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Metallocorroles for Attenuation of Atherosclerosis

  • Book
  • © 2012

Overview

Authors:
  1. Adi Haber

    1. , Schulich Faculty of Chemistry, Technion Israel Institute of Technology, Haifa, Israel

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  • Nominated by the Technion Israel Institute of Technology as an outstanding PhD thesis
  • Covers a complete study from pure chemistry through biochemical and cell culture tests to in vivo examinations
  • Describes the way forward for ongoing regulated preclinical studies to develop metallocorroles as potential drugs
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-xix
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  2. Introduction

    • Adi Haber
    Pages 1-14

  3. Research Goals

    • Adi Haber
    Pages 15-15

  4. Results

    • Adi Haber
    Pages 17-44

  5. Discussion

    • Adi Haber
    Pages 45-66

  6. Conclusions

    • Adi Haber
    Pages 67-69

  7. Materials and Methods

    • Adi Haber
    Pages 71-86

  8. Back Matter

    Pages 87-87
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Keywords

About this book

Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases.

Authors and Affiliations

  • , Schulich Faculty of Chemistry, Technion Israel Institute of Technology, Haifa, Israel

    Adi Haber

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