Skip to main content
SpringerLink
Log in

Biological Action of Adrenomedullin

  • Chapter
Adrenomedullin in Cardiovascular Disease

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 19))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abe K, Minegishi T, Tano M, Hirakawa T, Tsuchiya M, Kangawa K, Kojima M, and Ibuki Y (1998) Expression and effect of adrenomedullin on rat granulosa cell. Endocrinology 139:5263–5266.

    Article  PubMed  Google Scholar 

  • Abe M, Sata M, Nishimatsu H, Nagata D, Suzuki E, Terauchi Y, Kadowaki T, Minamino N, Kangawa K, Matsuo H, Hirata Y, and Nagai R (2003) Adrenomedullin augments collateral development in response to acute ischemia. Biochem Biophys Res Commun 306:10–15.

    Article  PubMed  Google Scholar 

  • Allaker RP, Zihni C, and Kapas S. (1999) An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora. FEMS Immunol Med Microbiol 23:289–293.

    Article  PubMed  Google Scholar 

  • Andreis PG, Markowska A, Champion HC, Mazzocchi G, Malendowicz LK, and Nussdorfer GG. (2000) Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: receptor subtype involved and signaling mechanism. Endocrinology 141:2098–2104.

    Article  PubMed  Google Scholar 

  • Andreis PG, Mazzocchi G, Rebuffat P, and Nussdorfer GG. (1997a) Effects of adrenomedullin and proadrenomedullin N-terminal 20 peptide on rat zona glomerulosa cells. Life Sci 60:1693–1697.

    Article  PubMed  Google Scholar 

  • Andreis PG, Neri G, Prayer GT, Rossi GP, Gottardo G, Malendowicz LK, and Nussdorfer GG. (1997b) Effects of adrenomedullin on the human adrenal glands: an in vitro study. J Clin Endocrinol Metab 82:1167–1170.

    Article  PubMed  Google Scholar 

  • Asada Y, Hara S, Marutsuka K, Kitamura K, Tsuji T, Sakata J, Sato Y, Kisanuki A, Eto T, and Sumiyoshi A. (1999) Novel distribution of adrenomedullin-immunoreactive cells in human tissues. Histochem Celi Biol 112:185–191.

    Article  Google Scholar 

  • Belloni AS, Trejter M, Malendowicz LK, and Nussdorfer GG. (2003) Adrenomedullin stimulates proliferation and inhibits apoptosis of immature rat thymocytes cultured in vitro. Peptides 24:295–300.

    Article  PubMed  Google Scholar 

  • Beltowski J and Jamroz A. (2004) Adrenomedullin — what we know 10 years since its discovery? Poi J Pharmacol 56:5–27.

    Google Scholar 

  • Chini EN, Chini CC, Bolliger C, Jougasaki M, Grande JP, Bumett JC Jr, and Dousa TP. (1997) Cytoprotective effects of adrenomedullin in glomerular cell injury: central role of cAMP signaling pathway. Kidney Int 52:917–925.

    PubMed  Google Scholar 

  • Clementi G, Caruso A, Cutuli VMC, deBemardis E, Prato A, Mangano NG, and Amico-Roxas M. (1998) Effects of centrally or peripherally injected adrenomedullin on reserpine-induced gastric lesions. Eur J Pharmacol 360:51–54.

    Article  PubMed  Google Scholar 

  • Clementi G, Caruso A, Cutuli VM, Prato A, Mangano NG, and Amico-Roxas M. (1999) Antiinflammatory activity of adrenomedullin in the acetic acid peritonitis in rats. Life Sci 65:PL203–PL208.

    Article  PubMed  Google Scholar 

  • Comish J, Callon KE, Coy DH, Jiang NY, Xiao L, Cooper GJ, and Reid IR. (1997) Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo. Am J Physiol 273:E1113–E1120.

    PubMed  Google Scholar 

  • Dogan A, Suzuki Y, Koketsu N, Osuka K, Saito K, Takayasu M, Shibuya M, and Yoshida J. (1997) Intravenous infusion of adrenomedullin and increase in regional cerebral blood flow and prevention of ischemic brain injury after middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 17:19–25.

