Overview
- Editors:
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Hermann Lang
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Biochemical Research Institute, E. Merck Darmstadt, Darmstadt 1, Germany
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Table of contents (12 chapters)
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Front Matter
Pages I-XVIII
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- H. D. Orth, H. E. Blum, B. Webber, B. Deus, W. Gerok
Pages 10-30
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- R. Helger, N. Hennrich, U. Würzburg, W. Rick, U. Schwarze-Gross, D. Neumeier
Pages 31-84
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- D. Neumeier, E. Jockers-Wretou
Pages 85-131
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- D. Neumeier, W. Prellwitz, M. Knedel, B. Kemkes, E. Schmidt, F. W. Schmidt et al.
Pages 132-169
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- W. Prellwitz, H. G. Benkmann, G. Chemnitz, E. Schmidt, F. W. Schmidt
Pages 170-194
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- W. Prellwitz, G. Chemnitz, J. Haas, E. Schmidt, F. W. Schmidt
Pages 195-206
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- W. Prellwitz, G. Chemnitz, E. Schmidt, F. W. Schmidt
Pages 215-223
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- G. Chemnitz, H. Schlebusch, E. Schmidt, F. W. Schmidt, G. Garstka, L. Nevermann et al.
Pages 224-241
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Back Matter
Pages 270-320
About this book
No one has counted the enzymes in the human organism, and probably their profuse number can only be estimated from the restrictions the finite mass of genetic material imposes. Still, nu merous catalytic activities have been identified and investigated for their clinical relevance. After one century of such research, surprisingly, only a handful of enzymes has survived the stern trial of clinical application to find regular medical use. Dis regarding genetic defects, most of the diagnostically used en zymes participate in metabolic conversions fundamental to life: the utilization, transfer or fixation of vital nutrients or of cheJ,llical energy. Creatine kinase is central to the function of the mitochond rion, the cellular power generator. The wider distribution of this enzyme is linked to tissues whose physiology crucially relies on an adaptable supply of energy, notably skeletal muscle, the brain, and the heart. Just as these three tissues vary in their pre ference for different energy sources, each produces a different isoenzyme of creatine kinase. Accordingly, the finding of elevat ed creatine kinase activity in blood can lead to a variety of interpretations, but in practice the diagnosis of acute myocardial infarction is the major consideration.
Editors and Affiliations
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Biochemical Research Institute, E. Merck Darmstadt, Darmstadt 1, Germany
Hermann Lang
