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Epidemiology and Zoonotic Potential of Giardia Infections

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The Pathogenic Enteric Protozoa: Giardia, Entamoeba, Cryptosporidium and Cyclospora

Part of the book series: World Class Parasites ((WCPA,volume 8))

Abstract

Determining the source of infection is central to an understanding of the epidemiology of giardiasis. In this respect, the role of zoonotic transmission has been a matter of controversy for many years. This has been complicated by the fact that the causative agent of giardiasis, Giardia duodenalis, is a common parasite of people, domestic animals and wildlife. The development and application of molecular epidemiological tools has now made it possible to directly genotype Giardia isolated from animals and environmental samples. These studies have shown that many species of mammals are susceptible to infection with zoonotic and host-adapted genotypes of G. duodenalis and that they are often present in the same endemic foci. Recent studies have also demonstrated that zoonotic transmission does occur in nature. However, available data suggests that zoonotic transmission does not appear to play a major role in waterborne outbreaks of giardiasis. More studies are required on the molecular epidemiology of Giardia infections in order to more accurately determine the frequency of zoonotic transmission in localised endemic foci and in outbreak situations.

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References

  • Abe, N., Kimata I., and Iseki M. 2003. Identification of genotypes of Giardia intestinalis isolates from dogs in Japan by direct sequencing of the PCR amplified glutamate dehydrogenase gene. Journal of Veterinary Medicine and Science 61: 29–33.

    Google Scholar 

  • Appelbee, A., Thorlakson, C., and Olson, M.E. 2002. Genotypic characterization of Giardia cysts isolated from wild beaver in southern Alberta, Canada. In: Olson, B.E., Olson, M.E., Wallis, P.M. (Eds.), Giardia: The cosmopolitan parasite. CAB International, Wallingford, UK, pp 299–300.

    Google Scholar 

  • Appelbee, A.J., Frederick, L.M., Heitman, T.L. and Olson M.E. 2003. Prevalence and genotyping of Giardia duodenalis from beef calves in Alberta, Canada. Veterinary Parasitology 112: 289–294.

    Article  CAS  PubMed  Google Scholar 

  • Andrews, R.H., Adams, M. and Boreham. P.F.L. et al. 1989. Giardia intestinalis: electrophoretic evidence for a species complex. International Journal for Parasitology 19: 183–190.

    CAS  PubMed  Google Scholar 

  • Bemrick, W.J. and Erlandsen, S.L. 1988. Giardiasis — is it really a zoonosis? Parasitology Today 4: 69–71.

    Article  CAS  PubMed  Google Scholar 

  • Bugg, R.J., Robertson, I.D., Elliot, A.D. and Thompson, R.C.A. 1999. Gastrointestinal parasites of urban dogs in Perth, Western Australia. Veterinary Journal 57: 295–301.

    Google Scholar 

  • Dixon, B.R., Bussey, J., Parrington, L., Parenteau, Moore, R., Jacob, J., Parenteau, M.-P. and Fournier, J. 2002. A preliminary estimate of the prevalence of Giardia sp. in Beavers in Gatineau Park, Quebec, using flow cytometry. In: Olson, B.E., Olson, M.E., Wallis, P.M. (Eds.), Giardia: The cosmopolitan parasite. CAB International, Wallingford, UK, pp 71–79.

    Google Scholar 

  • Donham KJ. 2000. The concentration of swine production. Effects on swine health, productivity, human health, and the environment. Veterinary Clinics of North. America. Food Animal. Practice. 16: 559–597.

    CAS  Google Scholar 

  • Erlandsen, S.L. 1994. Biotic transmission — is giardiasis a zoonosis? in Giardia: from Molecules to Disease, (eds R.C.A. Thompson, J.A. Reynoldson and A.J. Lymbery), CAB International, Wallingford, pp. 83–97.

    Google Scholar 

  • Ey, P.L., Mansouri, M., Kulda, J. et al. 1997. Analysis of Giardia from hoofed animals reveals Articodactyl-specific and potentially zoonotic genotypes. Journal of Eukaryotic Microbiology 44: 626–635.

    CAS  PubMed  Google Scholar 

  • Filice, F.P. 1952. Studies on the cytology and life history of a Giardia from the laboratory rat. University of California Publications in Zoology 57: 53–146.

    Google Scholar 

  • Graczyk, T.K., Thompson, R.C.A., Fayer, R., Adams, P., Morgan, U.M and Lewis, E.J. 1999. Giardia duodenalis cysts of genotype A recovered from clams in the Chesapeake Bay subestuary, Rhode river. American Journal of Tropical Medicine and Hygiene 61: 526–529.