    Article  PubMed  Google Scholar 

  • Ebara T, Miura K, Okumura M, Matsuura T, Kim S, Yukimura T, and Iwao H. (1994) Effect of adrenomedullin on renal hemodynamics and functions in dogs. Eur J Phannrmacol 263:69–73.

    Article  Google Scholar 

  • Edwards RM, Trizna W, Stack E, and Aiyar N. (1996) Effect of adrenomedullin on cAMP levels along the rat nephron: comparison with CGRP. Am J Physiol 271:F895–F899.

    PubMed  Google Scholar 

  • Eguchi S, Hirata Y, Kano H, Sato K, Watanabe Y, Watanabe TX, Nakajima K, Sakakibara S, and Marumo F. (1994) Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells. FEBS Lett 340:226–230.

    Article  PubMed  Google Scholar 

  • Hagner S, Stahl U, Knoblauch B, McGregor GP, and Lang RE. (2002) Calcitonin receptor-like receptor: identification and distribution in human peripheral tissues. Cell Tissue Res 310:41–50.

    Article  PubMed  Google Scholar 

  • Hamada H, Kitamura K, Chosa E, Eto T, and Tajima N. (2002) Adrenomedullin stimulates the growth of cultured normal human osteoblasts as an autocrine/paracrine regulator. Peptides 23:2163–2168.

    Article  PubMed  Google Scholar 

  • Hinson JP, Kapas S, and Smith DM. (2000) Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 21:138–167.

    Article  PubMed  Google Scholar 

  • Hirata Y, Hayakawa H, Suzuki Y, Suzuki E, Ikenouchi H, Kohmoto O, Kimura K, Kitamura K, Eto T, Kangawa K, Matsuo H, and Omata M. (1995) Mechanisms of adrenomedullin-induced vasodilation in the rat kidney. Hypertension 25:790–795.

    PubMed  Google Scholar 

  • Hono T, Kohno M, Kano H, Ikeda M, Yasunari K, Yokokawa K, Minami M, and Takeda T. (1995) Adrenomedullin as a novel antimigration factor of vascular smooth muscle cells. Cire Res 77:660–664.

    Google Scholar 

  • Hono T, Nishikimi T, Yoshihara F, Matsuo H, Takishita S, and Kangawa K (1999) Effects of adrenomedullin on cultured rat cardiac myocytes and fibroblasts. Eur J Pharmacol 382:1–9.

    Article  PubMed  Google Scholar 

  • Horio T, Nishikimi T, Yoshihara F, Nagaya N, Matsuo H, Takishita S, and Kangawa K. (1998) Production and secretion of adrenomedullin in cultured rat cardiac myocytes and nonmyocytes: stimulation by interleukin-lb and tumor necrosis factor-a. Endocrinology 139:4576–4580.

    Article  PubMed  Google Scholar 

  • Ihara T, Ikeda U, Tate Y, Ishibashi S, and Shimada K. (2000) Positive inotropic effects of adrenomedullin on rat papillary muscle. Eur J Pharmacol 390:167–172.

    Article  PubMed  Google Scholar 

  • Ikenouchi H, Kangawa K, Matsuo H, and Hirata Y (1997) Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytes. Circulation 95:2318–2324.

    PubMed  Google Scholar 

  • Ishiyama Y, Kitamura K, Ichiki Y, Nakamura S, Kida O, Kangawa K, and Eto T. (1993) Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats. Eur J Pharmacol 241:271–273.

    Article  PubMed  Google Scholar 

  • Isumi Y, Kubo A, Katafuchi T, Kangawa K, and Minamino N. (1999) Adrenomedullin suppresses interleukin-lb-induced tumor necrosis factor-a production in Swiss 3T3 cells. FEBS Lett 463:110–114.

    Article  PubMed  Google Scholar 

  • Iwasaki H, Eguchi S, Shichiri M, Marumo F, and Hirata Y. (1998) Adrenomedullin as a novel growth-promoting factor for cultured vascular smooth muscle cells: role of tyrosine kinase-mediated mitogen-activated protein kinase activation. Endocrinology 139:3432–3441.

    Article  PubMed  Google Scholar 

  • Jensen BL, Kramer BK, and Kurtz A. (1997) Adrenomedullin stimulates renin release and renin mRNA in mouse juxtaglomerular granular cells. Hypertension 29:1148–1155.

