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The P53 Pathway: Targets for the Development of Novel Cancer Therapeutics

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Molecular Targeting and Signal Transduction

Part of the book series: Cancer Treatment and Research ((CTAR,volume 119))

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References

  1. Lane, D.P. & Crawford, L.V. (1979). Nature, 278, 261–3.

    Article  CAS  PubMed  Google Scholar 

  2. Linzer, D.I. & Levine, A.J. (1979). Cell, 17, 43–52.

    Article  CAS  PubMed  Google Scholar 

  3. Lane, D.P. & Benchimol, S. (1990). Genes Dev, 4, 1–8.

    CAS  PubMed  Google Scholar 

  4. Santibanez-Koref, M.F., Birch, J.M., Hartley, A.L., Jones, P.H., Craft, A.W., Eden, T., Crowther, D., Kelsey, A.M. & Harris, M. (1991). Lancet, 338, 1490–1.

    CAS  PubMed  Google Scholar 

  5. Varley, J.M. (2003). Hum Mutat, 21, 313–20.

    CAS  PubMed  Google Scholar 

  6. Vogelstein, B. & Kinzler, K.W. (1992). Cell, 70, 523–6.

    Article  CAS  PubMed  Google Scholar 

  7. Velculescu, V.E. & El-Deiry, W.S. (1996). Clin Chem, 42, 858–68.

    CAS  PubMed  Google Scholar 

  8. Vogelstein, B., Lane, D. & Levine, A.J. (2000). Nature, 408, 307–10.

    Article  CAS  PubMed  Google Scholar 

  9. Zhao, R., Gish, K., Murphy, M., Yin, Y, Notterman, D., Hoffman, W.H., Tom, E., Mack, D.H. & Levine, A.J. (2000). Genes Dev, 14, 981–93.

    Article  CAS  PubMed  Google Scholar 

  10. El-Deiry, W.S. (2001). Cell Death Differ, 8, 1066–75.

    Article  CAS  PubMed  Google Scholar 

  11. Vousden, K.H. (2000). Cell, 103, 691–4.

    Article  CAS  PubMed  Google Scholar 

  12. Sax, J.K. & El-Deiry, W.S. (2003). Cell Death Differ, 10, 413–7.

    Article  CAS  PubMed  Google Scholar 

  13. El-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W. & Vogelstein, B. (1993). Cell, 75, 817–25.

    Article  CAS  PubMed  Google Scholar 

  14. Burns, T.F. & el-Deiry, W.S. (2003). Cancer Treat Res, 115, 319–43.

    CAS  PubMed  Google Scholar 

  15. Burns, T.F., Bernhard, E.J. & El-Deiry, W.S. (2001). Oncogene, 20, 4601–12.

    Article  CAS  PubMed  Google Scholar 

  16. Fei, P., Bernhard, E.J. & El-Deiry, W.S. (2002). Cancer Res, 62, 7316–27.

    CAS  PubMed  Google Scholar 

  17. Oren, M., Damalas, A., Gottlieb, T, Michael, D., Taplick, J., Leal, J.F., Maya, R., Moas, M., Seger, R., Taya, Y. & Ben-Ze’ev, A. (2002). Biochem Pharmacol, 64, 865–71

    Article  CAS  PubMed  Google Scholar 

  18. Kaghad, M., Bonnet, H., Yang, A., Creancier, L., Biscan, J.C., Valent, A., Minty, A., Chalon, P., Lelias, J.M., Dumont, X., Ferrara, P., McKeon, F. & Caput, D. (1997). Cell, 90, 809–19.

    Article  CAS  PubMed  Google Scholar 

  19. Yang, A., Kaghad, M., Wang, Y, Gillett, E., Fleming, M.D., Dotsch, V., Andrews, N.C., Caput, D. & McKeon, F. (1998). Mol Cell, 2, 305–16.

    Article  CAS  PubMed  Google Scholar 

  20. Senoo, M, Seki, N., Ohira, M., Sugano, S., Watanabe, M., Inuzuka, S., Okamoto, T., Tachibana, M., Tanaka, T., Shinkai, Y. & Kato, H. (1998). Biochem Biophys Res Commun, 248, 603–7.

