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Immune Deficiency

  • Book
  • © 1979

Overview

Editors:
  1. Max D. Cooper

    1. Cellular Immunobiology Unit of the Tumor Institute, Departments of Pediatrics and Microbiology and the Comprehensive Cancer Center, University of Alabama, Birmingham, USA

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  2. A. R. Lawton

    1. 224 Tumor Institute, University of Alabama, Birmingham, USA

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  3. P. A. Miescher

    1. Division d’Hématologie du Departement de Médicine, Hôpital Cantonal, Genève, Switzerland

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  4. H. J. Mueller-Eberhard

    1. Departments of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

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Table of contents (9 chapters)

  1. Front Matter

    Pages I-VI
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  2. Introduction

    • M. D. Cooper, A. R. Lawton
    Pages 1-3

  3. T Cell Disorders in Primary Immunodeficiency Diseases

    • Thomas A. Waldmann, Samuel Broder
    Pages 5-30

  4. Primary Antibody Deficiencies

    • M. D. Cooper, A. R. Lawton, J. L. Preud’homme, M. Seligmann
    Pages 31-47

  5. Severe Combined Immunodeficiency Diseases

    • W. H. Hitzig, L. J. Dooren, J. M. Vossen
    Pages 49-64

  6. Enzyme Defects in Immunodeficiency Diseases

    • Rochelle Hirschhorn, David W. Martin Jr.
    Pages 65-87

  7. Phagocytic Defects

    • Paul G. Quie, Elaine L. Mills, Linda C. McPhail, Richard B. Johnston Jr.
    Pages 89-103

  8. Genetic Defects of Complement in Man

    • Peter J. Lachmann, Fred S. Rosen
    Pages 105-119

  9. Treatment of the Immunodeficiency Diseases — Progress Toward Replacement Therapy Emphasizing Cellular and Macromolecular Engineering

    • Rajendra Pahwa, Savita Pahwa, Richard O’Reilly, Robert A. Good
    Pages 121-170

  10. The Thymus: Its Influence on Recognition of “Self Major Histocompatibility Antigens” by T Cells and Consequences for Reconstitution of Immunodeficiency

    • Rolf M. Zinkernagel
    Pages 171-181

  11. Back Matter

    Pages 183-186
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Keywords

About this book

The subject of immune deficiency has become of special importance for two reasons. First, conditions with well defined defects in the immune system could be analyzed as "experiments of nature" in terms of finding out the accurate biological relevance of the defective link in the immune system. Secondly, the recognition of immune deficiency states has become important in order to provide the patients with the treatment necessary to remedy these defects. With regard to immune deficiency states in patients, these have been instrumental as "experiments of nature" in the revelation by Drs. Good and Cooper and their associates of the two-component structure of the immune system, a discovery which can be consi­ dered as a major breakthrough in the history of immunopathology. Today's research allows us to go far beyond this basic two­ component structure with the assessment of disorders affecting either cell to cell interactions or regarding subsets of lymphocyte populations. Furthermore, the association of immune deficiency with distinct enzymatic defects of purine metabolism is opening the door to the molecular level of immune deficiency. Dr. Cooper and Dr. Lawton have succeeded in obtaining the collaboration of the leaders in the field of immune deficiency. In view of the importance of their contributions in scientific and clinical terms, we decided to prepare a book version of the two issues of Seminars in Immunopathology devoted to this subject.

Editors and Affiliations

  • Cellular Immunobiology Unit of the Tumor Institute, Departments of Pediatrics and Microbiology and the Comprehensive Cancer Center, University of Alabama, Birmingham, USA

    Max D. Cooper

  • 224 Tumor Institute, University of Alabama, Birmingham, USA

    A. R. Lawton

  • Division d’Hématologie du Departement de Médicine, Hôpital Cantonal, Genève, Switzerland

    P. A. Miescher

  • Departments of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

    H. J. Mueller-Eberhard

Bibliographic Information

  • Book Title: Immune Deficiency

  • Editors: Max D. Cooper, A. R. Lawton, P. A. Miescher, H. J. Mueller-Eberhard

  • DOI: https://doi.org/10.1007/978-3-642-81362-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1979

  • Softcover ISBN: 978-3-540-09490-6Published: 01 August 1979

  • eBook ISBN: 978-3-642-81362-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VI, 186

  • Additional Information: Monograph edition of: Springer Seminars in Immunopathology, Vol. 1, Numbers 3 and 4, 1978

  • Topics: Immunology, Allergology

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