    PubMed  Google Scholar 

  • Jougasaki M, Aarhus LL, Heublein DM, Sandberg SM, and Bumett JC Jr. (1997) Role of prostaglandins and renal nerves in the renal actions of adrenomedullin. Am J Physiol 272:F260–F266.

    PubMed  Google Scholar 

  • Kamoi H, Kanazawa H, Hirata K, Kurihara N, Yano Y, and Otani S. (1995) Adrenomedullin inhibits the secretion of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, from rat alveolar macrophages. Biochem Biophys Res Commun 211:1031–1035.

    Article  PubMed  Google Scholar 

  • Kanazawa H, Kurihara N, Hirata K, Kudoh S, Kawaguchi T, and Takeda T. (1994) Adrenomedullin, a newly discovered hypotensive peptide, is a potent bronchodilator. Biochem Biophys Res Commun 205:251–254.

    Article  PubMed  Google Scholar 

  • Kano H, Kohno M, Yasunari K, Yokokawa K, Horio T, Ikeda M, Minami M, Hanehira T, Takeda T, and Yoshikawa J. (1996) Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cells. J Hypertens 14:209–213.

    PubMed  Google Scholar 

  • Kapas S, Martinez A, Cuttitta F, and Hinson JP (1998) Local production and action of adrenomedullin in the rat adrenal zona glomerulosa. J Endocrinol 156:477–484.

    Article  PubMed  Google Scholar 

  • Kato H, Shichiri M, Marumo F, Hirata Y (1997) Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells. Endocrinology 138:2615–2620.

    Article  PubMed  Google Scholar 

  • Kawada N and Inoue M. (1994) Effect of adrenomedullin on hepatic pericytes (stellate cells) of the rat. FEBS Lett 356:109–113.

    Article  PubMed  Google Scholar 

  • Kawai J, Ando K, Tojo A, Shimosawa T, Takahashi K, Onozato ML, Yamasaki M, Ogita T, Nakaoka T, and Fujita T. (2004) Endogenous adrenomedullin protects against vascular response to injury in mice. Circulation 109:1147–1153.

    Article  PubMed  Google Scholar 

  • Kim W, Moon SO, Sung MJ, Kim SH, Lee S, So JN, and Park SK. (2003) Angiogenic role of adrenomedullin through activation of Akt, mitogen-activated protein kinase, and focal adhesion kinase in endothelial cells. FASEB J 17:1937–1939.

    PubMed  Google Scholar 

  • Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, and Eto T. (1993) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192:553–560.

    Article  PubMed  Google Scholar 

  • Kohno M, Yokokawa K, Yasunari K, Kano H, Horio T, and Takeda T. (1995) Stimulation of cyclic adenosine monophosphate formation by the novel vasorelaxant peptide adrenomedullin in cultured rat mesangial cells. Metabolism 44:10–12.

    Article  Google Scholar 

  • Lai KN, Leung JC, Yeung VT, Lewis LK, and Nicholls MG. (1998) Gene transcription and synthesis of adrenomedullin by cultured human renal cells. Biochem Biophys Res Commun 244:567–572.

    Article  PubMed  Google Scholar 

  • Lainchbury JG, Troughton RW, Lewis LK, Yandle TG, Richards AM, and Nicholls MG. (2000) Hemodynamic, hormonal, and renal effects of short-term adrenomedullin infusion in healthy volunteers. J Clin Endocrinol Metab 85:1016–1020.

    Article  PubMed  Google Scholar 

  • Lang MG, Patemo R, Faraci FM, and Heistad DD. (1997) Mechanisms of adrenomedullin-induced dilatation of cerebral arterioles. Stroke 28:181–185.

    PubMed  Google Scholar 

  • Leclerc M and Brunette MG. (2000) The paradoxical effect of adrenomedullin on Na+ transport by the renal distal tubule luminal membrane. Mol Cell Endocrinol 164:159–167.

    Article  PubMed  Google Scholar 

  • Lippton H, Chang JK, Hao Q, Summer W, and Hyman AL. (1994) Adrenomedullin dilates the pulmonary vascular bed in vivo. J Appl Physiol 76:2154–2156.

