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Skin Stress Response Pathways

Environmental Factors and Molecular Opportunities

  • Book
  • © 2016

Overview

Editors:
  1. Georg T. Wondrak

    1. Department of Pharmacology and Toxicology, College of Pharmacy & The University of Arizona Cancer Center, Department of Pharmacology and Toxicology, TUCSON, USA

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  • A unique and state of the art compilation of research examining skin environmental exposure and barrier function

  • The frontiers of molecular and clinically relevant translational dermatological research are being presented

  • The book covers a wide range of skin stress response pathways, providing a unique and comprehensive review of this field that gains much academic and industrial attention

  • Includes supplementary material: sn.pub/extras

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. The Skin Lipidome Under Environmental Stress—Technological Platforms, Molecular Pathways and Translational Opportunities

    • Florian Gruber
    Pages 1-27

  3. Squalene and Skin Barrier Function: From Molecular Target to Biomarker of Environmental Exposure

    • Boudiaf Boussouira, Dang Man Pham
    Pages 29-48

  4. Sunlight-Induced DNA Damage: Molecular Mechanisms and Photoprotection Strategies

    • Thierry Douki
    Pages 49-77

  5. Urocanic Acid and Skin Photodamage: New Light on an Old Chromophore

    • Leopold Eckhart
    Pages 79-99

  6. The Skin Extracellular Matrix as a Target of Environmental Exposure: Molecular Mechanisms, Prevention and Repair

    • Kieran T. Mellody, Mike Bell, Michael J. Sherratt
    Pages 101-125

  7. Nitric Oxide Derivatives and Skin Environmental Exposure to Light: From Molecular Pathways to Therapeutic Opportunities

    • Christoph V. Suschek
    Pages 127-154

  8. Melanocortin 1 Receptor (MC1R) as a Global Regulator of Cutaneous UV Responses: Molecular Interactions and Opportunities for Melanoma Prevention

    • Erin M. Wolf Horrell, John A. D’Orazio
    Pages 155-174

  9. The Cutaneous Melanocyte as a Target of Environmental Stressors: Molecular Mechanisms and Opportunities

    • Laurent Marrot
    Pages 175-196

  10. The Role of Epidermal p38 Signaling in Solar UV Radiation-Induced Inflammation: Molecular Pathways and Preventive Opportunities

    • Jin Mo Park, Yasuyo Sano
    Pages 197-209

  11. UV-Induced Chemokines as Emerging Targets for Skin Cancer Photochemoprevention

    • Scott N. Byrne, Gary M. Halliday
    Pages 211-234

  12. TLR3 and Inflammatory Skin Diseases: From Environmental Factors to Molecular Opportunities

    • Risa Tamagawa-Mineoka, Mayumi Ueta, Norito Katoh
    Pages 235-249

  13. Sirtuins and Stress Response in Skin Cancer, Aging, and Barrier Function

    • Yu-Ying He
    Pages 251-263

  14. Cutaneous Opioid Receptors and Stress Responses: Molecular Interactions and Opportunities for Therapeutic Intervention

    • Hanane Chajra
    Pages 265-280

  15. Regulation of Cutaneous Stress Response Pathways by the Circadian Clock: From Molecular Pathways to Therapeutic Opportunities

    • Elyse van Spyk, Milton Greenberg, Faraj Mourad, Bogi Andersen
    Pages 281-300

  16. Endocannabinoids and Skin Barrier Function: Molecular Pathways and Therapeutic Opportunities

    • Sergio Oddi, Mauro Maccarrone
    Pages 301-323

  17. The Aryl Hydrocarbon Receptor (AhR) as an Environmental Stress Sensor and Regulator of Skin Barrier Function: Molecular Mechanisms and Therapeutic Opportunities

    • Rebecca Justiniano, Georg T. Wondrak
    Pages 325-359

  18. Biological Cell Protection by Natural Compounds, a Second Line of Defense Against Solar Radiation

    • Ludger Kolbe
    Pages 361-378

  19. The Cutaneous Microbiota as a Determinant of Skin Barrier Function: Molecular Interactions and Therapeutic Opportunities

    • Julia J. van Rensburg, Lana Dbeibo, Stanley M. Spinola
    Pages 379-401

  20. Sensing Environmental Factors: The Emerging Role of Receptors in Epidermal Homeostasis and Whole-Body Health

    • Mitsuhiro Denda
    Pages 403-414
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Keywords

About this book

It is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways.  Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.   


Editors and Affiliations

  • Department of Pharmacology and Toxicology, College of Pharmacy & The University of Arizona Cancer Center, Department of Pharmacology and Toxicology, TUCSON, USA

    Georg T. Wondrak

About the editor

As an Associate Professor, Pharmacology and Toxicology, College of Pharmacy, University of Arizona and President of the American Society for Photobiology (ASP; 2016-2018), Dr. Wondrak's research examines the pathological role of oxidative and proteotoxic stress in solar photodamage and skin cancer aiming at the design of novel molecular strategies for prevention and therapeutic intervention. http://www.pharmacy.arizona.edu/directory/georg-wondrak-phd 

Bibliographic Information

  • Book Title: Skin Stress Response Pathways

  • Book Subtitle: Environmental Factors and Molecular Opportunities

  • Editors: Georg T. Wondrak

  • DOI: https://doi.org/10.1007/978-3-319-43157-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-43155-0Published: 31 August 2016

  • Softcover ISBN: 978-3-319-82750-6Published: 14 June 2018

  • eBook ISBN: 978-3-319-43157-4Published: 22 August 2016

  • Edition Number: 1

  • Number of Pages: IX, 457

  • Number of Illustrations: 29 b/w illustrations, 39 illustrations in colour

  • Topics: Biomedicine general

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