    Article  CAS  PubMed  Google Scholar 

  21. Trink, B., Okami, K., Wu, L., Sriuranpong, V., Jen, J. & Sidransky, D. (1998). Nat Med, 4, 747–8.

    Article  PubMed  Google Scholar 

  22. Benard, J., Douc-Rasy, S. & Ahomadegbe, J.C. (2003). Hum Mutat, 21, 182–91.

    CAS  PubMed  Google Scholar 

  23. Kaelin, W.G., Jr. (1999). Oncogene, 18, 7701–5.

    Article  CAS  PubMed  Google Scholar 

  24. Yang, A. & McKeon, F. (2000). Nat Rev Mol Cell Biol, 1, 199–207.

    Article  CAS  PubMed  Google Scholar 

  25. Flores, E.R., Tsai, K.Y., Crowley, D., Sengupta, S., Yang, A., McKeon, F. & Jacks, T. (2002). Nature, 416, 560–4.

    Article  CAS  PubMed  Google Scholar 

  26. Bergamaschi, D., Samuels, Y, O’Neil, N.J., Trigiante, G., Crook, T., Hsieh, J.K., O’Connor, D.J., Zhong, S., Campargue, I., Tomlinson, M.L., Kuwabara, P.E. & Lu, X. (2003). Nat Genet, 33, 162–7.

    Article  CAS  PubMed  Google Scholar 

  27. Freeman, D.J., Li, A.G., Wei, G., Li, H.H., Kertesz, N., Lesche, R., Whale, A.D., Martinez-Diaz, H., Rozengurt, N., Cardiff, R.D., Liu, X. & Wu, H. (2003). Cancer Cell, 3, 117–30.

    Article  CAS  PubMed  Google Scholar 

  28. MacLachlan, T.K. & El-Deiry, W.S. (2002). Proc Natl Acad Sci U S A, 99, 9492–7.

    Article  CAS  PubMed  Google Scholar 

  29. Slee, E.A. & Lu, X. (2003). Toxicol Lett, 139, 81–7.

    Article  CAS  PubMed  Google Scholar 

  30. Bergamaschi, D., Gasco, M., Hiller, L., Sullivan, A., Syed, N., Trigiante, G., Yulug, I., Merlano, M., Numico, G., Comino, A., Attard, M., Reelfs, O., Gusterson, B., Bell, A.K., Heath, V., Tavassoli, M., Farrell, P.J., Smith, P., Lu, X. & Crook, T. (2003). Cancer Cell, 3, 387–402.

    Article  CAS  PubMed  Google Scholar 

  31. Irwin, M.S., Kondo, K., Marin, M.C., Cheng, L.S., Hahn, W.C. & Kaelin, W.G. (2003). Cancer Cell, 3, 403–10.

    Article  CAS  PubMed  Google Scholar 

  32. Melino, G., De Laurenzi, V. & Vousden, K.H. (2002). Nat Rev Cancer, 2, 605–15.

    Article  CAS  PubMed  Google Scholar 

  33. Moll, U.M., LaQuaglia, M., Benard, J. & Riou, G. (1995). Proc Natl Acad Sci U S A, 92, 4407–11.

    CAS  PubMed  Google Scholar 

  34. Hibi, K., Trink, B., Patturajan, M., Westra, W.H., Caballero, O.L., Hill, D.E., Ratovitski, E.A., Jen, J. & Sidransky, D. (2000). Proc Natl Acad Sci U S A, 97, 5462–7.

    Article  CAS  PubMed  Google Scholar 

  35. Vousden, K.H. & Lu, X. (2002). Nat Rev Cancer, 2, 594–604.

    Article  CAS  PubMed  Google Scholar 

  36. Kubbutat, M.H., Jones, S.N. & Vousden, K.H. (1997). Nature, 387, 299–303.

    Article  CAS  PubMed  Google Scholar 

  37. Wu, X., Bayle, J.H., Olson, D. & Levine, A.J. (1993). Genes Dev, 7, 1126–32.

    CAS  PubMed  Google Scholar 

  38. Grossman, S.R., Perez, M., Kung, A.L., Joseph, M., Mansur, C., Xiao, Z.X., Kumar, S., Howley, P.M. & Livingston, D.M. (1998). Mol Cell, 2, 405–15.

    Article  CAS  PubMed  Google Scholar 

  39. Oliner, J.D., Pietenpol, J.A., Thiagalingam, S., Gyuris, J., Kinzler, K.W. & Vogelstein, B. (1993). Nature, 362, 857–60.

    Article  CAS  PubMed  Google Scholar 

  40. Haupt, Y., Maya, R., Kazaz, A. & Oren, M. (1997). Nature, 387, 296–9.

    Article  CAS  PubMed  Google Scholar 

  41. Grossman, S.R., Deato, M.E., Brignone, C., Chan, H.M., Kung, A.L., Tagami, H., Nakatani, Y. & Livingston, D.M. (2003). Science, 300, 342–4.