    PubMed  Google Scholar 

  • Lisy O, Jougasaki M, Schirger JA, Chen HH, Barclay PT, and Bumett JC Jr. (1998) Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin. Am J Physiol 275:F410–F414.

    PubMed  Google Scholar 

  • Majid DS, Kadowitz PJ, Coy DH, and Navar LG. (1996) Renal responses to intraarterial administration of adrenomedullin in dogs. Am J Physiol 270:F200–F205.

    PubMed  Google Scholar 

  • Malendowicz LK, Conconi MT, Pamigotto PP, and Nussdorfer GG. (2003) Endogenous adrenomedullin system regulates the growth of rat adrenocortical cells cultured in vitro. Regul Pept 112:27–31.

    Article  PubMed  Google Scholar 

  • Marinoni E, Di Iorio R, Letizia C, Lucchini C, Alo P, and Cosmi EV. (2000) Changes in plasma adrenomedullin levels during the menstrual cycle. Regul Pept 87:15–18.

    Article  PubMed  Google Scholar 

  • Marinoni E, Di Iorio R, Villaccio B, Letizia C, Aragona C, Schimbemi M, and Cosmi EV. (2002) Follicular fluid adrenomedullin concentrations in spontaneous and stimulated cycles: relationship to ovarian function and endothelin-1 and nitric oxide. Regul Pept 107:125–128.

    Article  PubMed  Google Scholar 

  • Martinez A, Weaver C, Lopez J, Bhathena SJ, Elsasser TH, Miller MJ, Moody TW, Unsworth EJ, and Cuttitta F (1996) Regulation of insulin secretion and blood glucose metabolism by adrenomedullin. Endocrinology 137:2626–2632.

    Article  PubMed  Google Scholar 

  • Martinez V, Cuttitta F, and Tache Y. (1997) Central action of adrenomedullin to inhibit gastric emptying in rats. Endocrinology 138:3749–3755.

    Article  PubMed  Google Scholar 

  • Mazzocchi G, Albertin G, Andreis PG, Neri G, Malendowicz LK, Champion HC, Bahcelioglu M, Kadowitz PJ, and Nussdorfer GG. (1999) Distribution, functional role, and signaling mechanism of adrenomedullin receptors in the rat adrenal gland. Peptides 20:1479–1487.

    Article  PubMed  Google Scholar 

  • McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, and Foord SM. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393:333–339.

    Article  PubMed  Google Scholar 

  • Meeran K, O’Shea D, Upton PD, Small CJ, Ghatei MA, Byfield PH, and Bloom SR. (1997) Circulating adrenomedullin does not regulate systemic blood pressure but increases plasma prolactin after intravenous infusion in humans: a pharmacokinetic study. J Clin Endocrinol Metab 82:95–100.

    Article  PubMed  Google Scholar 

  • Michibata H, Mukoyama M, Tanaka I, Suga S, Nakagawa M, Ishibashi R, Goto M, Akaji K, Fujiwara Y, Kiso Y, and Nakao K. (1998) Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells. Kidney Int 53:979–985.

    Article  PubMed  Google Scholar 

  • Miller MJ, Martinez A, Unsworth EJ, Thiele CJ, Moody TW, Elsasser T, and Cuttitta F. (1996) Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor. J Biol Chem 271:23345–51.

    Article  PubMed  Google Scholar 

  • Miyashita K, Itoh H, Sawada N, Fukunaga Y, Sone M, Yamahara K, Yurugi-Kobayashi T, Park K, and Nakao K. (2003) Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo. FEBS Lett 544:86–92.

    Article  PubMed  Google Scholar 

  • Montuenga LM, Martinez A, Miller MJ, Unsworth EJ, and Cuttitta F. (1997) Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action. Endocrinology 138:440–451.

    Article  PubMed  Google Scholar 

  • Moriyama T, Otani T, and Maruo T. (2000) Expression of adrenomedullin by human granulosa lutein cells and its effect on progesterone production. Eur J Endocrinol 142:671–676.

    Article  PubMed  Google Scholar 

  • Mulder H, Ahren B, Karlsson S, and Sundler F (1996) Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion. Regul Pept 62:107–112.

