Abstract
Tyrosine Hydroxylase is the rate-limiting enzyme in the synthesis of dopamine, and as such, it is widely used as a marker of dopaminergic cells. Within the basal ganglia, the dopaminergic cells are located in the substantia nigra pars compacta, and project to the striatum. It is this pathway which degenerates during Parkinson's disease. The data presented here illustrate examples of tyrosine-hydroxylase immunoreactive cells in striatum following intrastriatal injection with the neurotoxin MPP+. We further show by electron microscopy that these cells are, in fact, neurons and that they possess ultrastructural features of interneurons.
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Tipton, K.F. and Singer, T.P., 1993, Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem. 61,1191–1206.
OByrne, M.B. and Tipton, K.F., 2000, Taurine-induced attenuation of MPP+ neurotoxicity in vitro. J. Neurochem. in press.
Paxinos, G and Watson C., 1987 The rat brain in stereotaxic co-ordinates. Academic Press, London.
Bob, J.P, 1992, Editor: Experimental Neuroanatomy: A Practical Approach. (Series editors: D. Rickwood and B.D. Hames). Oxford University Press (IRL), Oxford, UK.
Tashiro, Y., Kaneko, T., Sugimoto, T., Nagatsu, I., Kikuchi, H. and Mizuno, N., 1989, Striatal neurons with aromatic L-amino acid decarboxylase-like immunoreactivity in the rat. Neurosci. Lett. 100, 29–34.
Mura, A., Jackson, D., Manley, S.M., Young, S.J. and Groves, P.M. (1995) Aromatic Lamino acid decarboxylase immunoreactive cells in the rat striatum: a possible site for the conversion of exogenous L-DOPA to dopamine. Brain Res. 704, 51–60.
Meredith, G.E., Farrell, T., Kellaghan, P., Tan, Y., Zahm, D.S. and Totterdell, S., 1999, Immunocytochemical characterization of catecholaminergic neurons in the rat striatum following dopaminedepleting lesions. Eur. J. Neurosci. 11,3585–96.
Smith, A.D., and Bolam, J.P., 1990, The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones. TINS, 13: 259–285.
Aoki, C. and Pickel, V.M., 1988, Neuropeptide-Y-containing neurons in the striatum: ultrastructure and cellular relations with tyrosine-hydroxylase-containing terminals and with astrocytes. Brain Res. 459, 205–225.
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© 2002 Kluwer Academic Publishers
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O'Byrne, M.B., Bolam, J.P., Hanley, J.J., Tipton, K.F. (2002). Tyrosine-Hydroxylase Immunoreactive Cells in the Rat Striatum Following Treatment with MPP+. In: Della Corte, L., Huxtable, R.J., Sgaragli, G., Tipton, K.F. (eds) Taurine 4. Advances in Experimental Medicine and Biology, vol 483. Springer, Boston, MA. https://doi.org/10.1007/0-306-46838-7_41
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DOI: https://doi.org/10.1007/0-306-46838-7_41
Publisher Name: Springer, Boston, MA
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