    Article  CAS  PubMed  Google Scholar 

  42. Mayo, L.D. & Donner, D.B. (2001). Proc Natl Acad Sci U S A, 98, 11598–603.

    Article  CAS  PubMed  Google Scholar 

  43. Zhou, B.P., Liao, Y., Xia, W., Zou, Y., Spohn, B. & Hung, M.C. (2001). Nat Cell Biol, 3, 973–82.

    CAS  PubMed  Google Scholar 

  44. Sabbatini, P. & McCormick, F. (1999). J Biol Chem, 274, 24263–9.

    Article  CAS  PubMed  Google Scholar 

  45. Basu, S., Totty, N.F., Irwin, M.S., Sudol, M. & Downward, J. (2003). Mol Cell, 11, 11–23.

    Article  CAS  PubMed  Google Scholar 

  46. Broome, M.A. & Courtneidge, S.A. (2000). Oncogene, 19, 2867–9.

    Article  CAS  PubMed  Google Scholar 

  47. Schreiber, M., Kolbus, A., Piu, R, Szabowski, A., Mohle-Steinlein, U., Tian, J., Karin, M., Angel, P. & Wagner, E.F. (1999). Genes Dev, 13, 607–19.

    CAS  PubMed  Google Scholar 

  48. Leng, R.P., Lin, Y, Ma, W., Wu, H., Lemmers, B., Chung, S., Parant, J.M., Lozano, G., Hakem, R. & Benchimol, S. (2003). Cell, 112, 779–91.

    Article  CAS  PubMed  Google Scholar 

  49. Woods, D.B. & Vousden, K.H. (2001). Exp Cell Res, 264, 56–66.

    Article  CAS  PubMed  Google Scholar 

  50. Bakkenist, C.J. & Kastan, M.B. (2003). Nature, 421, 499–506.

    Article  CAS  PubMed  Google Scholar 

  51. Ashcroft, M., Taya, Y. & Vousden, K.H. (2000) Mol Cell Biol, 20, 3224–33.

    Article  CAS  PubMed  Google Scholar 

  52. Brooks, C.L. & Gu, W. (2003). Curr Opin Cell Biol, 15, 164–71.

    Article  CAS  PubMed  Google Scholar 

  53. Blagosklonny, M.V. & el-Deiry, W.S. (1996). Int J Cancer, 67, 386–92.

    Article  CAS  PubMed  Google Scholar 

  54. Blagosklonny, M.V. & El-Deiry, W.S. (1998). Int J Cancer, 75, 933–40.

    Article  CAS  PubMed  Google Scholar 

  55. Wu, G.S. & El-Deiry, W.S. (1996). Clin Cancer Res, 2, 623–33.

    CAS  PubMed  Google Scholar 

  56. Chen, J., Willingham, T., Shuford, M., Bruce, D., Rushing, E., Smith, Y. & Nisen, P.D. (1996). Oncogene, 13, 1395–403.

    CAS  PubMed  Google Scholar 

  57. Kaeser, M.D. & Iggo, R.D. (2002). Proc Natl Acad Sci U S A, 99, 95–100.

    Article  CAS  PubMed  Google Scholar 

  58. Szak, ST., Mays, D. & Pietenpol, J.A. (2001). Mol Cell Biol, 21, 3375–86.

    Article  CAS  PubMed  Google Scholar 

  59. Samuels-Lev, Y., O’Connor, D.J., Bergamaschi, D., Trigiante, G., Hsieh, J.K., Zhong, S., Campargue, I., Naumovski, L., Crook, T. & Lu, X. (2001). Mol Cell, 8, 781–94.

    Article  CAS  PubMed  Google Scholar 

  60. Komarova, E.A., Christov, K., Faerman, A.I. & Gudkov, A.V. (2000). Oncogene, 19, 3791–8.

    Article  CAS  PubMed  Google Scholar 

  61. Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A. & Jacks, T. (1993). Nature, 362, 847–9.

    Article  CAS  PubMed  Google Scholar 

  62. Clayman, G.L., el-Naggar, A.K., Roth, J.A., Zhang, W.W., Goepfert, H., Taylor, D.L. & Liu, T.J. (1995). Cancer Res, 55, 1–6.

    CAS  PubMed  Google Scholar 

  63. Nishizaki, M., Meyn, R.E., Levy, L.B., Atkinson, E.N., White, R.A., Roth, J.A. & Ji, L. (2001) Clin Cancer Res, 7, 2887–97.

    CAS  PubMed  Google Scholar 

  64. Hamid, O., Varterasian, M.L., Wadler, S., Hecht, J.R., Benson, A., 3rd, Galanis, E., Uprichard, M., Omer, C., Bycott, P., Hackman, R.C. & Shields, A.F. (2003) J Clin Oncol, 21, 1498–504.