    Article  PubMed  Google Scholar 

  • Murphy TC and Samson WK. (1995) The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat. Endocrinology 136:2459–2463.

    Article  PubMed  Google Scholar 

  • Nagata D, Hirata Y, Suzuki E, Kakoki M, Hayakawa H, Goto A, Ishimitsu T, Minamino N, Ono Y, Kangawa K, Matsuo H, and Omata M. (1999) Hypoxia-induced adrenomedullin production in the kidney. Kidney Int 55:1259–1267.

    Article  PubMed  Google Scholar 

  • Nagaya N, Nishikimi T, Horio T, Yoshihara F, Kanazawa A, Matsuo H, and Kangawa K. (1999) Cardiovascular and renal effects of adrenomedullin in rats with heart failure. Am J Physiol 276:R213–R218.

    PubMed  Google Scholar 

  • Nagaya N, Satoh T, Nishikimi T, Uematsu M, Furuichi S, Sakamaki F, Oya H, Kyotani S, Nakanishi N, Goto Y, Masuda Y, Miyatake K, and Kangawa K. (2000) Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure. Circulation 101:498–503.

    PubMed  Google Scholar 

  • Nakamura Y, Shimatsu A, Murabe H, Mizuta H, Ihara C, and Nakao K. (1998) Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs. Brain Res 807:203–207.

    Article  PubMed  Google Scholar 

  • Nishimatsu H, Suzuki E, Nagata D, Moriyama N, Satonaka H, Walsh K, Sata M, Kangawa K, Matsuo H, Goto A, Kitamura T, and Hirata Y. (2001) Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta. Circ Res 89:63–70.

    PubMed  Google Scholar 

  • Niu P, Shindo T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, and Nagai R (2004) Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage. Circulation (in press)

    Google Scholar 

  • Nuki C, Kawasaki H, Kitamura K, Takenaga M, Kangawa K, Eto T, and Wada A. (1993) Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. Biochem Biophys Res Commun 196:245–251.

    Article  PubMed  Google Scholar 

  • Nussdorfer GG, Rossi GP, and Mazzocchi G (1997) Role of adrenomedullin and related peptides in the regulation of the hypothalamo-pituitary-adrenal axis. Peptides 18:1079–1089.

    Article  PubMed  Google Scholar 

  • Osajima A, Mutoh Y, Uezono Y, Kawamura M, Izumi F, Takasugi M, and Kuroiwa A. (1995) Adrenomedullin increases cyclic AMP more potently than CGRP and amylin in rat renal tubular basolateral membranes. Life Sci 57:457–462.

    Article  PubMed  Google Scholar 

  • Owada A, Nonoguchi H, Terada Y, Marumo F, and Tomita K. (1997) Microlocalization and effects of adrenomedullin in nephron segments and in mesangial cells of the rat. Am J Physiol 272:F691–F697.

    PubMed  Google Scholar 

  • Parameswaran N, Spielman WS, Pullen M, Francis J, Brooks DP, and Nambi P. (1999) Mechanism of adrenomedullin-stimulated hyaluronic acid release in rat mesangial cells. Eur J Pharmacol 370:313–318.

    Article  PubMed  Google Scholar 

  • Parkes DG and May CN (1995) ACTH-suppressive and vasodilator actions of adrenomedullin in conscious sheep. J Neuroendocrinol 7:923–929.

    PubMed  Google Scholar 

  • Petrie MC, Hillier C, Morton JJ, and McMurray JJ. (2000) Adrenomedullin selectively inhibits angiotensin II-induced aldosterone secretion in humans. J Hypertens 18:61–64.

    PubMed  Google Scholar 

  • Rossowski WJ, Jiang NY, and Coy DH. (1997) Adrenomedullin, amylin, calcitonin gene-related peptide and their fragments are potent inhibitors of gastric acid secretion in rats. Eur J Pharmacol 336:51–63.

    Article  PubMed  Google Scholar 

  • Saita M, Shimokawa A, Kunitake T, Kato K, Hanamori T, Kitamura K, Eto T, and Kannan H. (1998) Central actions of adrenomedullin on cardiovascular parameters and sympathetic outflow in conscious rats. Am J Physiol 43:R979–R984.

