Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
KoƧ ON, Gerson S, Cooper B, et al. Rapid hematopoietic recovery after co-infusion of autologous culture-expanded human mesenchymal stem cells (hMSCs) and PBPCs in breast cancer patients receiving high dose chemotherapy. J Clin Oncol. 2000:18:307ā316.
Lennon DP, Haynesworth SE, Bruder SP, Jaiswal N, Caplan AI. Development of a serum screen for mesenchymal progenitor cells from bone marrow. In Vitro Cell Dev Biol. 1996;32:602ā611.
Galotto M, Berisso G, Delfino L, et al. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol. 1999;27:1460ā1466.
Barbot C, Rice A, Vanes I, Mahon FX, Jazwiec B, Reiffers J. Quality and functional capacity of the bone marrow microenvironment of autologous blood stem cell transplantation recipients. Nouv Rev Fr Hematol. 1994;36:325ā331.
Fried W, Kedo A, Barone J. Effects of cyclophosaphamide and of busulfan on spleen colony-forming units and on hematopoietic stroma. Cancer Res. 1977;37:1205ā1209.
McManus PM, Weiss L. Busulfan-induced chronic bone marrow failure: changes in cortical bone, marrow stromal cells, and adherent cell colonies. Blood. 1984;64:1036ā1041.
Uhlman DL, Verfaillie C, Jones RB, Luikart SD. BCNU treatment of marrow stromal monolayers reversibly alters haematopoiesis. Br J Haematol. 1991;78:3304ā3309.
Toksoz D, Zsebo K, Smith K, et al. Support of human hematopoiesis in long term bone marrow cultures by murine stromal cells selectively expressing the membrane bound and secreted forms of the human homologue of the steel gene product, stem cell factor. Proc Natl Acad Sci USA. 1992;89:7350ā7354.
Clark B, Keating A. Biology of bone marrow stroma. Ann NY Acad Sci. 1995;770:70ā88.
Haynesworth S, Baber M, Caplan A. Cytokine expression by human marrow derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1a. J Cell Physiol. 1996;166:585ā592.
Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol. 1998;176:186ā192.
Majumdar M, Thiede M, Haynesworth S, Bruder S, Gerson S. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res. 2001;9:841ā848.
Kadereit S, Deeds L, Haynesworth S, et al. Mesencymal stem cell as a feeder layer during short-term umbilical cord blood in vivo expansion increases early hematopoietic progenitors. Stem Cells. 2002;20:573ā582.
Klyushnenkova E, Mosca J, McIntosh K. Human mesenchymal stem cells suppress allogeneic T cell responses in vitro: implications for allogeneic transplantation. Blood. 1998;92:642a.
Di Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood. 2002;99:3838ā3843.
LeBlanc K, Tammik L, Sundberg B, Haynesworth S, Ringden O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scan J Immunol. 2003;57:11ā20.
Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation. 2003;75:389ā397.
Maitra B, Szekely E, Gjini K, Laughlin MJD, Haynesworth S, KoƧ ON. Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transplant. 2003.
Farida D, Pascale P, Claire B, et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood. 2003.
Krampera M, Glennie S, Dyson J, et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood. 2003;101:3722ā3729.
Anklesaria P, Kase K, Glowacki J, et al. Engraftment of a clonal bone marrow stromal cell line in vivo stimulates hematopoietic recovery from total body irradiation. Proc Natl Acad Sci USA. 1987;1987:7681ā7685.
Almeida-Porada G, Flake A, Hudson A, Zanjani E. Co transplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero. Exp Hematol. 1999;27:1569ā1575.
Noort WA, Kruisselbrink AB, Anker PS, et al. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol. 2002;30:870ā878.
Angelopoulou M, Novelli E, Grove J, et al. Co transplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Exp Hematol. 2003;31:413ā420.
Almeida-Porada G, Porada C, Tran N, Zanjani E. Co transplantation of human stromal cell progenitors into preimmune ftal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation. Blood. 2000;95:3620ā3627.