    Article  CAS  PubMed  Google Scholar 

  65. Hecht, J.R., Bedford, R., Abbruzzese, J.L., Lahoti, S., Reid, T.R., Soetikno, R.M., Kirn, D.H. & Freeman, S.M. (2003) Clin Cancer Res, 9, 555–61.

    CAS  PubMed  Google Scholar 

  66. Komarov, P.G., Komarova, E.A., Kondratov, R.V., Christov-Tselkov, K., Coon, J.S., Chernov, M.V. & Gudkov, A.V. (1999) Science, 285, 1733–7.

    Article  CAS  PubMed  Google Scholar 

  67. Foster, B.A., Coffey, H.A., Morin, M.J. & Rastinejad, F. (1999) Science, 286, 2507–10.

    Article  CAS  PubMed  Google Scholar 

  68. Takimoto, R., Wang, W., Dicker, D.T., Rastinejad, F., Lyssikatos, J. & el-Deiry, W.S. (2002) Cancer Biol Ther, 1, 47–55.

    CAS  PubMed  Google Scholar 

  69. Wang, W., Takimoto, R., Rastinejad, F. & El-Deiry, W.S. (2003) Mol Cell Biol, 23, 2171–81.

    CAS  PubMed  Google Scholar 

  70. Bykov, V.J., Issaeva, N., Selivanova, G. & Wiman, K.G. (2002) Carcinogenesis, 23, 2011–8.

    Article  CAS  PubMed  Google Scholar 

  71. Peng, Y, Li, C., Chen, L, Sebti, S. & Chen, J. (2003) Oncogene, 22, 4478–87.

    Article  CAS  PubMed  Google Scholar 

  72. Friedler, A., Hansson, L.O., Veprintsev, D.B., Freund, S.M., Rippin, T.M., Nikolova, P.V., Proctor, M.R., Rudiger, S. & Fersht, A.R. (2002) Proc Natl Acad Sci U S A, 99, 937–42.

    Article  CAS  PubMed  Google Scholar 

  73. Sohn, T.A., Bansal, R., Su, G.H., Murphy, K.M. & Kern, S.E. (2002). Carcinogenesis, 23, 949–57.

    Article  CAS  PubMed  Google Scholar 

  74. Sax, J.K., Fei, P., Murphy, M.E., Bernhard, E., Korsmeyer, S.J. & El-Deiry, W.S. (2002). Nat Cell Biol, 4, 842–9.

    Article  CAS  PubMed  Google Scholar 

  75. Chene, P. (2003). Expert Opin Ther Targets, 7, 453–61.

    Article  CAS  PubMed  Google Scholar 

  76. Bottger, A., Bottger, V., Sparks, A., Liu, W.L., Howard, S.F. & Lane, D.P. (1997). Curr Biol, 7, 860–9.

    Article  CAS  PubMed  Google Scholar 

  77. Bottger, V., Bottger, A., Howard, S.F., Picksley, S.M., Chene, P., Garcia-Echeverria, C., Hochkeppel, H.K. & Lane, D.P. (1996). Oncogene, 13, 2141–7.

    CAS  PubMed  Google Scholar 

  78. Midgley, C.A., Desterro, J.M., Saville, M.K., Howard, S., Sparks, A., Hay, R.T. & Lane, D.P. (2000). Oncogene, 19, 2312–23.

    Article  CAS  PubMed  Google Scholar 

  79. Donehower, L.A. (1996). Semin Cancer Biol, 7, 269–78

    Article  CAS  PubMed  Google Scholar 

  80. Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A., Jr., Butel, J.S. & Bradley, A. (1992). Nature, 356, 215–21.

    Article  CAS  PubMed  Google Scholar 

  81. Jacks, T, Remington, L., Williams, B.O., Schmitt, E.M., Halachmi, S., Bronson, R.T. & Weinberg, R.A. (1994). Curr Biol, 4, 1–7.

    Article  CAS  PubMed  Google Scholar 

  82. Roth, J., Dobbelstein, M., Freedman, D.A., Shenk, T. & Levine, A.J. (1998). Embo J, 17, 554–64.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Departments of Medicine, Genetics, Pharmacology, and Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania

    Shulin Wang & Wafik S. El-Deiry

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  1. Shulin Wang
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Editors and Affiliations

  1. M. D. Anderson Cancer Center, The University of Texas, Houston, TX, USA

    Rakesh Kumar Ph.D.

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Wang, S., El-Deiry, W.S. (2004). The P53 Pathway: Targets for the Development of Novel Cancer Therapeutics. In: Kumar, R. (eds) Molecular Targeting and Signal Transduction. Cancer Treatment and Research, vol 119. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7847-1_9

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  • DOI: https://doi.org/10.1007/1-4020-7847-1_9

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