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NF-κB in Neurons

Behavioral and Physiologic Roles in Nervous System Function

  • Chapter
NF-κB/Rel Transcription Factor Family

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Summary

The neuronal NF-κB signaling system represents a novel and potentially vital component involved in linking activity at the synapse to activity within the nucleus. NF-κB was the first transcription factor to be localized to the synapse. Since its initial characterization in the nervous system, NF-κB has been shown to be regulated by a variety of stimuli, suggesting that it may play a role in integration of numerous different types of information within the nervous system. Ample evidence exists demonstrating that NF-κB factors are engaged in and are necessary for formation of synaptic plasticity and long-term memory. Even though we are only beginning to understand the contribution of distinct NF-κB family members to the regulation of gene transcription in the brain, all of the evidence collected thus far indicates that NF-κB may represent a vital part of the molecular machinery involved in mammalian cognition.

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Authors and Affiliations

  1. Department of Neuroscience, Baylor College of Medicine, Houston, Texas, 77030, USA

    Jonathan M. Levenson & J. David Sweatt

  2. Department of Pharmacology The Waisman Center for Human Development, University of Wisconsin Medical School, Madison, Wisconsin, USA

    Jonathan M. Levenson

  3. Division of Pharmacology and Experimental Therapeutics Department of Biomedical Sciences and Biotechnologies School of Medicine, University of Brescia, Brescia, Italy

    Marina Pizzi

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  1. Jonathan M. Levenson
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  2. Marina Pizzi
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  3. J. David Sweatt
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Correspondence to Jonathan M. Levenson .

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Editors and Affiliations

  1. Division of Immunology, Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA

    Hsiou-Chi Liou Ph.D.

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Levenson, J.M., Pizzi, M., Sweatt, J.D. (2006). NF-κB in Neurons. In: Liou, HC. (eds) NF-κB/Rel Transcription Factor Family. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-33573-0_11

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