    Google Scholar 

  • Salomone S, Caruso A, Martinez G, Cutuli VM, Prato A, Bianchi A, Amico-Roxas M, and Clementi G. (2003) Secretory and vascular effects of adrenomedullin in gastric ulcer: role of CGRP-and adrenomedullin-receptors. Peptides 24:1175–1180.

    Article  PubMed  Google Scholar 

  • Samson WK, Murphy T, and Schell DA (1995) A novel vasoactive peptide, adrenomedullin, inhibits pituitary adrenocorticotropin release. Endocrinology 136:2349–2352.

    Article  PubMed  Google Scholar 

  • Serino R, Ueta Y, Hara Y, Nomura M, Yamamoto Y, Shibuya I, Hattori Y, Kitamura K, Kangawa K, Russell JA, and Yamashita H. (1999) Centrally administered adrenomedullin increases plasma oxytocin level with induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of the rat. Endocrinology 140:2334–2342.

    Article  PubMed  Google Scholar 

  • Shan J and Krukoff TL. (2001) Intracerebroventricular adrenomedullin stimulates the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and production of hypothalamic nitric oxide. J Neuroendocrinol 13:975–984.

    Article  PubMed  Google Scholar 

  • Shimekake Y, Nagata K, Ohta S, Kambayashi Y, Teraoka H, Kitamura K, Eto T, Kangawa K, and Matsuo H. (1995) Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+ mobilization, in bovine aortic endothelial cells. J Biol Chem 270:4412–4417.

    Article  PubMed  Google Scholar 

  • Shimosawa T, Shibagaki Y, Ishibashi K, Kitamura K, Kangawa K, Kato S, Ando K, and Fujita T. (2002) Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage. Circulation 105:106–111.

    Article  PubMed  Google Scholar 

  • Stangl V, Dschietzig T, Bramlage P, Boye P, Kinkel HT, Staudt A, Baumann G, Felix SB, and Stangl K. (2000) Adrenomedullin and myocardial conlractility in the rat. Eur J Pharmacol 408:83–89.

    Article  PubMed  Google Scholar 

  • Szokodi I, Kinnunen P, Tavi P, Weckstrom M, Toth M, and Ruskoaho H. (1998) Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide. Circulation 97:1062–1070.

    PubMed  Google Scholar 

  • Takahashi H, Watanabe TX, Nishimura M, Nakanishi T, Sakamoto M, Yoshimura M, Komiyama Y, Masuda M, and Murakami T. (1994) Centrally induced vasopressor and sympathetic responses to a novel endogenous peptide, adrenomedullin, in anesthetized rats. Am J Hypertens 7:478–482.

    PubMed  Google Scholar 

  • Taniyama M, Kitamura K, Ban Y, Sugita E, Ito K, and Katagiri T. (1997) Elevation of circulating proadrenomedullin-N terminal 20-peptide in thyrotoxicosis. Clin Endocrinol (Oxf) 46:271–274.

    Article  Google Scholar 

  • Taylor GM, Meeran K, O’Shea D, Smith DM, Ghatei MA, and Bloom SR. (1996) Adrenomedullin inhibits feeding in the rat by a mechanism involving calcitonin gene-related peptide receptors. Endocrinology 137:3260–3264.

    Article  PubMed  Google Scholar 

  • Tokudome T, Horio T, Yoshihara F, Suga S, Kawano Y, Kohno M, and Kangawa K. (2002) Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism. Endocrinology 143:3515–3521.

    Article  PubMed  Google Scholar 

  • Tsuchida T, Ohnishi H, Tanaka Y, Mine T, and Fujita T. (1999) Inhibition of stimulated amylase secretion by adrenomedullin in rat pancreatic acini. Endocrinology 140:865–870.

    Article  PubMed  Google Scholar 

  • Tsurnda T, Kato J, Kitamura K, Kuwasako K, Imamura T, Koiwaya Y, Tsuji T, Kangawa K, and Eto T. (1998) Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes. Hypertension 31:505–510.

    PubMed  Google Scholar 

  • Wang X, Yue TL, Barone FC, White RF, Clark RK, Willette RN, Sulpizio AC, Aiyar NV, Ruffolo-RR J, and Feuerstein GZ. (1995) Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage. Proc Nati Acad Sci USA 92:11480–11484.