    CAS  PubMed  Google Scholar 

  • Graczyk, T.K., Bosco-Nizeyi, J., Ssebide, B., Thompson, R.C.A., Read, C. and Cranfield, M R. 2002. Anthropozoonotic Giardia duodenalis genotype (assemblage) A infections in habitats of free-ranging human-habituated gorillas, Uganda. Journal of Parasitology 88: 905–909.

    Article  PubMed  Google Scholar 

  • Heitman, T.L., Frederick, L.M., Viste, J.R., Guselle, N.J., Cooke, S.E., Roy, L., Morgan, U.M., Thompson, R.C.A. and Olson, M.E. 2002. Prevalence of Giardia and Cryptosporidium and characterisation of Cryptosporidium spp. isolated from wildlife, human and agricultural sources of the North Saskatchewan River basin in Alberta, Canada. Canadian Journal of Microbiology 48: 530–541.

    Article  CAS  PubMed  Google Scholar 

  • Hoar, B.R., Atwill, E.R., Elmi, C. and Farver, T.B. 2001. An examination of risk factors associated with beef cattle shedding pathogens of potential zoonotic concern. Epidemiology and Infection 127: 147–155.

    Article  CAS  PubMed  Google Scholar 

  • Hopkins, R.M., Meloni, B.P., Groth, D.M., Wetherall, J.D., Reynoldson, J.A. and Thompson, R.C.A. 1997. Ribosomal RNA sequencing reveals differences between the genotypes of Giardia isolates recovered from humans and dogs living in the same locality. Journal of Parasitology 83: 44–51.

    CAS  PubMed  Google Scholar 

  • Hopkins, R.M., Constantine, C.C., Groth, D.M., Reynoldson, J.A. and Thompson, R.C.A. 1999. DNA fingerprinting of Giardia duodenalis isolates using the intergenic rDNA spacer. Parasitology 118: 531–539.

    Article  CAS  PubMed  Google Scholar 

  • Hoque, M.E., Hope, V.T., Kjellstrom, T., Scragg, R., Lay-Yee, R., 2002. Risk of giardiasis in Aucklanders: a case-control study. International Journal of Infectious Diseases. 6: 191

    PubMed  Google Scholar 

  • Isaac-Renton, J.L., Cordeiro, C., Sarafis, K. et al. 1993. Characterization of Giardia duodenalis isolates from a waterborne outbreak. Journal of Infectious Diseases 167: 431–40.

    CAS  PubMed  Google Scholar 

  • Jakubowski, W. and Graun, G.F. 2002. Update on the control of Giardiain water supplies. In: Olson, B.E., Olson, M.E., Wallis, P.M. (Eds.), Giardia: The cosmopolitan parasite. CAB International, Wallingford, UK, pp 217–238.

    Google Scholar 

  • Levine, W.C., Stephenson, W.T. and Craun, G.F. 1990. Waterborne disease outbreaks, 1986–1988. Morbidity and Mortality Weekly Report 39:1–13.

    CAS  Google Scholar 

  • Marti, M., Li, Y., Schraner, E.M., Wild, P., Kohler, P. and Hehl, A.B. 2003a. The secretory apparatus of an ancient eukaryote: protein sorting to separate export pathways occurs before formation of transient golgi-like compartments. Molecular Biology of the Cell 14: 1433–1447.

    Article  CAS  PubMed  Google Scholar 

  • Marti, M., Regos, A., Li, Y., Schraner, E.M., Wild, P., Muller, N., Knopf, L.G. and Hehl, A.B. 2003b. An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis. Journal of Biological Chemistry 278: 24837–24848.

    Article  CAS  PubMed  Google Scholar 

  • Mayrhofer, G., Andrews, R.H., Ey, P.L. et al. 1995. Division of Giardia isolates from humans into two genetically distinct assemblages by electrophoretic analysis of enzymes encoded at 27 loci and comparison with Giardiamuris. Parasitology 111: 11–17.

    CAS  PubMed  Google Scholar 

  • McGlade, T.R., Robertson, I.D., Elliott, A.D. and Thompson, R.C.A. 2003. High prevalence of Giardia detected in cats by PCR. Veterinary Parasitology. 110: 197–205.

    Article  CAS  PubMed  Google Scholar 

  • Meyer, E.A. 1994. Giardia as an organism. In Giardia: from Molecules to Disease, (eds R.C.A. Thompson, J.A. Reynoldson and A.J. Lymbery), CAB International, Wallingford, pp. 3–15.

    Google Scholar 

  • Monis, P.T. and Thompson, R.C.A. 2003. Cryptosporidium and Giardia — zoonoses: fact or fiction? Infection, Genetics and evolution (in press).

    Google Scholar 

  • Monis, P.T., Mayrhofer, G., Andrews, R.H. et al. 1996. Molecular genetic analysis of Giardia intestinalis isolates at the glutamate dehydrogenase gene. Parasitology 112: 1–12.

    CAS  PubMed  Google Scholar 

  • Monis, P.T., Andrews, R.H., Mayhofer, G. et al. 1998. Novel lineages of Giardia intestinalis identified by genetic analysis of organisms isolated from dogs in Australia. Parasitology 116: 7–19.

    Article  CAS  PubMed  Google Scholar 

  • Monzingo, D.L. Jr. and Hibler, C.P., 1987. Prevalence of Giardia sp. in a beaver colony and the resulting environmental contamination. Journal of Wildlife Diseases. 23: 576–585.

    PubMed  Google Scholar 

  • O’Handley, R.M., 2002. Giardia in farm animals. In: Olson, B.E., Olson, M.E., Wallis, P.M. (Eds.), Giardia: The cosmopolitan parasite. CAB International, Wallingford, UK, pp 97–105.

    Google Scholar 

  • O’Handley R, Cockwill C, McAllister TA, et al. 1999. Duration of naturally acquired giardiasis and cryptosporidiosis in dairy calves and their association with diarrhoea. Journal of the Americam Veerinary Medical Association 214: 391–396.

    CAS  Google Scholar 

  • O’Handley RM, Olson ME, Fraser D, et al. 2000. Prevalence and genotypic characterisation of Giardia in dairy calves from Western Australia and Western Canada. Veterinary Parasitology 90: 193–200.

    CAS  PubMed  Google Scholar 

  • Olson, M.E., McAllister, T.A., Deselliers, L. et al. 1995. Effects of giardiasis on production in a domestic ruminant (lamb) model. American Journal of Veterinary Research 56: 1470–1474.

    CAS  PubMed  Google Scholar 

  • Pavlasak, I., Hess, L., Stehlik, I. et al. 1995. The first detection of Giardia spp. in horses in the Czech Republic. Veterinariya Meditsina (Praha), 40: 81–86.

    Google Scholar 

  • Ralston, B.J. McAllister T.A. and Olson M.E. 2003. Prevalence and infectionpattern of naturally acquired giardiasis and cryptosporidiosis in range beef calves and their dams. Veterinary Parasitology 114: 113–122.

    PubMed  Google Scholar 

  • Rickard, L.G., Siefker, C., Boyle, C.R., Gentz, E.J., 1999. The prevalence of Cryptosporidium and Giardia spp. in fecal samples from free-ranging white-tailed deer (Odocoileus virginianus) in the southeastern United States. Journal of Veterinary Diagnostic Investigation 11: 65–72.

    CAS  PubMed  Google Scholar 

  • Rodriguez-Hernandez J., Canut-Blasco A. and Martin-Sanchez A.M. 1996. Seasonal prevalence’s of Cryptosporidium and Giardia infections in children attending day care centres in Salamanca (Spain) studied for a period of 15 months. European Journal of Epidemiology 12: 291–295.

    CAS  PubMed  Google Scholar 

  • Simpson, A.G., Roger, A.J., Silberman, J.D., Leipe, D.D., Edgcomb, V.P., Jermiin, L.S., Patterson, D.J. and Sogin, M.L. 2002. Evolutionary history of “early-diverging” eukaryotes: the excavate taxon Carpediemonas is a close relative of Giardia. Molecular Biology and Evolution 19: 1782–91.

    CAS  PubMed  Google Scholar 

  • Thurman, R., Faulkner, B., Veal, D. et al. 1998. Water quality in rural Australia. Journal of Applied Microbiology 84: 627–632.

    Article  CAS  PubMed  Google Scholar 

  • Thompson, R.C.A. 1998. Giardia infections. In: Zoonoses: Biology, Clinical Practice and Public Health Control. (eds S.R. Palmer, E.J.L. Soulsby, and D.I.H. Simpson), Oxford University Press, Oxford, pp. 545–561.

    Google Scholar 

  • Thompson, R.C.A. 2000. Giardiasis as a re-emerging infectious disease and its zoonotic potential. International Journal for Parasitology 30: 1259–1267.

    CAS  PubMed  Google Scholar 

  • Thompson, R.C.A., 2002. Towards a better understanding of host specificity and the transmission of Giardia: The impact of molecular epidemiology. In: Giardia: Olson, B.E., Olson, M.E., Wallis, P.M. (Eds.), The cosmopolitan parasite. CAB International, Wallingford, UK, pp 55–69.

    Google Scholar 

  • Thompson, R.C.A. 2003a. Molecular epidemiology of Giardia and Cryptosporidium infections. Journal of Parasitology, 89: S134–S140.

    Google Scholar 

  • Thompson, R.C.A. 2003b The Zoonotic Significance and Molecular Epidemiology of Giardia and Giardiasis Veterinary Parasitology (in press).

    Google Scholar 

  • Thompson, R.C.A, and Boreham, P.F.L. 1994. Biotic and abiotic transmission, In: Giardia: from molecules to disease, (eds R.C.A. Thompson, J.A. Reynoldson and A.J. Lymbery), CAB International, Wallingford, pp. 131–136.

    Google Scholar 

  • Thompson, R.C.A., Lymbery, A.J. and Meloni, B.P. 1990. Genetic variation in Giardia Kunstler, 1882: taxonomic and epidemiological significance. Protozoological Abstracts 14: 1–28.

    Google Scholar 

  • Thompson, R.C.A., Reynoldson, J.A. and Mendis, A.H.W. 1993. Giardia and giardiasis. Advances in Parasitology 32: 71–160.

    CAS  PubMed  Google Scholar 

  • Thompson, R.C.A., Hopkins, R.M. and Homan, W.L. 1999. Nomenclature and genetic groupings of Giardia infecting mammals. Parasitology Today 16: 210–213.

    Google Scholar 

  • Thurston-Enriquez, J.A., Watt, P., Dowd, S.E., Enriquez, R., Pepper, I.L. and Gerba, C.P. 2002. Detection of protozoan parasites and microsporidia in irrigation waters used for crop production. Journal of Food Protection 65: 378–382.

    PubMed  Google Scholar 

  • Traub, R.J., Robertson, I.D., Irwin, P., Mencke, N. and Thompson, R.C.A., 2002. The role of dogs in transmission of gastrointestinal parasites in a remote tea-growing community in northeast India. American Journal of Tropical Medicine and Hygiene 67: 539–45.

    PubMed  Google Scholar 

  • Traub, R.J., Monis, P., Robertson, I., Irwin, P., Mencke, N. and Thompson, R.C.A. 2003. Epidemiological and molecular evidence supports the zoonotic transmission of Giardia among humans and dogs living in the same community. Parasitology (in press).

    Google Scholar 

  • Van Keulen, H., Feely, D.E., and Macechko, P.T. et al. 1998. The sequence of Giardia small subunit rRNA shows that voles and muskrats are parasitized by a uniquespecies Giardia microti. Journal or Parasitology 84: 294–300.

    PubMed  Google Scholar 

  • WHO, 1979. Parasitic Zoonoses. Report of a WHO Expert Committee with the participation of FAO. Technical Report Series No. 637. World Health Organization, Geneva.

    Google Scholar 

  • WHO, 1996. The World Health Report 1996. Fighting Disease Fostering Development. World Health Organization, Geneva.

    Google Scholar 

  • Xiao L. 1994. Giardia infection in farm animals. Parasitology Today 10: 436–438.

    Article  CAS  PubMed  Google Scholar 

  • Xiao, L. and Herd, R.P. 1994. Infection pattern of Cryptosporidium and Giardia in calves. Veterinary Parasitology 55: 257–262.

    Article  CAS  PubMed  Google Scholar 

  • Xiao, L., Herd, R.P. and McClure, K.E. 1994. Periparturient rise in the excretion of Giardia sp. cysts and Cryptosporidium parvum oocysts as a source of infection for lambs. Journal of Parasitology 80: 55–59.

    CAS  PubMed  Google Scholar 

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  1. WHO Collaborating Centre For The Molecular Epidemiology Of Parasitic Infections and Western Australian Biomedical Research Institute, Division Of Veterinary And Biomedical Sciences, Murdoch University, Murdoch, Western Australia, 6150

    R C Andrew Thompson

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  1. University of Arizona, Tucson, Arizona

    Charles R. Sterling  & Rodney D. Adam  & 

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© 2004 Kluwer Academic Publishers

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Thompson, R.C.A. (2004). Epidemiology and Zoonotic Potential of Giardia Infections. In: Sterling, C.R., Adam, R.D. (eds) The Pathogenic Enteric Protozoa: Giardia, Entamoeba, Cryptosporidium and Cyclospora. World Class Parasites, vol 8. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7878-1_1

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  • DOI: https://doi.org/10.1007/1-4020-7878-1_1

  • Publisher Name: Springer, Boston, MA

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