Overview
- Nominated by the Weizmann Institute, Israel for a Springer Theses Prize
- This research has already led to attempts to improve PTC antibiotics
- Based on these findings further research into designing a functional construct mimicking a functional proto-ribosome has been initiated
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (4 chapters)
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Front Matter
Keywords
About this book
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
Authors and Affiliations
Bibliographic Information
Book Title: Targeting Functional Centers of the Ribosome
Authors: Chen Davidovich
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-642-16931-1
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2011
Hardcover ISBN: 978-3-642-16930-4Published: 03 February 2011
Softcover ISBN: 978-3-642-26705-5Published: 21 April 2013
eBook ISBN: 978-3-642-16931-1Published: 02 February 2011
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XIV, 74
Topics: Nucleic Acid Chemistry, Protein Science, Organic Chemistry