    Google Scholar 

  • Wu R, Zhou M, and Wang P. (2003) Adrenomedullin and adrenomedullin binding protein-1 downregulate TNF-a in macrophage cell line and rat Kupffer cells. Regul Pept 112:19–26.

    Article  PubMed  Google Scholar 

  • Yamaguchi T, Baba K, Doi Y, and Yano K (1995) Effect of adrenomedullin on aldosterone secretion by dispersed rat adrenal zona glomerulosa cells. Life Sci 56:379–387.

    Article  PubMed  Google Scholar 

  • Yamaguchi T, Baba K, Doi Y, Yano K, Kitamura K, and Eto T (1996) Inhibition of aldosterone production by adrenomedullin, a hypotensive peptide, in the rat. Hypertension 28:308–314.

    PubMed  Google Scholar 

  • Yanagita T, Yamamoto R, Sugano T, Kobayashi H, Uezono Y, Yokoo H, Shiraishi S, Minamni SI, and Wada A. (2000) Adrenomedullin inhibits spontaneous and bradykinin-induced but not oxytocin-or prostaglandin F2a-induced periodic contraction of rat uterus. Br J Pharmacol 130:1727–1730.

    Article  PubMed  Google Scholar 

  • Yin H, Chao L, and Chao J. (2004) Adrenomedullin protects against myocardial apoptosis after ischemia/reperfusion through activation of Akt-GSK signaling. Hypertension 43:109–116.

    Article  PubMed  Google Scholar 

  • Yokoi H, Arima H, Murase T, Kondo K, Iwasaki Y, and Oiso Y. (1996) Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats. Neurosci Lett 216:65–67.

    Article  PubMed  Google Scholar 

  • Yoshihara F, Horio T, Nishikimi T, Matsuo H, and Kangawa K. (2002) Possible involvement of oxidative stress in hypoxia-induced adrenomedullin secretion in cultured rat cardiomyocytes. Eur J Pharmacol 436:1–6.

    Article  PubMed  Google Scholar 

  • Yoshihara F, Nishikimi T, Okano I, Horio T, Yutani C, Matsuo H, Takishita S, Ohe T, and Kangawa K. (2001) Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats. Hypertension 37:216–222.

    PubMed  Google Scholar 

  • Yoshimoto R, MitsuiSaito M, Ozaki H, and Karaki H. (1998) Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery. Br J Pharmacol 123:1645–1654.

    Article  PubMed  Google Scholar 

  • Zhao Y, Hague S, Manek S, Zhang L, Bicknell R, and Rees MCP. (1998) PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium. Oncogene 16:409–415.

    Article  PubMed  Google Scholar 

  • Ziolkowska A, Budzynska K, Trejter M, Tortorella C, Belloni AS, and Malendowicz LK. (2003) Effects of adrenomedullin and its fragment 22–52 on basal and ACTH-stimulated secretion of cultured rat adrenocortical cells. Int J Mol Med 11:613–615.

    PubMed  Google Scholar 

  • Zudaire E, Cuttitta F, and Martinez A. (2003a) Regulation of pancreatic physiology by adrenomedullin and its binding protein. Regul Pept 112:121–130.

    Article  PubMed  Google Scholar 

  • Zudaire E, Martinez A, and Cuttitta F. (2003b) Adrenomedullin and cancer. Regul Pept 112:175–183.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, National Cardiovascular Cente, Osaka, Japan

    Takeshi Horio & Fumiki Yoshihara

Authors
  1. Takeshi Horio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fumiki Yoshihara
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan

    Toshio Nishikimi MD, PhD

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Horio, T., Yoshihara, F. (2005). Biological Action of Adrenomedullin. In: Nishikimi, T. (eds) Adrenomedullin in Cardiovascular Disease. Basic Science for the Cardiologist, vol 19. Springer, Boston, MA. https://doi.org/10.1007/0-387-25405-6_5

Download citation

  • DOI: https://doi.org/10.1007/0-387-25405-6_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25404-3

  • Online ISBN: 978-0-387-25405-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation