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Microbial Production of Recombinant Human Insulin

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The ABCs of Gene Cloning
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Abstract

The early success of recombinant DNA technology relies heavily on the elucidation of the biological possesses at the molecular level in microbial systems. The first commercial application is realized in the microbial production of human insulin.

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Chapter 16: Microbial Production of Recombinant Human Insulin

  • Atkinson, M. A., and Maclaren, N. K. 1990. What causes diabetes? Sci. Am. 263(1), 62–71.

    PubMed  CAS  Google Scholar 

  • Bristow, A. F. 1993. Recombinant-DNA-derived insulin analogues as potentially useful therapeutic agents. Trends Biotechnol. 11, 301–305.

    Article  PubMed  CAS  Google Scholar 

  • Gilbert, W., and Willa-Komaroff, L. 1980. Useful proteins from recombinant bacteria. Sci. Am. 242(4), 74–94.

    PubMed  CAS  Google Scholar 

  • Goeddel, D. V., Kleid, D. G., Bolivar, F., Heyneker, H. L., Yansura, D. G., Crea, R., Hirose, T., Kraszewski, A., Itakura, K., and Riggs, A. D. 1979. Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc. Natl. Acad. Sci. USA 76, 106–110.

    Article  PubMed  CAS  Google Scholar 

  • Lienhard, G. E., Slot, J. S., James, D. E., and Mueckler, M. M. 1992. How cells absorb glucose? Sci. Am. 266(1), 86–91.

    Article  PubMed  CAS  Google Scholar 

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© 2006 Springer Science+Business Media, Inc.

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(2006). Microbial Production of Recombinant Human Insulin. In: The ABCs of Gene Cloning. Springer, Boston, MA. https://doi.org/10.1007/0-387-28679-9_16

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