articles, over 30 abstracts and poster exhibits, co-edited a book on Gene Regulation and Cancer, and has written over 5 book chapters. Dr. Mishra is on multiple ed boards, including the European Journal of Bioinformatics, Advances in Medical Informatics, and the International Journal of Experimental Medicine, to name a few.

Kumar S. Bishnupuri, Ph.D., is a Research Instructor in the Department of Medicine at Washington University School of Medicine. Dr. Bishnupuri has published over 16 articles, 4 book chapters, and 32 abstracts for conference symposia. He also serves as a scientific reviewer for several journals including Carcinogenesis, Frontiers in Bioscience, Cancer Biology and Therapy, Journal of Pathology, and more.

Bibliographic Information

  • Book Title: Epigenetic Advancements in Cancer

  • Editors: Manoj K. Mishra, Kumar S. Bishnupuri

  • DOI: https://doi.org/10.1007/978-3-319-24951-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-24949-0Published: 13 May 2016

  • Softcover ISBN: 978-3-319-79706-9Published: 26 May 2018

  • eBook ISBN: 978-3-319-24951-3Published: 04 May 2016

  • Edition Number: 1

  • Number of Pages: XI, 246

  • Number of Illustrations: 1 b/w illustrations, 11 illustrations in colour

  • Topics: Cancer Research, Gene Expression

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