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Acid Sphingomyelinase-derived Ceramide Signaling in Apoptosis

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Phospholipid Metabolism in Apoptosis

Part of the book series: Subcellular Biochemistry ((SCBI,volume 36))

Conclusions

A variety of studies demonstrate a central role for ASM and ceramide in several forms of apoptosis. Ceramide seems to regulate the activity of certain proteins and, thus, may function, in some circumstances, as a second messenger. In addition, the concept of raft modification by ceramide provides a comprehensive model for cellular effects of ceramide, and perhaps a biophysical explanation for the diverse functions of this lipid.

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Authors and Affiliations

  1. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105

    Erich Gulbins

  2. Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, NY, 10021

    Richard Kolesnick

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  1. Erich Gulbins
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Editors and Affiliations

  1. Kings College London, London, UK

    Peter J. Quinn

  2. University of Pittsburgh, Pittsburgh, Pennsylvania

    Valerian E. Kagan

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Gulbins, E., Kolesnick, R. (2004). Acid Sphingomyelinase-derived Ceramide Signaling in Apoptosis. In: Quinn, P.J., Kagan, V.E. (eds) Phospholipid Metabolism in Apoptosis. Subcellular Biochemistry, vol 36. Springer, Boston, MA. https://doi.org/10.1007/0-306-47931-1_12

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  • DOI: https://doi.org/10.1007/0-306-47931-1_12

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