Overview
Unique resource for those looking to establish high impact research centers or units
Provides a historical account of the rationale, protocol development, implementation, and communication of a range of HIV prevention and treatment clinical trials conducted by CAPRISA
Highlights the innovative designs and measurement tools used by CAPRISA clinical trials
Includes supplementary material: sn.pub/extras
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Table of contents (16 chapters)
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Front Matter
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CAPRISA Clinical Trials for HIV and HSV-2 Prevention
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Front Matter
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CAPRISA Clinical Trials for HIV–TB Treatment
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Front Matter
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Experiences and Lessons Learnt from Clinical Trials in CAPRISA
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Front Matter
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Essential Support Activities for the Conduct of Clinical Trials
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Front Matter
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Keywords
About this book
Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA’s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics.
Comprised of 5 sections, the book details the following:
- HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV.
- CAPRISA’s clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies.
- CAPRISA’s research on the treatment of HIV and TB co-infection.
- A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology.
- Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials.
The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials – their creation, conduct and impact.
Editors and Affiliations
About the editors
Salim S. Abdool Karim, Centre for the AIDS Programme of Research in South Africa (CAPRISA); Department of Epidemiology, Columbia University, New York, USA
Cheryl Baxter, Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Bibliographic Information
Book Title: The CAPRISA Clinical Trials: HIV Treatment and Prevention
Editors: Quarraisha Abdool Karim, Salim S. Abdool Karim, Cheryl Baxter
DOI: https://doi.org/10.1007/978-3-319-47518-9
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing AG 2017
License: CC BY
Hardcover ISBN: 978-3-319-47517-2Published: 26 January 2017
Softcover ISBN: 978-3-319-83756-7Published: 29 April 2018
eBook ISBN: 978-3-319-47518-9Published: 20 January 2017
Edition Number: 1
Number of Pages: VI, 243
Number of Illustrations: 1 b/w illustrations, 23 illustrations in colour
Topics: Health Promotion and Disease Prevention, Infectious Diseases, Health Informatics