Overview
- Editors:
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Christof M. Niemeyer
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Fachbereich Chemie der Universität Dortmund, Dortmund, Germany
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Table of contents (23 protocols)
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Antibody and Enzyme Conjugates
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- Vladimir V. Shuvaev, Thomas Dziubla, Rainer Wiewrodt, Vladimir R. Muzykantov
Pages 3-19
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- Silvia Muro, Vladimir R. Muzykantov, Juan-Carlos Murciano
Pages 21-36
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- Patrick S. Stayton, Zhongli Ding, Allan S. Hoffman
Pages 37-43
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- Margherita Morpurgo, Francesco M. Veronese
Pages 45-70
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- Robert F. Graziano, Paul Guptill
Pages 71-85
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Nucleic Acid Conjugates
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Front Matter
Pages 125-125
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- Verena Beier, Andrea Bauer, Michael Baum, Jörg D. Hoheisel
Pages 127-135
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- Goran Pljevaljčić, Falk Schmidt, Alexander Peschlow, Elmar Weinhold
Pages 145-161
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- Florian Kukolka, Marina Lovrinovic, Ron Wacker, Christof M. Niemeyer
Pages 181-196
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- Kunihiro Kaihatsu, David R. Corey
Pages 207-214
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Glycosyl and Lipid Conjugates
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Front Matter
Pages 215-215
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- Ines Heinemann, Martin Völkert, Herbert Waldmann
Pages 221-232
About this book
There are a number of outstanding volumes that provide a comprehensive overview of bioconjugation techniques. However, many of the conventional approaches to the synthesis of chemically modified protein conjugates lack efficient means to control the stoichiometry of conjugation, as well as the s- cific site of attachment of the conjugated moiety. Moreover, the recent dev- opments in microarray technologies as well as in nanobiotechnology—a novel field of research rapidly evolving at the crossroads of physics, chemistry, b- technology, and materials science—call for a summary of modern bioconjugation strategies to overcome the limitations of the classical approaches. Bioconjugation Protocols: Methods and Strategies is intended to provide an update of many of the classic techniques and also to introduce and summarize newer approaches that go beyond the pure biomedical applications of bioconjugation. The purpose of Bioconjugation Protocols: Methods and Str- egies is therefore to provide instruction and inspiration for all those scientists confronting the challenges of semisynthesizing functional biomolecular reagents for a wide variety of applications ranging from novel biomedical diagnostics, to therapeutics, to biomaterials. Part I contains seven protocols for the preparation of protein conjugates.
Reviews
"...provides highlights for scientists who are pioneering in the synthesis of biofunctional macromolecules, as well as providing resources to all levels of scientists who are engaged in the fields of diagnostics, biomaterials, and pharmacotherapeutics." - Journal of Medicinal Chemistry
Editors and Affiliations
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Fachbereich Chemie der Universität Dortmund, Dortmund, Germany
Christof M. Niemeyer
