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Selenoproteins and selenoproteomes

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Selenium

Summary

In the past several years, progress in genome sequencing and development of specialized bioinformatics tools allowed efficient identification of selenocysteine-containing proteins encoded in completely sequenced genomes. Information is currently available on selenoproteomes from a variety of organisms, including humans, which contain 25 known selenoprotein genes. This review provides basic information about mammalian selenoproteins and other known selenoprotein families. Analysis of full sets of selenoproteins in organisms provides exciting avenues for examining selenoprotein evolution and dependence of organisms on the trace element selenium and allows linking selenoproteins with specific biological and biomedical effects of dietary selenium.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Nebraska, Lincoln, NE, 68688, USA

    Vadim N. Gladyshev

Authors
  1. Vadim N. Gladyshev
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Editor information

Editors and Affiliations

  1. National Cancer Institute, USA

    Dolph L. Hatfield

  2. University of Hawaii, USA

    Marla J. Berry

  3. Univeristy of Nebraska, USA

    Vadim N. Gladyshev

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© 2006 Springer Science+Business Media, LLC

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Gladyshev, V.N. (2006). Selenoproteins and selenoproteomes. In: Hatfield, D.L., Berry, M.J., Gladyshev, V.N. (eds) Selenium. Springer, Boston, MA. https://doi.org/10.1007/0-387-33827-6_9

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