Overview
- Editors:
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Wolfgang Walther
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Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Ulrike Stein
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Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Table of contents (39 protocols)
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Experimental Approaces To Cancer Gene Therapy
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- Mario P. Colombo, Monica Rodolfo
Pages 3-26
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- Thomas Tüting, Andreas Albers
Pages 27-47
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- Katalin V. Lukacs, Artit Nakakes
Pages 49-56
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- Ingo Drexler, Karl Heller, Marion Ohlmann, Volker Erfle, Gerd Sutter
Pages 57-73
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Experimental Approaces To Cancer Gene Therapy
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- Jodi E. D. Hecht, David J. Waxman
Pages 77-83
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- Jodi E. D. Hecht, Youssef Jounaidi, David J. Waxman
Pages 85-94
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- Jodi E. D. Hecht, David J. Waxman
Pages 95-105
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- Jodi E. D. Hecht, Pamela Schreiber Schwartz, David J. Waxman
Pages 107-118
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Experimental Approaces To Cancer Gene Therapy
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- Guadalupe Bilbao, Jesus Gomez-Navarro, Keizo Kazano, Juan Luis Contreras, David T. Curiel
Pages 121-149
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- Karsten Brand, Volker Sandig, Michael Strauss
Pages 151-163
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Experimental Approaces To Cancer Gene Therapy
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- Doriano Fabbro, B. P. Monia, K.-H. Altmann, Thomas Geiger
Pages 167-188
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- Yue Xin Pan, Donald D. Anthony
Pages 189-204
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Experimental Approaces To Cancer Gene Therapy
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- Takao Ohnuma, Hiroyuki Kobayashi, Fu-Sheng Wang
Pages 207-245
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- Toshiya Suzuki, Masami Bessho, Kevin J. Scanlon
Pages 247-260
About this book
Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes have been extensively st- ied. All these strategies aim for the selective destruction of human malignant disease while circumventing the destruction of nonmalignant cells and tissues thereby minimizing toxicity to the patient.
Reviews
"A wide variety of methods used to deliver genes to tumors are discussed, as are the type of genes used. This includes tumor vaccination, suicide genes, antisense genes, ribozymes, etc. The unique aspect of this book is the translational approach of explaining laboratory techniques as well as the application to patients. . .This book is well written and a translational resource for those interested in the rapidly advancing and novel field of gene therapy for malignancies."-Doody's Health Science Book Review Journal
