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Transgenic Animals as Model Systems for Human Diseases

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. Erwin F. Wagner

    1. Research Institute of Molecular Pathology (IMP), Vienna, Austria

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  2. Franz Theuring
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Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 6)

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Table of contents (9 papers)

  1. Front Matter

    Pages I-XII
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  2. The Human Renin-Angiotensin System in Transgenic Rats — New Tools for Antihypertensive Therapy

    • Jürgen Wagner, Martin Paul, Detlev Ganten
    Pages 1-23

  3. Probing the Genetics of Atherosclerosis in Transgenic Mice

    • Edward Rubin, Joshua Schultz
    Pages 25-37

  4. The PrP-less Mouse: A Tool for Prion Research

    • Charles Weissmann, Hansruedi Büeler, Marek Fischer, Michel Aguet
    Pages 39-56

  5. The Carboxyterminal Fragment of the Alzheimer Amyloid Protein Precursor Causes Neurodegeneration In Vivo

    • Rachael L. Neve, Michael R. Kozlowski, Anja Kammerscheidt, Christine F. Hohmann
    Pages 57-72

  6. Transgenic Models of Chronic Arthritis and of Systemic Tumour Necrosis Factor-Mediated Disease in Mice Expressing Human Tumour Necrosis Factor

    • George A. Kollias
    Pages 73-90

  7. Mammary Neoplasia in Mouse Mammary Tumor Virus-Transforming Growth Factor α Transgenic Mice

    • Robert J. Coffey, Peter J. Dempsey
    Pages 91-108

  8. Exploring the Pathogenic Potential of c-fos, Polyoma Middle T and Human Foamy Virus in Transgenic Mice

    • Erwin F. Wagner, Adriano Aguzzi
    Pages 109-128

  9. Transgenic Animals as Bioreactors for Therapeutic and Nutritional Proteins

    • Lothar Hennighausen, Avi Shamay, Priscilla A. Furth, Robert A. McKnight, Caird Rexroad Jr., Vern G. Pursel et al.
    Pages 129-141

  10. Targeted Inactivation of the Muscle Regulatory Genes Myf-5 and MyoD: Effect on Muscle and Skeletal Development

    • Michael A. Rudnicki, Thomas Braun, Hans-Henning Arnold, Rudolf Jaenisch
    Pages 143-151
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Keywords

About this book

Some of the current concepts used in transgenic research, an increasingly important tool to study the regulation and function of genes, are illustrated in this book. With these techniques, animal models can be used to study human diseases; this opens up new possibilities in both applied and basic research. Specifically, the ability to introduce genes into the germline of mice and the successful expression of the inserted gene within an organism provide new insights and opportunities for biomedical research. The discussion here shows how a detailed analysis of the underlying molecular mechanisms will provide new insights into the genetic origin of certain diseases and will lead to a better understanding of normal and abnormal physiological processes.

Editors and Affiliations

  • Research Institute of Molecular Pathology (IMP), Vienna, Austria

    Erwin F. Wagner

Bibliographic Information

  • Book Title: Transgenic Animals as Model Systems for Human Diseases

  • Editors: Erwin F. Wagner, Franz Theuring

  • Series Title: Ernst Schering Foundation Symposium Proceedings

  • DOI: https://doi.org/10.1007/978-3-662-02925-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1993

  • Softcover ISBN: 978-3-662-02927-5Published: 22 November 2012

  • eBook ISBN: 978-3-662-02925-1Published: 17 April 2013

  • Series ISSN: 0947-6075

  • Edition Number: 1

  • Number of Pages: XII, 151

  • Number of Illustrations: 77 b/w illustrations

  • Topics: Biomedical Engineering and Bioengineering, Medical Microbiology

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