Ishida T, Inaba M, Hisha H, et al. Requirement of donor-derived stromal cells in the bone marrow for successful allogeneic bone marrow transplantation. Complete prevention of recurrence of autoimmune diseases in MRL/MP-Ipr/Ipr mice by transplantation of bone marrow plus bones (stromal cells) from the same donor. J Immunol. 1994;152:3119ā3127.
El-Badri N, Wang BC, Good R. Osteoblasts promote engraftment of allogeneic hematopoietic stem cells. Exp Hematol. 1998;29:110ā116.
Kaufman C, Colson Y, Wren S, Watkins S, Simmons R, Ildstad S. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood. 1994;84:2436ā2446.
Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol. 2002;72:1653ā1655.
Simmons PJ, Przepiorka D, Thomas ED, Torok-Storb B. Host origin of marrow stromal cells following allogeneic bone marrow transplantation. Nature. 1987;328:429ā432.
KoƧ ON, Peters C, Raghavan S, et al. Bone marrow derived mesenchymal stem cells of patients with lysosomal and peroxisomal storage diseases remain host type following allogeneic bone marrow transplantation. Exp Hematol. 1999;27:1675ā1681.
Horwitz EM, Prockop DJ, Fitzpatrick LA, et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med. 1999;5:309ā313.
Rombouts W, Ploemacher R. Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture. Leukemia. 2003;17:160ā170.
Mackenzie T, Flake A. Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep. Blood Cells Mol Dis. 2001;27:601ā604.
Lazarus H, Haynesworth S, Gerson S, Rosenthal N, Caplan A. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therpeutic use. Bone Marrow Transplant. 1995;16:557ā564.
KoƧ ON, Day J, Nieder M, Gerson S, Lazarus H, Krivit W. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant. 2002;30:215ā222.
Lazarus H, Curtin P, Devine S, McCarthy P, Holland K, Moseley AAB. Role of mesenchymal stem cells in allogeneic transplantation: early phase I clinical results. Blood. 2000;96:392a.
Horwitz E, Gordon P, Koo W, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci USA. 2002;99:8932ā8937.
Lee S, Jang J, Cheong J, et al. Treatment of high-risk acute myelogenous leukaemia by myeloablative chemoradiotherapy followed by co-infusion of T cell-depleted haematopoietic stem cells and culture-expanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leucocyte antigen haplotype. Br J Haematol. 2001;118:1128ā1131.
MacMillan L, Ramsay N, Atkinson K, Wagner J. Ex vivo culture-expanded parental haploidentical mesenchymal stem cells promote engraftment in recipients of unrelated donor umbilical cord blood: results of a phase I-II clinical trial. Blood. 2002;100:836a.
Krivit W, Day J, Koc ON, Atkinson K. Multiple mesenchymal stem cell (allogen) infusions in patients with metachromatic leukodystrophy: safety of infusions and stability of nerve conduction velocities. Blood. 2002;100:524a.
Cahill R, Jones O, Mueller T, El-Badri N, Good R. Replacement of recipient stromal/mesenchymal cells after bone marrow transplant using bone fragments and cultured osteoblast like cells. Blood. 2002;100:63a.
Frassoni F, Labopin M, Bacigalupo A, et al. Expanded mesenchymal stem cells (MSC), co-infused with HLA identical hemopoietic stem cell transplants, reduce acute and chronic graft versus host disease: a matched pair analysis. Bone Marrow Transplant. 2002;29:S2.
Laughlin MJ, Barker J, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001;344:1815ā1822.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
Ā© 2006 Springer
About this chapter
Cite this chapter
KoƧ, O.N. (2006). Clinical Trials of Human Mesenchymal Stem Cells to Support Hematopoietic Stem Cell Transplantation. In: Nolta, J.A. (eds) Genetic Engineering of Mesenchymal Stem Cells. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3959-X_9
Download citation
DOI: https://doi.org/10.1007/1-4020-3959-X_9
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-3935-5
Online ISBN: 978-1-4020-3959-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)