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The FYVE Finger: A Phosphoinositide Binding Domain

  • Chapter
Zinc Finger Proteins

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The FYVE finger is an evolutionarily conserved double-zinc binding domain with structural similarity to RING and PHD fingers. It consists of two β-hairpins that are stabilized by a C-terminal α-helix and the coordination of two Zn2+ ions. The most characteristic feature of the FYVE finger is a R(R/K)HHCR motif associated with the first β-strand. This motif mediates coordination of the ligand, phosphatidylinositol 3-phosphate (PI3P), via contacts with the phosphate and inositol hydroxyl groups of PI3P. PI3P, a rare lipid formed on endosomes and phagosomes by phosphorylation of phosphatidylinositol, is crucial for phagosome maturation and endocytic trafficking; and FYVE finger proteins are important effectors of PI3P as it has been shown that several FYVE finger proteins among the 27 human proteins play central roles in endocytic and phagocytic membrane trafficking.

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Authors and Affiliations

  1. Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway

    Harald Stenmark

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  1. Harald Stenmark
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Editors and Affiliations

  1. Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA

    Shiro Iuchi

  2. Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Natalie Kuldell

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Stenmark, H. (2005). The FYVE Finger: A Phosphoinositide Binding Domain. In: Iuchi, S., Kuldell, N. (eds) Zinc Finger Proteins. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27421-9_19

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