Skip to main content

Radiofrequency Ablation of Colon and Rectal Carcinoma Liver Metastases

  • Chapter
Radiofrequency Ablation for Cancer

Conclusion

Although surgical resection remains the “gold standard” for potentially curative therapy for colorectal carcinoma liver metastases, recent improvements in RFA technology have provided patients and physicians with a new treatment option. Advances in RFA device technology, imaging modalities, and minimally invasive tools offer the promise of a more effective and less invasive treatment in the future. The pace with which advances have been made in RFA for liver tumors has added to the excitement in the field. RFA will presumably complement established therapies, including regional and systemic chemotherapy and resection. Results of small, single-institution clinical trials evaluating RFA in this role are promising. Large-scale clinical trials and more long-term outcome data are needed to evaluate the efficacy and role of RFA for the treatment of liver metastases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cosman ER, Nashold BS, Ovelman-Levitt J. Theoretical aspects of radiofrequency lesions in the dorsal root entry zone. Neurosurgery 1984; 15:945–950.

    PubMed  CAS  Google Scholar 

  2. Organ LW. Electrophysiologic principles of radiofrequency lesion making. Appl Neurophysiol 1976; 39:69–76.

    PubMed  Google Scholar 

  3. Goldberg SN, Gazelle GS, Dawson SL, Rittman WJ, Mueller PR, Rosenthal DI. Tissue ablation with radiofrequency using multiprobe arrays. Acad Radiol 1995; 2:670–674.

    PubMed  CAS  Google Scholar 

  4. Rossi S, Buscarini E, Garbagnati F, et al. Percutaneous treatment of small hepatic tumors by an expandable RF needle electrode. AJR 1998; 170:1015–1022.

    PubMed  CAS  Google Scholar 

  5. Lencioni R, Cioni D, Bartolozzi C. Percutaneous radiofrequency thermal ablation of liver malignancies: techniques, indications, imaging findings, and clinical results. Abdom Imaging 2001; 26: 345–360.

    Article  PubMed  CAS  Google Scholar 

  6. Siperstein AE, Rogers SJ, Hansen PD, Gitomirsky A. Laparoscopic thermal ablation of hepatic neuroendocrine tumor metastases. Surgery 1997; 122:1147–1155.

    Article  PubMed  CAS  Google Scholar 

  7. Livraghi T, Goldberg SN, Monti F, et al. Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology 1997; 202:205–210.

    PubMed  CAS  Google Scholar 

  8. Mittleman RS, Huang SK, de Guzman WT, Cuenoud H, Wagshal AB, Pires LA. Use of the saline infusion electrode catheter for improved energy delivery and increased lesion size in radiofrequency catheter ablation. Pacing Clin Electrophysiol 1995; 18:1022–1027.

    PubMed  CAS  Google Scholar 

  9. Miao Y, Ni Y, Yu J, Zhang H, Baert A, Marchal G. An ex vivo study on radiofrequency tissue ablation: increased lesion size by using an “expandable-wet” electrode. Eur Radiol 2001; 11:1841–1847.

    Article  PubMed  CAS  Google Scholar 

  10. Goldberg SN, Ahmed M, Gazelle GS, et al. Radio-frequency thermal ablation with NaCl solution injection: effect of electrical conductivity on tissue heating and coagulation-phantom and porcine liver study. Radiology 2001; 219:157–165.

    PubMed  CAS  Google Scholar 

  11. Goldberg SN, Kruskal JB, Oliver BS, Clouse ME, Gazelle GS. Percutaneous tumor ablation: increased coagulation by combining radio-frequency ablation and ethanol instillation in a rat breast tumor model. Radiology 2000; 217:827–831.

    PubMed  CAS  Google Scholar 

  12. Lorentzen T. A cooled needle electrode for radiofrequency tissue ablation: thermodynamic aspects of improved performance compared with conventional needle design. Acad Radiol 1996; 3:556–563.

    Article  PubMed  CAS  Google Scholar 

  13. Rossi S, Garbagnati F, De Francesco I, et al. Relationship between the shape and size of radiofrequency induced thermal lesions and hepatic vascularization. Tumori 1999; 85:128–132.

    PubMed  CAS  Google Scholar 

  14. Patterson EJ, Scudamore CH, Owen DA, Nagy AG, Buczkowski AK. Radiofrequency ablation of porcine liver in vivo: effects of blood flow and treatment time on lesion size. Ann Surg 1998; 227:559–565.

    Article  PubMed  CAS  Google Scholar 

  15. Goldberg SN, Hahn PF, Tanabe KK, et al. Percutaneous radiofrequency tissue ablation: does perfusion-mediated tissue cooling limit coagulation necrosis? J Vasc Intervent Radiol 1998; 9:101–111.

    Article  CAS  Google Scholar 

  16. Goldberg SN, Gazelle GS, Compton CC, Mueller PR, Tanabe KK. Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer 2000; 88:2452–2463.

    Article  PubMed  CAS  Google Scholar 

  17. de Baere T, Bessoud B, Dromain C, et al. Percutaneous radiofrequency ablation of hepatic tumors during temporary venous occlusion. AJR 2002; 178:53–59.

    PubMed  Google Scholar 

  18. Goldberg SN, Gazelle GS, Solbiati L, Mullin K. Large volume radiofrequency tissue ablation: increase coagulation with pulsed technique. Radiology 1997; 205:P258 (abstract).

    Google Scholar 

  19. Goldberg SN, Stein MC, Gazelle G, Sheiman RG, Kruskal JB, Clouse ME. Percutaneous radiofrequency tissue ablation: optimization of pulsed-radiofrequency technique to increase coagulation necrosis. J Vasc Intervent Radiol 1999; 10:907–916.

    Article  CAS  Google Scholar 

  20. Bowles BJ, Machi J, Limm WM, et al. Safety and efficacy of radiofrequency thermal ablation in advanced liver tumors. Arch Surg 2001; 136:864–869.

    Article  PubMed  CAS  Google Scholar 

  21. Curley SA, Izzo F, Delrio P, et al. Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients. Ann Surg 1999; 230:1–8.

    Article  PubMed  CAS  Google Scholar 

  22. Dominique E, El Otmany A, Goharin A, Attalah D, de Baere T. Intraductal cooling of the main bile ducts during intraoperative radiofrequency ablation. J Surg Oncol 2001; 76:297–300.

    Article  PubMed  CAS  Google Scholar 

  23. Siperstein A, Garland A, Engle K, et al. Laparoscopic radiofrequency ablation of primary and metastatic liver tumors. Technical considerations. Surg Endosc 2000; 14:400–405.

    Article  PubMed  CAS  Google Scholar 

  24. Kuszyk BS, Choti MA, Urban BA, et al. Hepatic tumors treated by cryosurgery: normal CT appearance. AJR 1996; 166:363–368.

    PubMed  CAS  Google Scholar 

  25. Chopra S, Dodd GD, 3rd, Chintapalli KN, Leyendecker JR, Karahan OI, Rhim H. Tumor recurrence after radiofrequency thermal ablation of hepatic tumors: spectrum of findings on dual-phase contrastenhanced CT. AJR 2001; 177:381–387.

    PubMed  CAS  Google Scholar 

  26. Berber E, Foroutani A, Garland AM, et al. Use of CT Hounsfield unit density to identify ablated tumor after laparoscopic radiofrequency ablation of hepatic tumors. Surg Endosc 2000; 14:799–804.

    Article  PubMed  CAS  Google Scholar 

  27. Solbiati L, Ierace T, Goldberg SN, et al. Percutaneous US-guided radio-frequency tissue ablation of liver metastases: treatment and follow-up in 16 patients [see comments]. Radiology 1997; 202:195–203.

    PubMed  CAS  Google Scholar 

  28. Solbiati L, Livraghi T, Goldberg SN, et al. Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: longterm results in 117 patients. Radiology 2001; 221:159–166.

    PubMed  CAS  Google Scholar 

  29. Chinn SB, Lee FT Jr, Kennedy GD, et al. Effect of vascular occlusion on radiofrequency ablation of the liver: results in a porcine model. AJR 2001; 176:789–795.

    PubMed  CAS  Google Scholar 

  30. Kemeny N, Huang Y, Cohen AM, et al. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med 1999; 341:2039–2048.

    Article  PubMed  CAS  Google Scholar 

  31. Wood TF, Rose DM, Chung M, Allegra DP, Foshag LJ, Bilchik AJ. Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations, and complications. Ann Surg Oncol 2000; 7:593–600.

    PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Tanabe, K.K., Choti, M.A. (2004). Radiofrequency Ablation of Colon and Rectal Carcinoma Liver Metastases. In: Radiofrequency Ablation for Cancer. Springer, New York, NY. https://doi.org/10.1007/0-387-21598-0_2

Download citation

  • DOI: https://doi.org/10.1007/0-387-21598-0_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-95564-3

  • Online ISBN: 978-0-387-21598-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics